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Recombinant Human KGF/FGF-7 Protein

Catalog #: 251-KG
85 Citations 1 Review Datasheet
GMP Version Available: 251-GMP
GMP

Carrier Free

Catalog # Availability Size / Price Qty
251-KG-010/CF
251-KG-050/CF
251-KG-01M/CF

With Carrier

Catalog # Availability Size / Price Qty
251-KG-010
251-KG-050
251-KG-01M
Recombinant Human KGF/FGF-7 Protein Bioactivity
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Product Details
Citations (85)
FAQs
Reviews (1)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human KGF/FGF-7 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using 4MBr‑5 rhesus monkey epithelial cells. Rubin, J.S. et al. (1989) Proc. Natl. Acad. Sci. USA 86:802. The ED50 for this effect is typically 6-60 ng/mL.
Source
E. coli-derived human KGF/FGF-7 protein
Cys32-Thr194, with an N-terminal Met
Accession #
P21781
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
19 kDa

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251-KG (with carrier)

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251-KG/CF (carrier free)

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

251-KG

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and EDTA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

251-KG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in MOPS, Na2SO4 and EDTA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human KGF/FGF-7 Protein Bioactivity View Larger

Recombinant Human KGF/FGF-7 (Catalog # 251-KG) stimulates cell proliferation of 4MBr-5 rhesus monkey epithelial cells. The ED50 for this effect is 6-60 ng/mL.

Bioactivity View Larger

Adult stem cells isolated from human lung biopsy tissue were embedded in Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and cultured for 20-60 days in lung organoid expansion medium, which includes Recombinant Human KGF/FGF-7 (Catalog # 251-KG), Recombinant Human FGF-10 (345-FG), Recombinant Human Noggin (6057-NG), and Recombinant Human R-Spondin 1 (4645-RS), along with the other reagents listed in the lung organoid expansion medium recipe in the lung organoid culture protocol. Lung organoids were able to differentiate and exhibit markers for various cell types of the lung. Lung organoids were stained with (A) a Rabbit Anti-Human Cytokeratin 5 (KRT5) Monoclonal Antibody (Novus Biologicals, Catalog # NB110-56916; green) and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, (B) a Hamster Anti-Mouse Podoplanin (PDPN) Monoclonal Antibody (Novus Biologicals, Catalog # NB600-1015; green) to visualize alveolar type I cells and a Goat Anti-Human p63/TP73L Polyclonal Antibody (AF1916; red) to visualize basal cells, and (C, D) a Mouse Anti-MUC5AC Monoclonal Antibody (Novus Biologicals, Catalog # NBP2-15196; green) to visualize Goblet cells and a Mouse Anti-Human/Mouse/Rat SOX2 Monoclonal Antibody (MAB2018; red). All samples were counterstained with DAPI (5748; blue).

Background: KGF/FGF-7

KGF (keratinocyte growth factor), also known as FGF-7 (fibroblast growth factor-7), is one of 22 known members of the mouse FGF family of secreted proteins that plays a key role in development, morphogenesis, angiogenesis, wound healing, and tumorigenesis (1-4). KGF expression is restricted to cells of mesenchymal origin. When secreted, it acts as a paracrine growth factor for nearby epithelial cells (1). KGF speeds wound healing by being dramatically upregulated in response to damage to skin or internal structures that results in high local concentrations of inflammatory mediators such as IL-1 and TNF-alpha. (2, 5). KGF promotes cell migration and invasion, and mediates melanocyte transfer to keratinocytes upon UVB radiation (6, 7). It has been used ectopically to avoid chemotherapy-induced oral mucositis in patients with hematological malignancies (1). Deletion of KGF affects kidney development, producing abnormally small ureteric buds and fewer nephrons (8). It also impedes hair follicle differentiation (9). The 194 amino acid (aa) KGF precursor contains a 31 aa signal sequence and, like all other FGFs, an ~120 aa beta -trefoil scaffold that includes receptor- and heparin-binding sites. KGF signals only through the IIIb splice form of the tyrosine kinase receptor, FGF R2 (FGF R2-IIIb/KGF R) (10). Receptor dimerization requires an octameric or larger heparin or heparin sulfate proteoglycan (11). FGF-10, also called KGF2, shares 51% aa identity and similar function to KGF, but shows more limited expression than KGF and uses an additional receptor, FGF R2-IIIc (12). Following receptor engagement, KGF is typically degraded, while FGF-10 is recycled (12). Mature human KGF, which is active across species, shares 98% aa sequence identity with bovine, equine, ovine and canine, 96% with mouse and porcine, and 92% with rat KGF, respectively.

