Rat ICAM-1/CD54 Alexa Fluor® 350-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: ICAM-1/CD54

Intercellular Adhesion Molecule-1 (ICAM-1, CD54), binds the leukocyte integrins LFA-1 and Mac-1. ICAM-1 expression is weak on leukocytes, epithelial and resting endothelial cells, as well as some other cell types, but expression can be stimulated by IFN-gamma, TNF-alpha, IL-1 beta, and lipolysaccharide (LPS). Rat and human ICAM-1 share approximately 52% amino acid identity. Rat and mouse ICAM-1 share approximately 52% amino acid identity.

Soluble ICAM-1 is found in a biologically active form in serum, probably as a result of proteolytic cleavage from the cell surface, and is elevated in patients with various inflammatory syndromes such as septic shock, leukocyte adhesion deficiency syndrome (LAD), cancer, and transplantation.

Product Datasheets

Related Research Areas

• Adhesion Molecules
• Adhesion Molecules in Angiogenesis
• Adhesion Molecules on Endothelial Cells
• Adhesion Molecules on VSMC
• Adhesive Interactions in Allergy and Asthma
• Adipose-derived Stem Cell Markers
• B Cell Chemotaxis, Migration, and Adhesion
• Dendritic Cell Adhesion and Migration
• Endothelial Cell Markers
• Immunoglobulin Superfamily CAMs
• Mesenchymal Stem Cell Markers
• Monocyte Markers
• Myeloid-derived Suppressor Cells (MDSC)
• Platelet Adhesion Molecules
• Regulatory T Cells (Tregs)
• T Cell Migration/Adhesion