(R)-Norketamine hydrochloride
Chemical Name: (R)-2-Amino-2-(2-chlorophenyl)cyclohexan-1-one hydrochloride
Purity: ≥98%
Biological Activity
(R)-Norketamine hydrochloride is a NMDA receptor modulator. Metabolite of Ketamine hydrochloride. Decreases intracellular D-serine concentration (IC50 = 91 nM) and alters serine racemase expression in PC-12 cells. Exhibits analgesic effects in rat pain models.S-enantiomer and racemate also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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KA metabolites enantioselectively decrease intracellular D-serine concentrations in PC-12 cells.
Singh et al.
PLoS One, 2016;11:e0149499 -
Effects of norKA enantiomers in rodent models of persistent pain.
Holtman et al.
Pharmacol.Biochem.Behav., 2008;909:676
Product Datasheets
Citation for (R)-Norketamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (R)-Norketamine hydrochloride include:
1 Citation: Showing 1 - 1
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(R)-Ketamine induces a greater increase in prefrontal 5-HT release than (S)-Ketamine and Ketamine Metabolites via an AMPA receptor-independent mechanism.
Authors: Ago Et al.
Int J Neuropsychopharmacol 2019;22:665
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