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Raloxifene hydrochloride

Catalog #: 2280
2 Citations Datasheet
Catalog # Availability Size / Price Qty
2280/50
Raloxifene hydrochloride | CAS No. 82640-04-8 | Estrogen and Related Receptor Modulators
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Description: Selective estrogen receptor modulator (SERM)
Alternative Names: LY 139481,Keoxifene

Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM.

Technical Data

M.Wt:
510.04
Formula:
C28H27NO4S.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
82640-04-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Estrogen receptor-1 is a key regulator of HIV-1 latency that imparts gender-specific restrictions on the latent reservoir
    B Das, C Dobrowolsk, B Luttge, S Valadkhan, N Chomont, R Johnston, P Bacchetti, R Hoh, M Gandhi, SG Deeks, E Scully, J Karn
    Proc. Natl. Acad. Sci. U.S.A., 2018;115(33):E7795-E7804.
  2. Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line.
    Fitzpatrick et al.
    Endocrinology, 1999;140:3928
  3. Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator.
    Bryant
    Rev.Endocr.Metab.Disord., 2001;2:129
  4. Tamoxifen and ralox. suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake.
    Todorova et al.
    Cancer Chemother. Pharmacol., 2011;67:285
  5. Effects of ralox. hydrochloride on endometrial cancer cells in vitro.
    Hibner et al.
    Gynecologic Oncol., 2004;93:642

Product Datasheets

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Citations for Raloxifene hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Raloxifene hydrochloride include:

2 Citations: Showing 1 - 2

  1. Pharmacological characterization of AS2690168, a novel small molecule RANKL signal transduction inhibitor.
    Authors: Morikawa Et al.
    Eur.J.Pharmacol.  2022;924:174941
  2. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia.
    Authors: Nicholson Et al.
    Am J Physiol Heart Circ Physiol  2015;193:722

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