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QX 314 chloride

Catalog #: 2313
9 Citations Datasheet
Catalog # Availability Size / Price Qty
2313/50
QX 314 chloride | CAS No. 5369-03-9 | Voltage-gated Sodium Channel Blockers
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Description: Na+ channel blocker

Chemical Name: N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride

Purity: ≥99%

Product Details
Citations (9)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.

Technical Data

M.Wt:
298.85
Formula:
C16H27N2OCl
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Store at RT
CAS No:
5369-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Maternal and Early Postnatal Immune Activation Produce Dissociable Effects on Neurotransmission in mPFC-Amygdala Circuits
    Y Li, G Missig, BC Finger, SM Landino, AJ Alexander, E Mokler, J Robbins, Y Manasian, W Kim, KS Kim, CJ McDougle, WA Carlezon, VY Bolshakov
    J. Neurosci., 2018;0(0):.
  2. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.
    Stichartz et al.
    J.Gen.Physiol., 1973;62:37
  3. QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons.
    Alreja and Aghajanian
    Brain Res., 1994;639:320
  4. Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells.
    Perkins and Wong
    J.Neurophysiol., 1995;73:911

Product Datasheets

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Citations for QX 314 chloride

The citations listed below are publications that use Tocris products. Selected citations for QX 314 chloride include:

9 Citations: Showing 1 - 9

  1. Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.
    Authors: Birdsong Et al.
    Elife  2019;8
  2. Probing nicotinic acetylcholine receptor function in mouse brain slices via laser flash photolysis of photoactivatable nicotine.
    Authors: Arvin Et al.
    J Vis Exp  2019;143:e58873
  3. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
    Authors: Collins Et al.
    Neuron  2018;98:366
  4. CAST/ELKS Proteins Control Voltage-Gated Ca2+ Channel Density and Synaptic Release Probability at a Mammalian Central Synapse.
    Authors: Dong Et al.
    Cell Rep  2018;24:284
  5. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
    Authors: Hull
    Cold Spring Harb Protoc  2017;2017
  6. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    Mol Pain  2015;9:115
  7. hPSC-derived maturing GABAergic interneurons ameliorate seizures and abnormal behavior in epileptic mice.
    Authors: Cunningham Et al.
    Cell Stem Cell  2014;15:559
  8. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
    Authors: Wood Et al.
    Front Cell Neurosci  2009;29:12440
  9. DArgic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
    Authors: Wang Et al.
    Neuron  2006;50:443

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