Pyridone 6

Biological Activity

Pyridone 6 is a potent pan-JAK inhibitor; ATP-competitive inhibitor of JAK 1/2/3 and Tyk2 (IC₅₀ values are 1, 5, 15 and 1 nM, respectively). Inhibits other kinases tested at 130 nM to >10 μM. Inhibits IL-2- and IL-4-dependent proliferation of CTLL cells and blocks STAT5 phosphorylation. Also inhibits Th1 and Th2 development, and promotes Th17 differentiation from naive T cells. When used in combination with Retinoic acid, LY 294002 and CCG 1423, it induces intermediate mesoderm differentiation from ESCs. Inhibits growth of primary myeloma cells grown in the presence of bone marrow stromal cells. Cell-permeable.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.
   Mae et al.
   Biochem.Biophys.Res.Commun., 2010;393:877
2. Photochemical preparation of a pyridone containing tetracycle: a Jak protein kinase inhibitor.
   Thompson et al.
   Bioorg.Med.Chem.Lett., 2002;12:1219

Product Datasheets