R18
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Description: Inhibitor of 14.3.3 proteins
Purity: ≥95%
Biological Activity
R18 is an antagonist of 14.3.3 proteins (KD ≈80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation. Blocks the ability of 14.3.3 to bind to target proteins such as Raf-1, Bad, ASK1 and exoenzyme S.Technical Data
M.Wt:
2309.69
Formula:
C101H157N27O29S3
Sequence:
PHCVPRDLSWLDLEANMCLP
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
211364-78-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Isolation of high-affinity peptide antagonists of 14.3.3 proteins by phage display.
Wang et al.
Biochemistry, 1999;38:12499 -
14.3.3 proteins mediate an essential anti-apoptotic signal.
Masters and Fu
J.Biol.Chem., 2001;276:45193 -
Survival-promoting functions of 14.3.3 proteins.
Masters et al.
Biochem.Soc.Transactions, 2002;30:360
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