References
  1. Finch, P.W. and J.S. Rubin (2006) J. Natl. Cancer Inst. 98:812.
  2. Werner, S. et al. (2007) J. Invest. Dermatol. 127:998.
  3. Werner, S. (1998) Cytokine Growth Factor Rev. 9:153.
  4. Mason, I.J. et al. (1994) Mech. Dev. 45:15.
  5. Geer, D.J. et al. (2005) Am. J. Pathol. 167:1575.
  6. Niu, J. et al. (2007) J. Biol. Chem. 282:6001.
  7. Cardinali, G. et al. (2005) J. Invest. Dermatol. 125:1190.
  8. Qiao, J. et al. (1999) Development 126:547.
  9. Guo, L. et al. (1996) Genes Dev. 10:165.
  10. de Georgi, V. et al. (2007) Dermatol. Clin. 25:477.
  11. Hsu, Y-R. et al. (1999) Biochemistry 38:2523.
  12. Belleudi, F. et al. (2007) Traffic 8:1854.
Long Name
Keratinocyte Growth Factor
Entrez Gene IDs
2252 (Human); 403915 (Canine)
Alternate Names
FGF7; FGF-7; fibroblast growth factor 7HBGF-7; HBGF7; HBGF-7; Heparin-binding growth factor 7; keratinocyte growth factor; KGF; KGFfibroblast growth factor 7 (keratinocyte growth factor)

Citations for Recombinant Human KGF/FGF-7 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

