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Recombinant Human CNTF Protein

Catalog #: 257-NT
63 Citations Datasheet

Carrier Free

Catalog # Availability Size / Price Qty
257-NT-010/CF
257-NT-050/CF

With Carrier

Catalog # Availability Size / Price Qty
257-NT-010
257-NT-050
Recombinant Human CNTF Protein Bioactivity
2 Images
Product Details
Citations (63)
FAQs
Supplemental Products
Reviews
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human CNTF Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.03-0.18 μg/mL.
The proliferative effect can be enhanced up to 100-fold by the addition of Recombinant Human CNTF R alpha (Catalog # 303-CR) .
Source
E. coli-derived human CNTF protein
Ala2-Met200
Accession #
P26441.1
N-terminal Sequence
Analysis
Ala2
Structure / Form

This recombinant protein is prone to proteolytic degradation at the C-terminus, resulting in proteins with molecular masses of 22.2-22.8 kDa.

Predicted Molecular Mass
22.8 kDa
SDS-PAGE
23-26 kDa, reducing conditions

Product Datasheets

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257-NT (with carrier)

Product Datasheet

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257-NT/CF (carrier free)

Product Datasheet

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

257-NT

Formulation Lyophilized from a 0.2 μm filtered solution in Tris, NaCl, TCEP, EDTA, CHAPS and Trehalose with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after reconstitution.

257-NT/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Tris, NaCl, TCEP, EDTA, CHAPS and Trehalose.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, 2 to 8 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Human CNTF Protein Bioactivity View Larger

Recombinant Human CNTF (Catalog # 257‑NT) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED50 for this effect is 0.03-0.18 μg/mL.

SDS-PAGE Recombinant Human CNTF Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human CNTF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a band at 26 kDa.

Background: CNTF

Ciliary neurotrophic factor (CNTF) is a polypeptide initially purified from chick embryo ocular tissue and identified as a trophic factor for embryonic chick ciliary parasympathetic neurons in culture. Subsequent studies have demonstrated that CNTF is a survival factor for additional neuronal cell types including: dorsal root ganglion sensory neurons, sympathetic ganglion neurons, embryonic motor neurons, major pelvic ganglion neurons and hippocampal neurons. CNTF has also been shown to prevent the degeneration of motor axons after axotomy.

The gene for human CNTF has been localized to the proximal region of the long arm of chromosome 11. The cDNA for human CNTF encodes a 200 amino acid residue polypeptide that lacks a signal sequence. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL-6, IL-11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal-transducing subunit in their receptor complexes.

Long Name
Ciliary Neurotrophic Factor
Entrez Gene IDs
1270 (Human); 12803 (Mouse); 25707 (Rat)
Alternate Names
ciliary neurotrophic factor; CNTF; HCNTF

Citations for Recombinant Human CNTF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

