Rat IL-17/IL-17A Antibody Summary
(Met1-Ser150,I46L) and (Met1-161)
Accession # Q61453
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-17/IL-17A
Rat IL-17A/F is an approximately 37 kDa, secreted, disulfide-linked glycosylated heterodimeric protein comprised of
two members of the IL-17 family of cytokines, IL-17A and IL-17F (1, 2). Members
of this family demonstrate a structural motif termed a cysteine knot that also
characterizes a large superfamily of growth factors such as TGF-beta (1).
Although most cysteine knot superfamily members use three intrachain disulfide
bonds to create a knot, IL-17 family molecules generate the same structural
form with only two disulfide links (1, 3-5). Mature rat IL-17A and IL-17F share
60% and 59% amino acid sequence identity with human and 61% and 90% with mouse
IL-17A and IL-17F, respectively. They also share 50% aa sequence identity with
each other (1). IL-17A/F heterodimer and the IL-17A and IL-17F homodimers are
produced by IL-23 activated Th17 cells (1, 6-10, 14). The widely expressed
receptors IL-17 RA and IL-17 RC form a heterodimer for the binding of
IL-17A
and IL-17F, as well as the heterodimeric IL-17A/F (6, 11, 12). IL-17A/F
is a biologically active protein that induces chemokine production and airway
neutrophilia with intermediate potency between IL-17A (most potent) and IL-17F
(least potent) (7, 12). It is up-regulated in immune cells during inflammatory
arthritis and contributes to disease severity (13).
- Wright, J.F. et al. (2007) J. Biol. Chem. 282:13447.
- Chang, S.H. and C. Dong (2007) Cell Res. 17:435.
- Kawaguchi, M. et al. (2004) J. Allergy Clin. Immunol. 114:1265.
- Kolls, J.K. and A. Linden (2004) Immunity 21:467.
- Gu, C. et al. (2013) Cytokine 64:477.
- Cheung, P.F.Y. et al. (2008) J. Immunol. 180:5625.
- Liang, S.C. et al. (2007) J. Immunol. 179:7791.
- Ouyang, W. et al. (2008) Immunity 28:454.
- Steinman, L. (2007) Nat. Med. 13:139.
- Hunter, C.A. (2005) Nat. Rev. Immunol. 5:521.
- Kuestner, R.E. et al. (2007) J. Immunol. 179:5462.
- Wright, J.F. et al. (2008) J. Immunol. 181:2799.
- Sarkar, S. et al. (2014) Clin. Exp. Immunol. 177:652.
- Spolski, R. et al. (2009) Eur. J. Immunol. 3: 658.
Product Datasheets
Citation for Rat IL-17/IL-17A Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Therapeutic effects and mechanisms of fecal microbiota transplantation on EAE partly through HPA axis-mediated neuroendocrine regulation
Authors: Xu, D;Ren, L;Zhang, W;Wu, S;Yu, M;He, X;Wei, Z;
Heliyon
Species: Rat
Sample Types: Serum
Applications: ELISA Capture
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