85 Citations: Showing 1 - 10
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  1. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
    Authors: Cheng, YC;Acedera, JD;Li, YJ;Shieh, SY;
    Cell death and differentiation
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A fibroblast-dependent TGF?1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis
    Authors: Cohen, ML;Brumwell, AN;Ho, TC;Montas, G;Golden, JA;Jones, KD;Wolters, PJ;Wei, Y;Chapman, HA;Le Saux, CJ;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
    Authors: Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW;
    Nature protocols
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  4. Opposing roles for TGF?- and BMP-signaling during nascent alveolar differentiation in the developing human lung
    Authors: Frum, T;Hsu, PP;Hein, RFC;Conchola, AS;Zhang, CJ;Utter, OR;Anand, A;Zhang, Y;Clark, SG;Glass, I;Sexton, JZ;Spence, JR;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  5. Generation and expansion of transitional lung organoids from human pluripotent stem cells
    Authors: IM Leko, N Schrode, J Torres, M Pezet, TA Thimraj, KG Beaumont, HW Snoeck
    bioRxiv : the preprint server for biology, 2023-02-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
    Authors: P Madrigal, S Deng, Y Feng, S Militi, KJ Goh, R Nibhani, R Grandy, A Osnato, D Ortmann, S Brown, S Pauklin
    Nature Communications, 2023-01-25;14(1):405.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. iPSCs derived from esophageal atresia patients reveal SOX2 dysregulation at the anterior foregut stage
    Authors: S Raad, A David, M Sagniez, B Paré, Z Orfi, NA Dumont, MA Smith, C Faure
    Disease Models & Mechanisms, 2022-11-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Organoids capture tissue-specific innate lymphoid cell development in mice and humans
    Authors: GM Jowett, E Read, LB Roberts, D Coman, M Vilà Gonzá, T Zabinski, U Niazi, R Reis, TJ Trieu, D Danovi, E Gentleman, L Vallier, MA Curtis, GM Lord, JF Neves
    Cell Reports, 2022-08-30;40(9):111281.
    Species: Mouse
    Sample Types: Organoid
    Applications: Bioassay
  9. Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling
    Authors: V Lungova, K Wendt, SL Thibeault
    Oncogene, 2022-08-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Human Pluripotent Stem Cell-Derived Alveolar Organoid with Macrophages
    Authors: HR Seo, HJ Han, Y Lee, YW Noh, SJ Cho, JH Kim
    International Journal of Molecular Sciences, 2022-08-16;23(16):.
    Species: Human
    Sample Types: Organoids
    Applications: Cell Culture
  11. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells
    Authors: RB Werder, T Liu, KM Abo, J Lindstrom-, C Villacorta, J Huang, A Hinds, N Boyer, E Bullitt, M Liesa, EK Silverman, DN Kotton, MH Cho, X Zhou, AA Wilson
    Oncogene, 2022-07-13;8(28):eabo6566.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Generation of Isogenic hiPSCs with Targeted Edits at Multiple Intronic SNPs to Study the Effects of the Type 2 Diabetes Associated KCNQ1 Locus in American Indians
    Authors: AK Nair, M Traurig, JR Sutherland, YL Muller, ED Grellinger, L Saporito, RG Nelson, C Bogardus, LJ Baier
    Cells, 2022-04-25;11(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Microwell bag culture for large-scale production of homogeneous islet-like clusters
    Authors: R Suenaga, S Konagaya, J Yamaura, R Ito, S Tanaka, Y Ishizaki, T Toyoda
    Scientific Reports, 2022-03-25;12(1):5221.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. An HNF1alpha truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1beta function
    Authors: AM Cujba, ME Alvarez-Fa, S Pedraza-Ar, A Laddach, MH Shepherd, AT Hattersley, FM Watt, R Sancho
    Cell Reports, 2022-03-01;38(9):110425.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
    Authors: K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang
    Cell Transplantation, 2022-01-01;31(0):9636897211066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
    Authors: JJ Kathiriya, C Wang, M Zhou, A Brumwell, M Cassandras, CJ Le Saux, M Cohen, KD Alysandrat, B Wang, P Wolters, M Matthay, DN Kotton, HA Chapman, T Peng
    Nature Cell Biology, 2021-12-30;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  17. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
    Authors: RJ Geusz, A Wang, DK Lam, NK Vinckier, KD Alysandrat, DA Roberts, J Wang, S Kefalopoul, A Ramirez, Y Qiu, J Chiou, KJ Gaulton, B Ren, DN Kotton, M Sander
    Nature Communications, 2021-11-17;12(1):6636.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue
    Authors: DA Newton, RG Lottes, RM Ryan, DD Spyropoulo, JE Baatz
    Respiratory Research, 2021-10-28;22(1):278.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  19. Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection
    Authors: AV Parent, G Faleo, J Chavez, M Saxton, DI Berrios, NR Kerper, Q Tang, M Hebrok
    Cell Reports, 2021-08-17;36(7):109538.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