63 Citations: Showing 1 - 10
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  1. Biallelic variants in CSMD1 are implicated in a neurodevelopmental disorder with intellectual disability and variable cortical malformations
    Authors: Werren, EA;Peirent, ER;Jantti, H;Guxholli, A;Srivastava, KR;Orenstein, N;Narayanan, V;Wiszniewski, W;Dawidziuk, M;Gawlinski, P;Umair, M;Khan, A;Khan, SN;Geneviève, D;Lehalle, D;van Gassen, KLI;Giltay, JC;Oegema, R;van Jaarsveld, RH;Rafiullah, R;Rappold, GA;Rabin, R;Pappas, JG;Wheeler, MM;Bamshad, MJ;Tsan, YC;Johnson, MB;Keegan, CE;Srivastava, A;Bielas, SL;
    Cell death & disease
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Engineered Interleukin-6-derived cytokines recruit artificial receptor complexes and disclose CNTF signaling via the OSMR
    Authors: Rafii, P;Cruz, PR;Ettich, J;Seibel, C;Padrini, G;Wittich, C;Lang, A;Petzsch, P;Köhrer, K;Moll, JM;Floss, DM;Scheller, J;
    The Journal of biological chemistry
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived C9orf72 -associated ALS/FTD motor neurons
    Authors: Martin, EJ;Santacruz, C;Mitevska, A;Jones, IE;Krishnan, G;Gao, FB;Finan, JD;Kiskinis, E;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Cell-free fat extract promotes axon regeneration and retinal ganglion cells survival in traumatic optic neuropathy
    Authors: Sun, Y;Chen, D;Dai, T;Yu, Z;Xie, H;Wang, X;Zhang, W;
    Frontiers in cellular neuroscience
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo assay
  5. Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteins
    Authors: Alves, J;Schwinn, M;Machleidt, T;Goueli, SA;Cali, JJ;Zegzouti, H;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Human spinal interneurons repair the injured spinal cord through synaptic integration
    Authors: Zholudeva, LV;Fortino, T;Agrawal, A;Vila, OF;Williams, M;McDevitt, T;Lane, MA;Srivastava, D;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs
    Authors: Krug, B;Hu, B;Chen, H;Ptack, A;Chen, X;Gretarsson, KH;Deshmukh, S;Kabir, N;Andrade, AF;Jabbour, E;Harutyunyan, AS;Lee, JJY;Hulswit, M;Faury, D;Russo, C;Xu, X;Johnston, MJ;Baguette, A;Dahl, NA;Weil, AG;Ellezam, B;Dali, R;Blanchette, M;Wilson, K;Garcia, BA;Soni, RK;Gallo, M;Taylor, MD;Kleinman, CL;Majewski, J;Jabado, N;Lu, C;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS/FTD poly-GR pathophysiology
    Authors: Ortega, JA;Sasselli, IR;Boccitto, M;Fleming, AC;Fortuna, TR;Li, Y;Sato, K;Clemons, TD;Mckenna, ED;Nguyen, TP;Anderson, EN;Asin, J;Ichida, JK;Pandey, UB;Wolin, SL;Stupp, SI;Kiskinis, E;
    Science advances
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. CRISPR/Cas9 Directed Reprogramming of iPSC for Accelerated Motor Neuron Differentiation Leads to Dysregulation of Neuronal Fate Patterning and Function
    Authors: Davis-Anderson, K;Micheva-Viteva, S;Solomon, E;Hovde, B;Cirigliano, E;Harris, J;Twary, S;Iyer, R;
    International journal of molecular sciences
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis
    Authors: Tsioras, K;Smith, KC;Edassery, SL;Garjani, M;Li, Y;Williams, C;McKenna, ED;Guo, W;Wilen, AP;Hark, TJ;Marklund, SL;Ostrow, LW;Gilthorpe, JD;Ichida, JK;Kalb, RG;Savas, JN;Kiskinis, E;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells
    Authors: Jovanovic, VM;Weber, C;Slamecka, J;Ryu, S;Chu, PH;Sen, C;Inman, J;De Sousa, JF;Barnaeva, E;Hirst, M;Galbraith, D;Ormanoglu, P;Jethmalani, Y;Mercado, JC;Michael, S;Ward, ME;Simeonov, A;Voss, TC;Tristan, CA;Singeç, I;
    Stem cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. High-content synaptic phenotyping in human cellular models reveals a role for BET proteins in synapse assembly
    Authors: MH Berryer, G Rizki, A Nathanson, JA Klein, D Trendafilo, SG Susco, D Lam, A Messana, KM Holton, KW Karhohs, BA Cimini, K Pfaff, AE Carpenter, LL Rubin, LE Barrett
    Elife, 2023-04-21;12(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Astrocytes mediate cell non-autonomous correction of aberrant firing in human FXS neurons
    Authors: SD Sharma, BK Reddy, R Pal, TE Ritakari, JD Cooper, BT Selvaraj, PC Kind, S Chandran, DJA Wyllie, S Chattarji
    Cell Reports, 2023-04-04;42(4):112344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective
    Authors: HW Ong, Y Liang, W Richardson, ER Lowry, CI Wells, X Chen, M Silvestre, K Dempster, JA Silvaroli, JL Smith, H Wichterle, NS Pabla, SK Ultanir, AN Bullock, DH Drewry, AD Axtman
