(R)-(+)-Etomoxir sodium salt
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Description: Carnitine palmitoyltransferase I (CPT1) inhibitor
Chemical Name: (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Purity: ≥98%
Biological Activity
(R)-(+)-Etomoxir sodium salt is an inhibitor of carnitine palmitoyltransferase I (CPT1); inhibits β-oxidation in mitochondria. Shown to inhibit cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells.Technical Data
M.Wt:
320.74
Formula:
C15H18ClNaO4
Solubility:
Soluble to 20 mM in water and to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
828934-41-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism
JC Schell, DR Wisidagama, C Bensard, H Zhao, P Wei, J Tanner, A Flores, J Mohlman, LK Sorensen, CS Earl, KA Olson, R Miao, TC Waller, D Delker, P Kanth, L Jiang, RJ DeBerardin, MP Bronner, DY Li, JE Cox, HR Christofk, WE Lowry, CS Thummel, J Rutter
Nat. Cell Biol., 2017;19(9):1027-1036. -
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells.
Xu et al.
J.Lipid Res., 2003;44:415 -
Stereospecificity of the inhibition of etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes.
Agius et al.
Biochem.Pharmacol., 1991;42:1717 -
Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor.
Rupp et al.
FASEB J., 1992;6:2349 -
Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection.
Christoph Wilhelm, Oliver J Harrison, Vanessa Schmitt, Martin Pelletier, Sean P Spencer, Joseph F Urban, Michelle Ploch, Thirumalai R Ramalinga, Richard M Siegel, Yasmine Belkaid
The Journal of Experimental Medicine, 2016;0(0):1540-9538. -
Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
Cell Stem Cell, 2020;0(0):.
Product Datasheets
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Citations for (R)-(+)-Etomoxir sodium salt
The citations listed below are publications that use Tocris products. Selected citations for (R)-(+)-Etomoxir sodium salt include:
16 Citations: Showing 1 - 10
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Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysis.
Authors: Elizabeth A Et al.
STAR Protoc 2022;3:101389
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α1-Adrenergic receptors increase glucose oxidation under normal and ischemic conditions in adult mouse cardiomyocytes.
Authors: Robert S Et al.
J Recept Signal Transduct Res 2021;41:138-144
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β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME.
Authors: Scott I Et al.
Cell Rep 2021;37:109883
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The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Authors: Santosh Et al.
Cell Rep 2021;34:108869
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Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Authors: Eduards Et al.
Int J Mol Sci 2021;22
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Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.
Authors: Jonas Thue Et al.
Cell 2021;184:3502-3518.e33
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Elevated CO2 Levels Delay Skeletal Muscle Repair by Increasing Fatty Acid Oxidation.
Authors: Navdeep S Et al.
Front Physiol 2021;11:630910
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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes.
Authors: Roberta Et al.
J Vis Exp 2021;
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Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Authors: Ryan M Et al.
Cell Rep 2020;30:2889-2899.e6
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TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells.
Authors: Carine Et al.
Nat Commun 2020;11:454
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Inhibition of Fatty Acid Oxidation Promotes Macrophage Control of Mycobacterium tuberculosis.
Authors: Joel D Et al.
MBio 2020;11
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Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells.
Authors: Hamida Et al.
Immunity 2019;51:169-184.e5
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.
Authors: Matthew D Et al.
Cell Metab 2017;26:884-896.e5
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Inhibition of acetyl-CoA carboxylases by soraphen A prevents lipid accumulation and adipocyte differentiation in 3T3-L1 cells.
Authors: Janos Et al.
Eur J Pharmacol 2016;780:202-8
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Cellular Metabolism and Dose Reveal Carnitine-Dependent and -Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells.
Authors: Dallas R Et al.
J Cell Physiol 2016;231:1804-13
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Fatty acid synthase is a metabolic oncogene targetable in malignant peripheral nerve sheath tumors.
Authors: Nancy Et al.
Neuro Oncol 2015;17:1599-608
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etomoxir was used as a CPT1 inhibitor
By Anonymous
on 10/05/2018
Etomoxir was used as a CPT1 inhibitor in endothelial cells. The data was shown in the publication PubMed ID 29429925.
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