    Authors: MO Lee, SG Lee, CR Jung, YS Son, JW Ryu, KB Jung, JH Ahn, JH Oh, HA Lee, JH Lim, J Kim, I Jang, J Choi, J Jung, K Park, B Lee, DS Kim, MY Son, HS Cho
    Nature Communications, 2021-07-23;12(1):4492.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation
    Authors: AC Harttrampf, MEM da Costa, A Renoult, E Daudigeos-, B Geoerger
    BMC Cancer, 2021-07-20;21(1):833.
    Species: Human
    Sample Types: Whole Cells
    Applications: Stimulation
  22. The in vitro multilineage differentiation and maturation of lung and airway cells from human pluripotent stem cell-derived lung progenitors in 3D
    Authors: AL Rodrigues, HY Liu, YW Chen, M Porotto, A Moscona, HW Snoeck
    Nature Protocols, 2021-03-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors
    Authors: Q Yan, Y Zhang, X Fang, B Liu, TL Wong, L Gong, S Liu, D Yu, M Liu, L Jiang, X Wang, T Wei, Y Jia, L Li, L Sun, Y Tang, N Zhou, YF Yuan, Y Li, S Ma, XY Guan
    Cell Death and Differentiation, 2021-01-26;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. CXCR4 Regulates Temporal Differentiation via PRC1 Complex in Organogenesis of Epithelial Glands
    Authors: J Kim, SW Lee, K Park
    International Journal of Molecular Sciences, 2021-01-10;22(2):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Heat-Not-Burn cigarette induces oxidative stress response in primary rat alveolar epithelial cells
    Authors: Y Ito, K Oshinden, N Kutsuzawa, C Kohno, S Isaki, K Yokoyama, T Sato, M Tanaka, K Asano
    PLoS ONE, 2020-11-25;15(11):e0242789.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  26. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    Cell Stem Cell, 2020-09-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
    Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
    Res Sq, 2020-09-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells
    Authors: AFM Dost, AL Moye, M Vedaie, LM Tran, E Fung, D Heinze, C Villacorta, J Huang, R Hekman, JH Kwan, BC Blum, SM Louie, SP Rowbotham, J Sainz de A, ME Piper, PJ Bhetariya, RT Bronson, A Emili, G Mostoslavs, GA Fishbein, WD Wallace, K Krysan, SM Dubinett, J Yanagawa, DN Kotton, CF Kim
    Cell Stem Cell, 2020-09-04;27(4):663-678.e8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    bioRxiv, 2020-08-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Antagonism of interferon signaling by fibroblast growth factors promotes viral replication
    Authors: L Maddaluno, C Urwyler, T Rauschendo, M Meyer, D Stefanova, R Spörri, M Wietecha, L Ferrarese, D Stoycheva, D Bender, N Li, G Strittmatt, K Nasirujjam, HD Beer, P Staeheli, E Hildt, A Oxenius, S Werner
    EMBO Mol Med, 2020-07-27;0(0):e11793.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1/2-Mediated Degradation of Estrogen Receptor Alpha
    Authors: KA Ludwik, ZM Sandusky, KM Stauffer, Y Li, KL Boyd, GA O'Doherty, TP Stricker, DA Lannigan
    Cell Rep, 2020-07-21;32(3):107931.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
    Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
    Nat Commun, 2020-04-29;11(1):2082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets
    Authors: M Liu, Q Yan, Y Sun, Y Nam, L Hu, JH Loong, Q Ouyang, Y Zhang, HL Li, FE Kong, L Li, Y Li, MM Li, W Cheng, LX Jiang, S Fang, XD Yang, JQ Mo, YF Gong, YQ Tang, Y Li, YF Yuan, NF Ma, G Lin, S Ma, JG Wang, XY Guan
    Proc. Natl. Acad. Sci. U.S.A., 2020-03-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  35. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020;27(1):125-136.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Derivation of self-renewing lung alveolar epithelial type II cells from human pluripotent stem cells
    Authors: A Jacob, M Vedaie, DA Roberts, DC Thomas, C Villacorta, KD Alysandrat, F Hawkins, DN Kotton
    Nat Protoc, 2019-11-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells
    Authors: LS Beier, J Rossa, S Woodhouse, S Bergmann, HB Kramer, J Protze, M Eichner, A Piontek, S Vidal-Y-Sy, JM Brandner, G Krause, N Zitzmann, J Piontek
    Int J Mol Sci, 2019-09-26;20(19):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
    Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
    Nat Commun, 2019-09-24;10(1):4161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF- β2 suppression
    Authors: S Fujimoto, R Hayashi, S Hara, Y Sasamoto, J Harrington, M Tsujikawa, K Nishida
    Regen Ther, 2019-09-12;11(0):249-257.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
    Authors: K Lee, H Cho, RW Rickert, QV Li, J Pulecio, CS Leslie, D Huangfu
    Cell Rep, 2019-07-09;28(2):382-393.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Point mutations in the PDX1 transactivation domain impair human ?-cell development and function
    Authors: X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2019-03-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
  42. Generation of lung organoids from human pluripotent stem cells in vitro
    Authors: AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence
