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Pyr 10

Catalog #: 6941 Datasheet
Catalog # Availability Size / Price Qty
6941/50
6941/10
Pyr 10 | CAS No. 1315323-00-2 | TRPC Channel Blockers
1 Image
Description: Selective TRPC3 inhibitor

Chemical Name: N-[4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-4-methylbenzenesulfonamide

Purity: ≥98%

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Biological Activity

Pyr 10 is a TRPC3 (transient receptor potential canonical 3) channel inhibitor (IC50 = 0.72 μM for TRPC3 mediated calcium entry in vitro), which displays approximately 18-fold selectivity for TRPC3-mediated receptor operated calcium entry (ROCE) over STIM1/Orai1-mediated store operated calcium entry (SOCE). Pyr 10 inhibits NFATc3 activation and inhibits proliferation of rat ventricular cardiac fibroblasts.

Technical Data

M.Wt:
449.37
Formula:
C18H13F6N3O2S
Solubility:
Soluble to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1315323-00-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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