Rat CCR1 (NP_065417) VersaClone cDNA

Rat CCR1 (NP_065417) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CCR1

CCR1 is a G protein-coupled receptor member of the CC chemokine subfamily of receptors. Human CCR1 is 355 amino acids (aa) in length and has a predicted molecular weight of 41 kDa. Mouse and rat CCR1 share 80% aa sequence identity with the human protein. Most chemokine receptors exhibit promiscuous binding properties whereby several different chemokines signal through the same receptor. Chemokine ligand receptor binding results in G protein activation as well as the activation of downstream signaling cascades, including the Akt and NFkB pathways. Chemokine receptors mediate the chemotactic actions of chemokine ligands and activation of these receptors leads to cytoskeleton rearrangement and chemotactic cell migration.

Related Research Areas

• CC Chemokines and Receptors
• Chemokine Receptors
• Chemokines and Receptors in Allergy and Asthma
• Chemokines and Receptors in Angiogenesis
• G Protein-Coupled Receptors in Immune Responses
• Monocyte Markers
• Multiple Myeloma
• Platelet Cytokine and Growth Factor Receptors
• Receptors in the Jak/STAT Pathway
• T Cell Migration/Adhesion
• Th1 Cells