Puromycin dihydrochloride

Catalog #: 4089
16 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
4089/50

Puromycin dihydrochloride | CAS No. 58-58-2 | DNA, RNA and Protein Synthesis Inhibitors

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Description: Protein synthesis inhibitor

Chemical Name: 3'-[α-Amino-p-methoxyhydrocinnamamido]-3'-deoxy-N,N-dimethyladenosine dihydrochloride

Purity: ≥98%

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Product Details

Citations (16)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Puromycin dihydrochloride is a protein synthesis inhibitor; leads to the premature release of polypeptide chains as polypeptidyl purine derivatives. Analog of the 3' end of aminoacyl-tRNA. Aminonucleoside antibiotic. Inhibits translation in both in vitro and in vivo systems. Also inhibits the transport of proteins into the mitochondria in vitro.

Technical Data

M.Wt:

544.43

Formula:

C₂₂H₂₉N₇O₅.2HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

58-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Dasgupta S, Castro L, Dulman R, Yang C, Schmidt M, Ferro E, Fricker L
PLoS ONE, 2014;9(7):e103604.
AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
Ma S, Mao L, Deng W, Li Y, Bu L, Yu G, Zhang W, Sun Z
Am J Transl Res, 0;9(2):507-519.
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
M Varela-Eir, A Varela-Váz, A Guitián-Ca, CL Paíno, V Mato, R Largo, T Aasen, A Tabernero, E Fonseca, M Kandouz, JR Caeiro, A Blanco, MD Mayán
Cell Death Dis, 2018;9(12):1166.
Up-regulation of syncytin-1 contributes to TNF-ï¿½-enhanced fusion between OSCC and HUVECs partly via Wnt/?-catenin-dependent pathway
TL Yan, M Wang, Z Xu, CM Huang, XC Zhou, EH Jiang, XP Zhao, Y Song, K Song, Z Shao, K Liu, ZJ Shang
Sci Rep, 2017;7(0):40983.
Puromycin inhibits protein import into mitochondria by interfering with an intramitochondrial ATP-dependent reaction.
Price and Verner
Biochim.Biophys.Acta., 1993;1150:89

Product Datasheets

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Citations for Puromycin dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Puromycin dihydrochloride include:

16 Citations: Showing 1 - 10

Two distinct trophectoderm lineage stem cells from human pluripotent stem cells.
Authors: Balaji M Et al.
J Biol Chem 2021;296:100386
PCSK9 regulates the NODAL signaling pathway and cellular proliferation in hiPSCs.
Authors: Nabil G Et al.
Stem Cell Reports 2021;16:2958-2972
CT45A1 promotes the metastasis of osteosarcoma cells in vitro and in vivo through β-catenin.
Authors: Tao Et al.
Cell Death Dis 2021;12:650
Local miRNA-Dependent Translational Control of GABAAR Synthesis during Inhibitory Long-Term Potentiation.
Authors: Mark L Et al.
Cell Rep 2020;31:107785
FUS contributes to mTOR-dependent inhibition of translation.
Authors: Chantelle F Et al.
J Biol Chem 2020;295:18459-18473
FUS contributes to mTOR-dependent inhibition of translation.
Authors: Chantelle F Et al.
J Biol Chem 2020;295:18459-18473
An Anti-PSMA Immunotoxin Reduces Mcl-1 and Bcl2A1 and Specifically Induces in Combination with the BAD-Like BH3 Mimetic ABT-737 Apoptosis in Prostate Cancer Cells.
Authors: Philipp Et al.
Cancers (Basel) 2020;12
SIGMAR1/Sigma-1 receptor ablation impairs autophagosome clearance.
Authors: Yang Et al.
Autophagy 2019;:1
Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.
Authors: Yu Et al.
PLoS One 2019;14:e0210608
AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
Authors: Ma Et al.
Am J Transl Res. 2017;9:507

Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation.
Authors: Luke A Et al.
Elife 2016;5

WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.
Authors: Leung Et al.
Development 2016;143:398

Reduced Levels of Proteasome Products in a Mouse Striatal Cell Model of Huntington's Disease.
Authors: Dasgupta Et al.
PLoS One 2015;10:e0145333

All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation.
Authors: Zhu Et al.
J Neurosci 2015;10:e0143255

Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604

Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA.
Authors: Dobrikov Et al.
Mol Cell Biol 2014;34:439

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