    bioRxiv : the preprint server for biology, 2023-02-10;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  15. SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
    Authors: GR Linares, Y Li, WH Chang, J Rubin-Sigl, S Mendonca, S Hong, Y Eoh, W Guo, YH Huang, J Chang, S Tu, N Dorjsuren, M Santana, ST Hung, J Yu, J Perez, M Chickering, TY Cheng, CC Huang, SJ Lee, HJ Deng, KT Bach, K Gray, V Subramanya, J Rosenfeld, SV Alworth, H Goodarzi, JK Ichida
    Cell Stem Cell, 2023-02-02;30(2):171-187.e14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Astrocytic cell adhesion genes linked to schizophrenia correlate with synaptic programs in neurons
    Authors: O Pietiläine, A Trehan, D Meyer, J Mitchell, M Tegtmeyer, V Valakh, H Gebre, T Chen, E Vartiainen, SL Farhi, K Eggan, SA McCarroll, R Nehme
    Cell Reports, 2023-01-12;42(1):111988.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
    Authors: Z Álvarez, JA Ortega, K Sato, IR Sasselli, AN Kolberg-Ed, R Qiu, KA Marshall, TP Nguyen, CS Smith, KA Quinlan, V Papakis, Z Syrgiannis, NA Sather, C Musumeci, E Engel, SI Stupp, E Kiskinis
    Cell Stem Cell, 2023-01-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states
    Authors: K Leng, IVL Rose, H Kim, W Xia, W Romero-Fer, B Rooney, M Koontz, E Li, Y Ao, S Wang, M Krawczyk, J Tcw, A Goate, Y Zhang, EM Ullian, MV Sofroniew, SPJ Fancy, MS Schrag, ES Lippmann, M Kampmann
    Nature Neuroscience, 2022-10-27;25(11):1528-1542.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state
    Authors: H Ozaki, H Suga, M Sakakibara, M Soen, N Miyake, T Miwata, S Taga, T Nagai, M Kano, K Mitsumoto, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, D Hagiwara, S Iwama, R Banno, G Iguchi, Y Takahashi, K Muguruma, H Inoue, H Arima
    Scientific Reports, 2022-10-17;12(1):17381.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro
    Authors: T Patel, J Hammelman, S Aziz, S Jang, M Closser, TL Michaels, JA Blum, DK Gifford, H Wichterle
    Nature Communications, 2022-09-15;13(1):5427.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Pharmacotherapy alleviates pathological changes in human direct reprogrammed neuronal cell model of myotonic dystrophy type 1
    Authors: MK Eltahir, M Nakamori, S Hattori, T Kimura, H Mochizuki, S Nagano
    PLoS ONE, 2022-07-01;17(7):e0269683.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
    Authors: WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song
    Scientific Reports, 2022-02-08;12(1):2082.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  23. Pleiotropic, Unique and Shared Responses Elicited by IL-6 Family Cytokines in Human Vascular Endothelial Cells
    Authors: M Lindkvist, MM Zegeye, M Grenegård, LU Ljungberg
    International Journal of Molecular Sciences, 2022-01-27;23(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus
    Authors: FC Yang, JL Vivian, C Traxler, SM Shapiro, JA Stanford
    Cell Transplantation, 2022-01-01;31(0):9636897221101.
    Species: Human
    Sample Types: Embryoid Bodies
    Applications: Bioassay
  25. A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
    Authors: Y Sonobe, J Aburas, G Krishnan, AC Fleming, G Ghadge, P Islam, EC Warren, Y Gu, MW Kankel, AEX Brown, E Kiskinis, TF Gendron, FB Gao, RP Roos, P Kratsios
    Nature Communications, 2021-10-15;12(1):6025.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. In Vitro Study of Human Immune Responses to Hyaluronic Acid Hydrogels, Recombinant Spidroins and Human Neural Progenitor Cells of Relevance to Spinal Cord Injury Repair
    Authors: C Lin, Å Ekblad-Nor, J Michaëlsso, C Götherströ, CC Hsu, H Ye, J Johansson, A Rising, E Sundström, E Åkesson
    Cells, 2021-07-06;10(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Development of a fully human assay combining NGN2-inducible neurons co-cultured with iPSC-derived astrocytes amenable for electrophysiological studies
    Authors: PY Shih, M Kreir, D Kumar, F Seibt, F Pestana, B Schmid, B Holst, C Clausen, R Steeg, B Fischer, J Pita-Almen, A Ebneth, A Cabrera-So
    Stem Cell Research, 2021-05-24;54(0):102386.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  28. TNF-&alpha and &alpha-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration
    Authors: K Russ, G Teku, L Bousset, V Redeker, S Piel, E Savchenko, Y Pomeshchik, J Savistchen, TC Stummann, C Azevedo, A Collin, S Goldwurm, K Fog, E Elmer, M Vihinen, R Melki, L Roybon
