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Proteome Profiler Human Phospho-RTK Array Kit

Catalog #: ARY001B
274 Citations 8 Reviews Datasheet
Contains 4 membranes - each spotted in duplicate with 49 different RTK antibodies
Catalog # Availability Size / Price Qty
ARY001B
Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line.
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Citations (274)
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Proteome Profiler Human Phospho-RTK Array Kit Summary

Kit Summary

A membrane-based antibody array for the parallel determination of the relative phosphorylation of human receptor tyrosine kinases. Validated for analyte detection in cell lysates.

Troubleshooting Guide

Key Benefits

  • Detects phosphorylation of 49 human receptor tyrosine kinases simultaneously
  • Requires no specialized equipment

 

Principle of the Assay

The Proteome Profiler Human Phospho-RTK Array Kit is a membrane-based sandwich immunoassay. Capture antibodies spotted in duplicate on nitrocellulose membranes bind to specific target proteins present in the sample (Step 1). Tyrosine phosphorylation of the captured proteins is detected with an HRP-conjugated pan phospho-tyrosine antibody (Step 2) and then visualized using chemiluminescent detection reagents (Step 3). The signal produced is proportional to the amount phosphorylation in the bound analyte.

Why Use an Antibody Array to Detect Receptor Phosphorylation?

Determining the phosphorylation of multiple receptors in a single sample can be expensive, time consuming and can require specialized equipment. Performing multiple immunoprecipitations and Western blots requires time, labor, and reagents. The use of a multiplex antibody array to detect multiple phosphorylations in a single sample can be cost-effective and also save time and sample.

 
Kit Contents
  • 4 Array Membranes
  • 4-Well Multi-dish
  • Array Buffers
  • Lysis Buffer
  • Wash Buffer
  • Anti-Phospho-Tyrosine-HRP Detection Antibody
  • Chemiluminescent Detection Reagents
  • Transparency Overlay Template
  • Detailed Protocol

For a complete list of the kit contents and necessary materials, please see the Materials Provided/Other Supplies Required sections of the product datasheet.

Stability and Storage

Store the unopened kit at 2 °C to 8 °C. Do not use past kit expiration date.

 
Simultaneously detect the relative phosphorylation of these RTKs in a single sample
ALK/CD246 EphB4 MuSK
Axl EphB6 PDGF R alpha
DDR1 ErbB2 PDGF R beta
DDR2 ErbB3 c-Ret
Dtk ErbB4 ROR1
EGF R FGF R1 ROR2
EphA1 FGF R2 alpha Ryk
EphA2 FGF R3 SCF R/c-kit
EphA3 FGF R4 Tie-1
EphA4 Flt-3/Flk-2 Tie-2
EphA5 HGF R/c-MET TrkA
EphA6 IGF-I R TrkB
EphA7 Insulin R/CD220 TrkC
EphA10 M-CSF R VEGF R1/Flt-1
EphB1 Mer VEGF R2/KDR
EphB2 MSP R/Ron VEGF R3/Flt-4
EphB3    
 

Assays for Analytes represented in the Proteome Profiler Human Phospho-RTK Array Kit

