PX 12
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Purity: ≥99%
Biological Activity
PX 12 is a thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype
Nat Immunol, 2016;0(0):. -
BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
Zhu J, Sun L, Lin S
J. Exp. Clin. Cancer Res., 2012;31(0):31. -
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
You B, Shin H, Park W
Int J Oncol, 2014;44(1):301-8. -
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Shin H, You B, Park W
Oncol Lett, 2013;6(6):1804-1810. -
Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides.
Kirkpatrick et al.
Biochem.Pharmacol., 1998;55:987 -
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation.
Welsh et al.
Mol.Cancer.Ther., 2003;2:235 -
The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging.
Jordan et al.
Clin.Cancer Res., 2005;11:529
Product Datasheets
Citations for PX 12
The citations listed below are publications that use Tocris products. Selected citations for PX 12 include:
2 Citations: Showing 1 - 2
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PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin Et al.
Oncol Lett 2013;6:1804
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BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells.
Authors: Zhu Et al.
Cell Death Differ 2012;31:31
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