    Cell Reports, 2021-03-23;34(12):108895.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Arginine vasopressin-Venus reporter mice as a tool for studying magnocellular arginine vasopressin neurons
    Authors: D Hagiwara, M Tochiya, Y Azuma, T Tsumura, Y Hodai, Y Kawaguchi, T Miyata, T Kobayashi, M Sugiyama, T Onoue, H Takagi, Y Ito, S Iwama, H Suga, R Banno, H Arima
    Peptides, 2021-02-26;139(0):170517.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
    Authors: E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer
    BMC molecular and cell biology, 2021-02-18;22(1):13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
    Authors: C Wang, M Zhang, G Garcia, E Tian, Q Cui, X Chen, G Sun, J Wang, V Arumugaswa, Y Shi
    Cell Stem Cell, 2021-01-04;28(2):331-342.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia
    Authors: Y Mou, Y Dong, Z Chen, KR Denton, MO Duff, C Blackstone, SC Zhang, XJ Li
    Acta neuropathologica communications, 2020-12-07;8(1):214.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Synergistic effect of CNTF and GDNF on directed neurite growth in chick embryo dorsal root ganglia
    Authors: V Mashanov, A Alwan, MW Kim, D Lai, A Poerio, YM Ju, JH Kim, JJ Yoo
    PLoS ONE, 2020-10-05;15(10):e0240235.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Astroglial FMRP deficiency cell-autonomously up-regulates miR-128 and disrupts developmental astroglial mGluR5 signaling
    Authors: Y Men, L Ye, RD Risgaard, V Promes, X Zhao, M Paukert, Y Yang
    Proc. Natl. Acad. Sci. U.S.A., 2020-09-21;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro
    Authors: KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri
    Cells, 2020-08-21;9(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay, Cell Culture
  36. Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single-cell transcriptome analysis
    Authors: P Teotia, M Niu, I Ahmad
    Stem Cells, 2020-06-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation
    Authors: M Grosch, S Ittermann, E Rusha, T Greisle, C Ori, DJ Truong, AC O'Neill, A Pertek, GG Westmeyer, M Drukker
    BMC Biol., 2020-04-22;18(1):42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  38. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
    Authors: M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappellett, M Zini, S Goldwurm, L Roybon
    Acta Neuropathol Commun, 2019-12-16;7(1):208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. V2a interneuron differentiation from mouse and human pluripotent stem cells
    Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
    Nat Protoc, 2019-10-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming
    Authors: KN Babos, KE Galloway, K Kisler, M Zitting, Y Li, Y Shi, B Quintino, RH Chow, BV Zlokovic, JK Ichida
    Cell Stem Cell, 2019-09-12;25(4):486-500.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  41. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
    Authors: Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland
    Nat. Neurosci., 2019-01-14;22(2):180-190.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
    Authors: JR Klim, LA Williams, F Limone, I Guerra San, BN Davis-Duse, DA Mordes, A Burberry, MJ Steinbaugh, KK Gamage, R Kirchner, R Moccia, SH Cassel, K Chen, BJ Wainger, CJ Woolf, K Eggan
    Nat. Neurosci., 2019-01-14;22(2):167-179.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Blocking p62/SQSTM1-dependent SMN degradation ameliorates Spinal Muscular Atrophy disease phenotypes
    Authors: N Rodriguez-, A Parkhitko, T Grass, RM Gibbs, EM Norabuena, N Perrimon, R Singh, LL Rubin
    J. Clin. Invest., 2018-06-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Circadian Regulation of Mitochondrial Dynamics in Retinal Photoreceptors
    Authors: JY Chang, L Shi, ML Ko, GY Ko
    J. Biol. Rhythms, 2018-04-01;33(2):151-165.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  45. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
    Authors: MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis
    Cell Stem Cell, 2018-03-15;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Human bone marrow harbors cells with neural crest-associated characteristics like human adipose and dermis tissues
    Authors: C Coste, V Neirinckx, A Sharma, G Agirman, B Rogister, J Foguenne, F Lallemend, A Gothot, S Wislet
    PLoS ONE, 2017-07-06;12(7):e0177962.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Expression of Pluripotency Markers in Non-pluripotent Human Neural Stem and Progenitor Cells