 
Analyte Quantikine® ELISA Kits DuoSet® ELISA Development System DuoSet® IC ELISA Development Systems (Total) DuoSet® IC ELISA Development Systems (Phospho) Cell-based ELISA Kits
ALK/CD246          
Axl   DY154 DYC1643    
DDR1     DYC2396 DYC5859  
DDR2     DYC2538 DYC6170  
Dtk   DY859      
EGF R DEGFR0 DY231 DYC1854 DYC1095B  
EphA1     DYC638    
EphA2     DYC3035 DYC4056  
EphA3          
EphA4     DYC3038 DYC4057  
EphA5          
EphA6          
EphA7          
EphA10          
EphB1          
EphB2          
EphB3          
EphB4     DYC3038 DYC4057  
ErbB2   DY1129 DYC1129 DYC1768  
ErbB3   DY348 DYC234 DYC1769 KCB5677
ErbB4     DYC1133 DYC2115
ErbB6          
FGF R1       DYC5079  
FGF R2 alpha     DYC665 DYC684  
FGF R3     DYC766 DYC2719  
FGF R4     DYC685 DYC5516  
Flt-3/Flk     DYC912 DYC368  
HGF R/c-MET   DY358 DYC358 DYC2480  
IGF-I R   DY391 DYC305 DYC1770  
Insulin R/CD220     DYC1544 DYC2718  
M-CSF R   DY329 DYC329 DYC3268  
Mer   DY6488 DYC891 DYC2579  
MSP R/Ron     DYC691 DYC1947  
MuSK          
PDGF R alpha     DYC322 DYC2114  
Ret          
ROR1          
ROR2          
Ryk          
PDGF R beta     DYC385 DYC1767  
DYC3096  
SCF R/c-kit DSCR00 DY332 DYC332 DYC3527  
Tie-1   DY5907      
Tie-2 DTE200 DY5159   DCY2720  
TrkA     DYC175 DYC2578  
TrkB     DYC397 DYC688  
TrkC     DYC373    
VEGF R1/Flt-1 DVR100B DY321B   DYC4170  
VEGF R2/KDR DVR200 DY357 DYC1780 DYC1766  
VEGF R3/Flt-4   DY349 DYC3491 DYC2724  

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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Scientific Data

N/A Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line. View Larger

Detection of Human Receptor Tyrosine Kinase Phosphorylation in KATO-III Cell Line. KATO-III human gastric carcinoma cells were either untreated or treated with 100 ng/mL rhFGF acidic and 1 μg/mL heparin for 15 minutes. Cells for rhFGF acidic/Heparin treatment either received pre-treatment with the reversible FGF R and VEGF R inhibitor PD 173074 (Tocris, Catalog # 3044), or with the FGF R-specific tyrosine kinase inhibitor SU 5402 (Tocris, Catalog # 3300), or no pre-treatment.

N/A The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. View Larger

The Human Phospho-RTK Array is specific for ErbB2, ErbB3, and ErbB4 as shown by receptor competition. MDA-MB-453 human breast cancer cells were treated with 100 ng/mL of rhNRG1-beta1/HRG1-beta1 (R&D Systems, Catalog # 396-HB) for 5 minutes. 5 µg of rhErbB2 (R&D Systems, Catalog # 1129-ER), rhErbB3 (R&D Systems, Catalog # 348-RB), or rhErbB4 (R&D Systems, Catalog # 1131-ER) extracellular domains were added to 50 µg of lysate and analyzed using the Human Phospho-RTK Array. Competition of a particular ErbB receptor was observed only with the corresponding recombinant soluble receptor.

Citations for Proteome Profiler Human Phospho-RTK Array Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