    Nat Protoc, 2019-02-01;14(2):518-540.
    Species: Human
    Sample Types: Spheroids
    Applications: Bioassay
  43. An integrated chromatin accessibility and transcriptome landscape of human pre-implantation embryos
    Authors: L Liu, L Leng, C Liu, C Lu, Y Yuan, L Wu, F Gong, S Zhang, X Wei, M Wang, L Zhao, L Hu, J Wang, H Yang, S Zhu, F Chen, G Lu, Z Shang, G Lin
    Nat Commun, 2019-01-21;10(1):364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018-12-26;25(13):3811-3827.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
    Authors: Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
    Cell Stem Cell, 2018-09-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation
    Authors: JP Ng-Blichfe, A Schrik, RK Kortekaas, JA Noordhoek, IH Heijink, PS Hiemstra, J Stolk, M Königshoff, R Gosens
    EBioMedicine, 2018-09-17;36(0):461-474.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  47. Voltage-dependent Ca2+ channels promote branching morphogenesis of salivary glands by patterning differential growth
    Authors: JM Kim, S Choi, SW Lee, K Park
    Sci Rep, 2018-05-15;8(1):7566.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  48. IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells
    Authors: Y Ito, R Al Mubarak, N Roberts, K Correll, W Janssen, J Finigan, R Mishra, HW Chu
    PLoS ONE, 2018-04-19;13(4):e0196256.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Beta-Catenin maintains lung epithelial progenitors after lung specification
    Authors: EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen
    Development, 2018-03-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Authors: X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2018-01-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Generation of a human embryonic stem cell line expressing tetrameric Zoanthus sp. green fluorescent protein: NERCe002-A-1
    Authors: X Duan, M Xie, Y Peng, L Hu, J Yu, S Zeng, Y Wang, G Lu, G Lin, Y Sun
    Stem Cell Res, 2018-01-31;28(0):6-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Functional vascularized lung grafts for lung bioengineering
    Authors: NV Dorrello, BA Guenthart, JD O'Neill, J Kim, K Cunningham, YW Chen, M Biscotti, T Swayne, HM Wobma, SXL Huang, HW Snoeck, M Bacchetta, G Vunjak-Nov
    Sci Adv, 2017-08-30;3(8):e1700521.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Small molecule AT7867 proliferates PDX1-expressing pancreatic progenitor cells derived from human pluripotent stem cells
    Authors: A Kimura, T Toyoda, Y Nishi, M Nasu, A Ohta, K Osafune
    Stem Cell Res, 2017-08-17;24(0):61-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. High-resolution promoter map of human limbal epithelial cells cultured with keratinocyte growth factor and rho kinase inhibitor
    Authors: M Yoshihara, Y Sasamoto, R Hayashi, Y Ishikawa, M Tsujikawa, Y Hayashizak, M Itoh, H Kawaji, K Nishida
    Sci Rep, 2017-06-06;7(1):2845.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Ex vivo analysis of the contribution of FGF10(+) cells to airway smooth muscle cell formation during early lung development
    Authors: E El Agha, V Kheirollah, A Moiseenko, W Seeger, S Bellusci
    Dev. Dyn., 2017-06-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors
    Authors: NAJ Krentz, D van Hoof, Z Li, A Watanabe, M Tang, C Nian, MS German, FC Lynn
    Dev. Cell, 2017-04-24;41(2):129-142.e6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017-03-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction
    Authors: JS Choi, HS Shin, HY An, YM Kim, JY Lim
    Oncotarget, 2017-02-21;8(8):13496-13508.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells
    Stem Cell Res Ther, 2016-11-16;7(1):165.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and Differentiation
    Authors: J Malaisse, V Pendaries, F Hontoir, V De Glas, D Van Vlaend, M Simon, C Lambert de, Y Poumay, B Flamion
    J. Biol. Chem, 2015-12-01;291(12):6347-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Unliganded fibroblast growth factor receptor 1 forms density-independent dimers.
    Authors: Comps-Agrar L, Dunshee D, Eaton D, Sonoda J
    J Biol Chem, 2015-08-13;290(40):24166-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. DNA methylation directs functional maturation of pancreatic beta cells.
    Authors: Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A
    J Clin Invest, 2015-06-22;125(7):2851-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
    Authors: Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor A, Yasuda Y, Niki T
    BMC Cancer, 2015-02-25;15(0):82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells.
    Authors: Wong, Amy P, Chin, Stephani, Xia, Sunny, Garner, Jodi, Bear, Christin, Rossant, Janet
    Nat Protoc, 2015-02-05;10(3):363-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015-02-05;10(3):413-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Human marrow stromal cells downsize the stem cell fraction of lung cancers by fibroblast growth factor 10.
