PSEM 308 hydrochloride

Catalog #: 6425 Datasheet

Catalog #	Availability	Size / Price	Qty
6425/25
6425/5

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Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Chemical Name: 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride

Purity: ≥98%

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAM^L141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAM^L141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAM^L141F,Y115F-5-HT₃ ion channels.

Recommended concentration for use in mice is 5 mg/kg or lower.

Plasmid vectors for the transfection of cells with PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ are available from Addgene.

Technical Data

M.Wt:

303.83

Formula:

C₁₇H₂₁N₃.HCl

Solubility:

Soluble to 20 mM in DMSO and to 20 mM in ethanol with gentle warming

Purity:

≥98%

Storage:

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Background References

Regulation of neuronal input transformations by tunable dendritic inhibition.
Lovett-Barron et al.
Nat.Neurosci., 2012;15:423
Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons.
Satoh et al.
Neuron, 2016;89:1046
Deconstruction of a neural circuit for hunger.
Atasoy et al.
Nature, 2012;488:172
Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats.
Hirschberg et al.
Elife, 2017;6:e29808

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