274 Citations: Showing 1 - 10
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  1. Potential Utility of a 4th-Generation EGFR-TKI and Exploration of Resistance Mechanisms-An In Vitro Study
    Authors: Fukuda, S;Suda, K;Hamada, A;Oiki, H;Ohara, S;Ito, M;Soh, J;Mitsudomi, T;Tsutani, Y;
    Biomedicines  2024-06-25
  2. Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression
    Authors: Jang, HJ;Min, HY;Kang, YP;Boo, HJ;Kim, J;Ahn, JH;Oh, SH;Jung, JH;Park, CS;Park, JS;Kim, SY;Lee, HY;
    Nature communications  2024-06-08
  3. Targeting isoforms of RON kinase (MST1R) drives antitumor efficacy
    Authors: Kim, J;Koh, DI;Lee, M;Park, YS;Hong, SW;Shin, JS;Lee, MS;Kim, MH;Lee, JH;Jeong, J;Bae, S;Hong, JK;Jeong, HR;Ryu, YS;Kim, SM;Choi, M;Kim, H;Ryu, H;Hur, SC;Park, J;Hur, DY;Jin, DH;
    Cell death and differentiation  2023-11-06
  4. Immunization with a multi-antigen targeted DNA vaccine eliminates chemoresistant pancreatic cancer by disrupting tumor-stromal cell crosstalk
    Authors: Qin, H;Chen, J;Bouchekioua-Bouzaghou, K;Meng, YM;Griera, JB;Jiang, X;Kong, X;Wang, M;Xu, Q;Wong, PP;
    Journal of translational medicine  2023-10-09
  5. Efficacy of gilteritinib in comparison with alectinib for the treatment of ALK-rearranged non-small cell lung cancer
    Authors: Ando, C;Ichihara, E;Nishi, T;Morita, A;Hara, N;Takada, K;Nakasuka, T;Watanabe, H;Kano, H;Nishii, K;Makimoto, G;Kondo, T;Ninomiya, K;Fujii, M;Kubo, T;Ohashi, K;Matsuoka, KI;Hotta, K;Tabata, M;Maeda, Y;Kiura, K;
    Cancer science  2023-09-15
  6. EGFR inhibition overcomes resistance to FGFR4 inhibition and potentiates FGFR4 inhibitor therapy in hepatocellular carcinoma
    Authors: Shen, B;Shi, J;Zhu, Z;He, Z;Liu, S;Shi, W;Zhang, Y;Ying, H;Wang, J;Xu, R;Fang, F;Chang, HX;Chen, Z;Zhang, N;
    Molecular cancer therapeutics  2023-09-15
  7. IGF1R Contributes to Cell Proliferation in ALK-Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway
    Authors: Guan, J;Borenäs, M;Xiong, J;Lai, WY;Palmer, RH;Hallberg, B;
    Cancers  2023-08-25
  8. Epithelial cell adhesion molecule (EpCAM) regulates HGFR signaling to promote colon cancer progression and metastasis
    Authors: Lee, CC;Yu, CJ;Panda, SS;Chen, KC;Liang, KH;Huang, WC;Wang, YS;Ho, PC;Wu, HC;
    Journal of translational medicine  2023-08-05
  9. Pictilisib-Induced Resistance Is Mediated through FOXO1-Dependent Activation of Receptor Tyrosine Kinases in Mucinous Colorectal Adenocarcinoma Cells
    Authors: Kuracha, MR;Govindarajan, V;Loggie, BW;Tobi, M;McVicker, BL;
    International journal of molecular sciences  2023-08-02
  10. Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro
    Authors: Meng, M;Tan, J;Chen, H;Shi, Z;Kwan, HY;Su, T;
    Heliyon  2023-08-01
  11. ARL6IP5 Ameliorates alpha -Synuclein Burden by Inducing Autophagy via Preventing Ubiquitination and Degradation of ATG12
    Authors: Siddique, I;Kamble, K;Gupta, S;Solanki, K;Bhola, S;Ahsan, N;Gupta, S;
    International journal of molecular sciences  2023-06-22
  12. Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    Authors: Kim, S;Carvajal, R;Kim, M;Yang, HW;
    Cell reports  2023-05-29
  13. Radiation therapy attenuates lymphatic vessel repair by reducing VEGFR-3 signalling
