PSEM 89S

Catalog #: 6426 Datasheet

Catalog #	Availability	Size / Price	Qty
6426/5
6426/25

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Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Chemical Name: N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PSEM 89S is a PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ chimeric ion channel agonist (EC₅₀ values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAM^L141F,Y115F-5-HT₃ chimeric ion channels and inhibits activity of neurons expressing PSAM^L141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAM^L141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ are available from Addgene.

Technical Data

M.Wt:

404.38

Formula:

C₁₆H₂₂N₂O₃.CF₃CO₂H

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in water

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1336913-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Background References

Chemical and genetic engineering of selective ion channel-ligand interactions.
Magnus et al.
Science, 2011;333:1292
Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea.
Cerritelli et al.
PLoS One, 2016;11:e0153187

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