    Authors: PH Vincent, E Benedikz, P Uhlen, O Hovatta, E Sundström
    Stem Cells Dev., 2017-03-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. High hydrostatic pressure enables almost 100% refolding of recombinant human ciliary neurotrophic factor from inclusion bodies at high concentration
    Authors: Q Wang, Y Liu, C Zhang, F Guo, C Feng, X Li, H Shi, Z Su
    Protein Expr. Purif, 2017-03-18;133(0):152-159.
    Species: Human
    Sample Types:
  49. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
    Authors: Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A
    Development, 2015-02-15;142(4):633-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
    Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
    Nat Commun, 2015-01-12;6(0):5999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Chicken embryos as a potential new model for early onset type I diabetes.
    Authors: Shi L, Ko M, Huang C, Park S, Hong M, Wu C, Ko G
    J Diabetes Res, 2014-07-13;2014(0):354094.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models.
    Authors: Barmada, Sami J, Serio, Andrea, Arjun, Arpana, Bilican, Bilada, Daub, Aaron, Ando, D Michae, Tsvetkov, Andrey, Pleiss, Michael, Li, Xingli, Peisach, Daniel, Shaw, Christop, Chandran, Siddhart, Finkbeiner, Steven
    Nat Chem Biol, 2014-06-29;10(8):677-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Involvement of ER stress in dysmyelination of Pelizaeus-Merzbacher Disease with PLP1 missense mutations shown by iPSC-derived oligodendrocytes.
    Authors: Numasawa-Kuroiwa Y, Okada Y, Shibata S, Kishi N, Akamatsu W, Shoji M, Nakanishi A, Oyama M, Osaka H, Inoue K, Takahashi K, Yamanaka S, Kosaki K, Takahashi T, Okano H
    Stem Cell Reports, 2014-04-24;2(5):648-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Canine epidermal neural crest stem cells: characterization and potential as therapy candidate for a large animal model of spinal cord injury.
    Authors: Gericota B, Anderson J, Mitchell G, Borjesson D, Sturges B, Nolta J, Sieber-Blum M
    Stem Cells Transl Med, 2014-01-17;3(3):334-45.
    Species: Canine
    Sample Types: Whole Cells
    Applications: Bioassay
  55. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
    Authors: Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L
    Cell Stem Cell, 2013-04-18;12(6):713-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. The reactivity, distribution and abundance of Non-astrocytic Inner Retinal Glial (NIRG) cells are regulated by microglia, acute damage, and IGF1.
    Authors: Zelinka C, Scott M, Volkov L, Fischer A
    PLoS ONE, 2012-09-04;7(9):e44477.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  57. Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes.
    Authors: Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM
    Stem Cells Dev., 2011-07-26;21(3):404-10.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina.
    Authors: Ko ML, Jian K, Shi L, Ko GY
    J. Neurochem., 2009-01-24;108(6):1607-20.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  59. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants.
    Authors: Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJ, Fullmer KR, Bush RA
    Proc. Natl. Acad. Sci. U.S.A., 2006-02-27;103(10):3896-901.
    Species: Human
    Sample Types: Serum
    Applications: ELISA (Capture)
  60. The N-terminal cytokine binding domain of LIFR is required for CNTF binding and signaling.
    Authors: He W, Gong K, Smith DK, Ip NY
    FEBS Lett., 2005-08-15;579(20):4317-23.
    Species: Human
    Sample Types: Peptide, Whole Cells
    Applications: Binding Assay, Bioassay
  61. Transitin, a nestin-related intermediate filament, is expressed by neural progenitors and can be induced in Muller glia in the chicken retina.
    Authors: Fischer AJ, Omar G
    J. Comp. Neurol., 2005-03-28;484(1):1-14.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  62. PACAP promotes sensory neuron differentiation: blockade by neurotrophic factors.
    Authors: Nielsen KM, Chaverra M, Hapner SJ, Nelson BR, Todd V, Zigmond RE, Lefcort F
    Mol. Cell. Neurosci., 2004-04-01;25(4):629-41.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Membrane distal cytokine binding domain of LIFR interacts with soluble CNTFR in vitro.
    Authors: He W, Gong K, Zhu G, Smith DK
    FEBS Lett., 2002-03-13;514(2):214-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

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