    Authors: Pillay, V;Shukla, L;Herle, P;Maciburko, S;Bandara, N;Reid, I;Morgan, S;Yuan, Y;Luu, J;Cowley, KJ;Ramm, S;Simpson, KJ;Achen, MG;Stacker, SA;Shayan, R;Karnezis, T;
    Frontiers in pharmacology  2023-04-28
  14. Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities
    Authors: I Paassen, J Williams, C Ríos Arceo, F Ringnalda, KS Mercer, JL Buhl, N Moreno, A Federico, NE Franke, M Kranendonk, SA Upadhyaya, K Kerl, M van de Wet, H Clevers, M Kool, EW Hoving, MF Roussel, J Drost
    Oncogene, 2023-04-05;0(0):.  2023-04-05
  15. Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema
    Authors: JJ Park, K Oh, GW Lee, G Bang, JH Park, HB Kim, JY Kim, EY Shin, EG Kim
    Experimental & Molecular Medicine, 2023-04-03;0(0):.  2023-04-03
  16. Redundant Signaling as the Predominant mechanism for Resistance to Antibodies Targeting IGF-1R in Cells Derived from Childhood Sarcoma
    Authors: TJ Shacklefor, S Hariharan, AV Vaseva, K Alagoa, M Espinoza, HK Bid, F Li, H Zhong, DA Phelps, RD Roberts, H Cam, CA London, DC Guttridge, Y Chen, M Rao, Y Shiio, PJ Houghton
    Molecular Cancer Therapeutics, 2023-04-03;0(0):.  2023-04-03
  17. Integrated CRISPR screening and drug profiling identifies combination opportunities for EGFR, ALK, and BRAF/MEK inhibitors
    Authors: R Tiedt, FJ King, C Stamm, MJ Niederst, S Delach, S Zumstein-M, J Meltzer, IJ Mulford, E Labrot, BS Engstler, S Baltschuka, G Kerr, J Golji, D Wyss, C Schnell, E Ainscow, JA Engelman, WR Sellers, J Barretina, G Caponigro, DG Porta
    Cell Reports, 2023-03-23;42(4):112297.  2023-03-23
  18. IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis
    Authors: W Lin, R Niu, SM Park, Y Zou, SS Kim, X Xia, S Xing, Q Yang, X Sun, Z Yuan, S Zhou, D Zhang, HJ Kwon, S Park, C Il Kim, H Koo, Y Liu, H Wu, M Zheng, H Yoo, B Shi, JB Park, J Yin
    Nature Communications, 2023-03-22;14(1):1578.  2023-03-22
  19. The 5-lipoxygenase/cyclooxygenase-2 (5-LOX/COX-2) cross-over metabolite, hemiketal E2, enhances VEGFR2 activation and promotes angiogenesis
    Authors: F Nakashima, J Giménez-Ba, P Luis, S Presley, R Boer, M Chiusa, T Shibata, G Sulikowski, A Pozzi, C Schneider
    The Journal of Biological Chemistry, 2023-02-21;0(0):103050.  2023-02-21
  20. Stellettin B Induces Cell Death in Bladder Cancer Via Activating the Autophagy/DAPK2/Apoptosis Signaling Cascade
    Authors: CH Chang, BJ Lin, CH Chen, NL Nguyen, TH Hsieh, JH Su, MC Chen
    Marine Drugs, 2023-01-21;21(2):.  2023-01-21
  21. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
    Authors: ZS Lin, CC Chung, YC Liu, CH Chang, HC Liu, YY Liang, TL Huang, TM Chen, CH Lee, CH Tang, MC Hung, YH Chen
    Elife, 2023-01-09;12(0):.  2023-01-09
  22. Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung Cancer
    Authors: Lee, K;Lai, T;Lee, W;Chen, Y;Ho, K;Hung, W;Yang, Y;Chan, M;Hsieh, F;Chung, C;Chang, J;Chien, M;
    Cancers  2023-01-01
  23. Targeting Ras signaling excitability in cancer cells through combined inhibition of FAK and PI3K
    Authors: Chen, C;Wang, S;Yang, J;Huang, C;
    bioRxiv  2023-01-01
  24. Particulate matter promotes cancer metastasis through increased HBEGF expression in macrophages
    Authors: SH Park, SJ Yoon, S Choi, J Jung, JY Park, YH Park, J Seo, J Lee, MS Lee, SJ Lee, MY Son, YL Cho, JS Kim, HJ Lee, J Jeong, DS Kim, YJ Park
