R 7050
Chemical Name: 8-Chloro-4-(phenylthio)-1-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]quinoxaline
Purity: ≥98%
Biological Activity
R 7050 is an inhibitor of TNF-α receptor 1 (TNFR1) signaling; blocks TNFR1 association with TRADD and RIP1. Inhibits TNF-α-induced NF-κB and MAPK signaling pathway activation. Attenuates intracerebral hemorrhage-induced neurovascular injury in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A class of small molecules that inhibit TNFα-induced survival and death pathways via prevention of interactions between TNFαRI, TRADD, and RIP1.
Gururaja et al.
Chem.Biol., 2007;14:1105 -
TNF-α receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice.
King et al.
Neurosci.Lett., 2013;542:92
Product Datasheets
Citations for R 7050
The citations listed below are publications that use Tocris products. Selected citations for R 7050 include:
3 Citations: Showing 1 - 3
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Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.
Authors: Vicente Et al.
Int J Mol Sci 2022;23
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Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering.
Authors: Dominic Et al.
ACS Nano 2020;14:10027-10044
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Pore-forming toxin-mediated ion dysregulation leads to death receptor-independent necroptosis of lung epithelial cells during bacterial pneumonia.
Authors: Gonzalez-Juarbe Et al.
Cell Death Differ 2017;24:917
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