(Z)-Pugnac
Chemical Name: O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
Purity: ≥98%
Biological Activity
(Z)-Pugnac is an O-GlcNAc-β-N-acetylglucosaminidase (O-GlcNAcase) and β-hexosaminidase inhibitor (Ki values are 46 and 36 nM respectively) that increases O-GlcNAc levels ~ 2-fold in HT29 cells. Z-linked isomer is more potent than the E isomer.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Purification and characterization of an O-GlcNAc selective N-acetyl-β-D-glucosaminidase from rat spleen cytosol.
Dong and Hart
J.Biol.Chem., 1994;269:19321 -
O-GlcNAcase uses substrate-assisted catalysis.
Macauley et al.
J.Biol.Chem., 2005;280:25313 -
Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry.
Perreira et al.
Bioorg.Med.Chem., 2006;14:837
Product Datasheets
Citations for (Z)-Pugnac
The citations listed below are publications that use Tocris products. Selected citations for (Z)-Pugnac include:
2 Citations: Showing 1 - 2
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Higher O-GlcNAc Levels Are Associated with Defects in Progenitor Proliferation and Premature Neuronal Differentiation during in-Vitro Human Embryonic Cortical Neurogenesis.
Authors: Parween Et al.
Front Cell Neurosci 2018;11:415
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O-GlcNAcylation of ATG4B positively regulates autophagy by increasing its hydroxylase activity.
Authors: Jo Et al.
Oncotarget 2016;7:57186
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