    Experimental & Molecular Medicine, 2022-11-09;0(0):.  2022-11-09
  25. Glycosyltransferases EXTL2 and EXTL3 cellular balance dictates Heparan Sulfate biosynthesis and shapes gastric cancer cell motility and invasion
    Authors: C Marques, J Poças, C Gomes, I Faria-Ramo, CA Reis, RR Vivès, A Magalhães
    The Journal of Biological Chemistry, 2022-09-28;0(0):102546.  2022-09-28
  26. Genomic and biological study of fusion genes as resistance mechanisms to EGFR inhibitors
    Authors: Y Kobayashi, GR Oxnard, EF Cohen, NR Mahadevan, JV Alessi, YP Hung, AA Bertram, DE Heppner, MF Ribeiro, KP Sacardo, R Saddi, MP Macedo, RB Blasco, J Li, KJ Kurppa, T Nguyen, E Voligny, G Ananda, R Chiarle, A Katz, MY Tolstoruko, LM Sholl, PA Jänne
    Nature Communications, 2022-09-24;13(1):5614.  2022-09-24
  27. Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells
    Authors: M Krchniakov, S Paukovceko, P Chlapek, J Neradil, J Skoda, R Veselska
    Frontiers in Pharmacology, 2022-09-07;13(0):976955.  2022-09-07
  28. Regulation of CCL2 by EZH2 affects tumor-associated macrophages polarization and infiltration in breast cancer
    Authors: YF Wang, L Yu, ZL Hu, YF Fang, YY Shen, MF Song, Y Chen
    Cell Death & Disease, 2022-08-29;13(8):748.  2022-08-29
  29. Suppression of heparan sulfation re-sensitizes YAP1-driven melanoma to MAPK pathway inhibitors
    Authors: SM Dieter, D Lovecchio, A Pataskar, MK Zowada, PR Körner, A Khalizieva, O van Tellin, D Jäger, H Glimm, R Agami
    Oncogene, 2022-07-07;0(0):.  2022-07-07
  30. KRASG12C-independent feedback activation of wild-type RAS constrains KRASG12C inhibitor efficacy
    Authors: MB Ryan, O Coker, A Sorokin, K Fella, H Barnes, E Wong, P Kanikarla, F Gao, Y Zhang, L Zhou, S Kopetz, RB Corcoran
    Cell Reports, 2022-06-21;39(12):110993.  2022-06-21
  31. EGFR inhibition reverses resistance to lenvatinib in hepatocellular carcinoma cells
    Authors: X He, Y Hikiba, Y Suzuki, Y Nakamori, Y Kanemaru, M Sugimori, T Sato, A Nozaki, M Chuma, S Maeda
    Scientific Reports, 2022-05-14;12(1):8007.  2022-05-14
  32. Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
    Authors: AJ Weickhardt, DK Lau, M Hodgson-Ga, A Lavis, LJ Jenkins, N Vukelic, P Ioannidis, IY Luk, JM Mariadason
    BMC Cancer, 2022-05-02;22(1):478.  2022-05-02
  33. EGFR/MET promotes hepatocellular carcinoma metastasis by stabilizing tumor cells and resisting to RTKs inhibitors in circulating tumor microemboli
    Authors: S Song, Z Yu, Y You, C Liu, X Xie, H Lv, F Xiao, Q Zhu, C Qin
    Cell Death & Disease, 2022-04-15;13(4):351.  2022-04-15
  34. Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion
    Authors: C Gaiteiro, J Soares, M Relvas-San, A Peixoto, D Ferreira, P Paulo, A Brandão, E Fernandes, R Azevedo, C Palmeira, R Freitas, A Miranda, H Osório, J Prieto, L Lima, AMN Silva, LL Santos, JA Ferreira
    Theranostics, 2022-03-28;12(7):3150-3177.  2022-03-28
  35. Different HSP90 Inhibitors Exert Divergent Effect on Myxoid Liposarcoma In Vitro and In Vivo
    Authors: C Vannas, L Andersson, S Dolatabadi, P Ranji, M Lindén, E Jonasson, A Ståhlberg, H Fagman, P Åman
    Biomedicines, 2022-03-07;10(3):.  2022-03-07
