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RAGE antagonist peptide

Catalog #: 6259
2 Citations Datasheet
Catalog # Availability Size / Price Qty
6259/1
RAGE antagonist peptide
1 Image
Description: RAGE antagonist

Purity: ≥95%

Product Details
Citations (2)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

RAGE antagonist peptide is a receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.

Technical Data

M.Wt:
1272.56
Formula:
C57H101N13O17S
Sequence:
ELKVLMEKEL

(Modifications: Glu-1 = N-terminal Ac, Leu-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
1092460-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The receptor for advanced glycation end products is required for �-catenin stabilization in a chemical-induced asthma model.
    Yao et al.
    Br.J.Pharmacol., 2016;173:2600
  2. Epithelial HMGB1 Delays Skin Wound Healing and Drives Tumor Initiation by Priming Neutrophils for NET Formation
    E Hoste, C Maueröder, L van Hove, L Catrysse, HK Vikkula, M Sze, B Maes, D Karjosukar, L Martens, A Gonçalves, E Parthoens, R Roelandt, W Declercq, I Fuentes, F Palisson, S Gonzalez, JC Salas-Alan, L Boon, P Huebener, KW Mulder, K Ravichandr, Y Saeys, RF Schwabe, G van Loo
    Cell Rep, 2019;29(9):2689-2701.e4.
  3. S100P-derived RAGE antagonistic peptide reduces tumor growth and metastasis.

    Clin. Cancer Res., 2012-06-20;18(16):4356-64.

Product Datasheets

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Citations for RAGE antagonist peptide

The citations listed below are publications that use Tocris products. Selected citations for RAGE antagonist peptide include:

2 Citations: Showing 1 - 2

  1. Blood-Borne Microparticles Are an Inflammatory Stimulus in Type 2 Diabetes Mellitus
    Authors: Thom Et al.
    Immunohorizons  2023;7:71
  2. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
    Authors: Uderhardt Et al.
    Cell  2019;177:541

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