    Authors: Kanehira M, Kikuchi T, Santoso A, Tode N, Hirano T, Ohkouchi S, Tamada T, Sugiura H, Harigae H, Ichinose M
    Mol Cell Biol, 2014-05-27;34(15):2848-56.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2013-12-19;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells.
    Authors: Huang, Sarah X, Islam, Mohammad, O'Neill, John, Hu, Zheng, Yang, Yong-Gua, Chen, Ya-Wen, Mumau, Melanie, Green, Michael, Vunjak-Novakovic, Gordana, Bhattacharya, Jahar, Snoeck, Hans-Wil
    Nat Biotechnol, 2013-12-01;32(1):84-91.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  70. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
    Authors: Herbert C, Schieborr U, Saxena K, Juraszek J, De Smet F, Alcouffe C, Bianciotto M, Saladino G, Sibrac D, Kudlinzki D, Sreeramulu S, Brown A, Rigon P, Herault J, Lassalle G, Blundell T, Rousseau F, Gils A, Schymkowitz J, Tompa P, Herbert J, Carmeliet P, Gervasio F, Schwalbe H, Bono F
    Cancer Cell, 2013-04-15;23(4):489-501.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. A stimulation-dependent alternate core promoter links lymphotoxin alpha expression with TGF-beta1 and fibroblast growth factor-7 signaling in primary human T cells.
    Authors: Yokley B, Selby S, Posch P
    J Immunol, 2013-04-01;190(9):4573-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2012-11-16;20(3):369-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Generation of glucose-responsive, insulin-producing cells from human umbilical cord blood-derived mesenchymal stem cells.
    Authors: Prabakar K, Dominguez-Bendala J, Molano R, Pileggi A, Villate S, Ricordi C, Inverardi L
    Cell Transplant, 2011-12-21;21(6):1321-39.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  74. Altered splicing of FGFR1 is associated with high tumor grade and stage and leads to increased sensitivity to FGF1 in bladder cancer.
    Authors: Tomlinson DC, Knowles MA
    Am. J. Pathol., 2010-10-01;177(5):2379-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression.
    Authors: Yamamoto S, Fukumoto E, Yoshizaki K, Iwamoto T, Yamada A, Tanaka K, Suzuki H, Aizawa S, Arakaki M, Yuasa K, Oka K, Chai Y, Nonaka K, Fukumoto S
    J. Biol. Chem., 2008-06-17;283(34):23139-49.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  76. Specific heparan sulfate structures modulate FGF10-mediated submandibular gland epithelial morphogenesis and differentiation.
    Authors: Patel VN, Likar KM, Zisman-Rozen S, Cowherd SN, Lassiter KS, Sher I, Yates EA, Turnbull JE, Ron D, Hoffman MP
    J. Biol. Chem., 2008-01-28;283(14):9308-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Heparanase cleavage of perlecan heparan sulfate modulates FGF10 activity during ex vivo submandibular gland branching morphogenesis.
    Authors: Patel VN, Knox SM, Likar KM, Lathrop CA, Hossain R, Eftekhari S, Whitelock JM, Elkin M, Vlodavsky I, Hoffman MP
    Development, 2007-10-24;134(23):4177-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis.
    Authors: Sa SM, Valdez PA, Wu J
    J. Immunol., 2007-02-15;178(4):2229-40.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Differentiated human alveolar epithelial cells and reversibility of their phenotype in vitro.
    Authors: Wang J, Edeen K, Manzer R, Chang Y, Wang S, Chen X, Funk CJ, Cosgrove GP, Fang X, Mason RJ
    Am. J. Respir. Cell Mol. Biol., 2007-01-25;36(6):661-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
    Authors: Li F, Shetty AK, Sugahara K
    J. Biol. Chem., 2006-12-04;282(5):2956-66.
    Species: Fish - Prionace glauca (Blue Shark)
    Sample Types: Peptide
    Applications: Bioassay
  81. FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc.
    Authors: Nakayama T, Mutsuga N, Tosato G
    Blood, 2006-10-31;109(4):1363-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Development of an in vitro pancreatic tissue model to study regulation of islet neogenesis associated protein expression.
    Authors: Petropavlovskaia M, Makhlin J, Sampalis J, Rosenberg L
    J. Endocrinol., 2006-10-01;191(1):65-81.
    Species: Hamster
    Sample Types: Whole Cells
    Applications: Bioassay
  83. The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.
    Authors: Beer HD, Bittner M, Niklaus G, Munding C, Max N, Goppelt A, Werner S
    Oncogene, 2005-08-11;24(34):5269-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Keratinocyte-fibroblast paracrine interaction: the effects of substrate and culture condition.
    Authors: Witte RP, Kao WJ
    Biomaterials, 2005-06-01;26(17):3673-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. FGFR2b signaling regulates ex vivo submandibular gland epithelial cell proliferation and branching morphogenesis.
    Authors: Steinberg Z, Myers C, Heim VM, Lathrop CA, Rebustini IT, Stewart JS, Larsen M, Hoffman MP
    Development, 2005-02-16;132(6):1223-34.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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Recombinant Human KGF/FGF-7 Protein
By Ermali Aliaj on 01/02/2021
Application: Cell Culture