  36. Stem Cells From Human Exfoliated Deciduous Teeth-Conditioned Medium (SHED-CM) is a Promising Treatment for Amyotrophic Lateral Sclerosis
    Authors: T Ueda, T Ito, M Inden, H Kurita, A Yamamoto, I Hozumi
    Frontiers in Pharmacology, 2022-02-03;13(0):805379.  2022-02-03
  37. Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
    Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
    Disease Models & Mechanisms, 2022-01-27;0(0):.  2022-01-27
  38. Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
    Authors: L Scherschin, M Prem, I Kremenetsk, I Tinhofer, P Vajkoczy, AG Karbe, JS Onken
    International Journal of Molecular Sciences, 2022-01-17;23(2):.  2022-01-17
  39. Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor
    Authors: J Zhi, J Yi, X Hou, W Wang, W Yang, L Hu, J Huang, S Guo, X Ruan, M Gao, X Zheng
    American journal of cancer research, 2022-01-15;12(1):247-264.  2022-01-15
  40. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma
    Authors: H Patel, R Mishra, N Yacoub, S Alanazi, MK Kilroy, JT Garrett
    Cancers, 2021-11-22;13(22):.  2021-11-22
  41. Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways
    Authors: TA Mannsåker, T Hoang, SN Aasen, OV Bjørnstad, H Parajuli, T Sundstrøm, FA Thorsen
    International Journal of Molecular Sciences, 2021-11-14;22(22):.  2021-11-14
  42. ISL1 promotes enzalutamide resistance in castration-resistant prostate cancer (CRPC) through epithelial to mesenchymal transition (EMT)
    Authors: JD Choi, TJ Kim, BC Jeong, HG Jeon, SS Jeon, MY Kang, SY Yeom, SI Seo
    Scientific Reports, 2021-11-09;11(1):21984.  2021-11-09
  43. Three newly established immortalized mesothelial cell lines exhibit morphological phenotypes corresponding to malignant mesothelioma epithelioid, intermediate, and sarcomatoid types, respectively
    Authors: T Sato, H Nakanishi, K Akao, M Okuda, S Mukai, T Kiyono, Y Sekido
    Cancer Cell International, 2021-10-18;21(1):546.  2021-10-18
  44. Characterization of receptor tyrosine kinase activation and biological activity of toceranib phosphate in canine urothelial carcinoma cell lines
    Authors: DI Korec, DS Louke, JT Breitbach, JA Geisler, BD Husbands, JM Fenger
    Bmc Veterinary Research, 2021-10-02;17(1):320.  2021-10-02
  45. Oral submucous fibrosis stimulates invasion and epithelial-mesenchymal transition in oral squamous cell carcinoma by activating MMP-2 and IGF-IR
    Authors: PN Chen, CW Lin, SF Yang, YC Chang
    Journal of Cellular and Molecular Medicine, 2021-09-15;0(0):.  2021-09-15
  46. NOTCH1 signaling promotes protein stability of HER3 through the AKT pathway in squamous cell carcinoma of head and neck
    Authors: YP Wang, IJ Liu, KC Chen, HC Wu
    Oncogenesis, 2021-08-31;10(8):59.  2021-08-31
  47. Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression
    Authors: SJ Oh, KH Noh, KH Song, TW Kim
    International Journal of Molecular Sciences, 2021-08-17;22(16):.  2021-08-17
  48. Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration
    Authors: P Ebner-Peki, L Krisch, M Wolf, S Hochmann, A Hoog, B Vári, K Muigg, R Poupardin, C Scharler, S Schmidhube, E Russe, H Stachelsch, A Schneeberg, K Schallmose, D Strunk
    Theranostics, 2021-07-25;11(17):8430-8447.  2021-07-25
  49. Histone deacetylase inhibitor panobinostat induces antitumor activity in epithelioid sarcoma and rhabdoid tumor by growth factor receptor modulation
    Authors: AC Harttrampf, MEM da Costa, A Renoult, E Daudigeos-, B Geoerger
    BMC Cancer, 2021-07-20;21(1):833.  2021-07-20
  50. New Target for Precision Medicine Treatment of Giant-Cell Tumor of Bone: Sunitinib Is Effective in the Treatment of Neoplastic Stromal Cells with Activated PDGFRbeta Signaling
    Authors: M Mahdal, J Neradil, P Mudry, S Paukovceko, I Staniczkov, J Urban, P Macsek, L Pazourek, T Tomas, R Veselska
    Cancers, 2021-07-15;13(14):.  2021-07-15
  51. Triple therapy with osimertinib, bevacizumab and cetuximab in EGFR-mutant lung cancer with HIF-1alpha/TGF-alpha expression
    Authors: K Nishii, K Ohashi, H Watanabe, G Makimoto, T Nakasuka, H Higo, K Ninomiya, Y Kato, T Kubo, K Rai, E Ichihara, K Hotta, M Tabata, Y Maeda, K Kiura
    Oncology Letters, 2021-07-07;22(3):639.  2021-07-07
  52. Identification of Phospho-Tyrosine Targets as a Strategy for the Treatment of Esophageal Adenocarcinoma Cells
    Authors: J Lee, R Chen, T Mohanakuma, R Bremner, S Mittal, TP Fleming
    OncoTargets and Therapy, 2021-06-21;14(0):3813-3820.  2021-06-21
  53. Identification of Nucleolin as a Novel AEG-1-Interacting Protein in Breast Cancer via Interactome Profiling
    Authors: SJ Lee, KM Choi, G Bang, SG Park, EB Kim, JW Choi, YH Chung, J Kim, SG Lee, E Kim, JY Kim
    Cancers, 2021-06-07;13(11):.  2021-06-07
  54. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation
    Authors: HH Lee, YN Wang, WH Yang, W Xia, Y Wei, LC Chan, YH Wang, Z Jiang, S Xu, J Yao, Y Qiu, YH Hsu, WL Hwang, M Yan, JH Cha, JL Hsu, J Shen, Y Ye, X Wu, MF Hou, LM Tseng, SC Wang, MR Pan, CH Yang, YL Wang, H Yamaguchi, D Pang, GN Hortobagyi, D Yu, MC Hung
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  55. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells
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  207. Fibroblast Growth Factor Receptor 3 (FGFR3) Associated with the CD20 Antigen Regulates the Rituximab-induced Proliferation Inhibition in B-cell Lymphoma Cells.
    Authors: Kotani N, Ishiura Y, Yamashita R, Ohnishi T, Honke K
    J Biol Chem, 2012-08-29;287(44):37109-18.  2012-08-29
  208. Identifying and targeting ROS1 gene fusions in non-small cell lung cancer.
    Clin. Cancer Res., 2012-08-23;18(17):4570-9.  2012-08-23
  209. Prostaglandin E(2) induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.
    J. Immunol., 2012-07-27;189(5):2563-73.  2012-07-27
  210. PDGF receptor alpha is an alternative mediator of rapamycin-induced Akt activation: implications for combination targeted therapy of synovial sarcoma.
    Authors: Ho A, Vasudeva S, Lae M, Saito T, Barbashina V, Antonescu C, Ladanyi M, Schwartz G
    Cancer Res, 2012-07-10;72(17):4515-25.  2012-07-10
  211. Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer.
    Authors: Duncan J, Whittle M, Nakamura K, Abell A, Midland A, Zawistowski J, Johnson N, Granger D, Jordan N, Darr D, Usary J, Kuan P, Smalley D, Major B, He X, Hoadley K, Zhou B, Sharpless N, Perou C, Kim W, Gomez S, Chen X, Jin J, Frye S, Earp H, Graves L, Johnson G
    Cell, 2012-04-13;149(2):307-21.  2012-04-13
  212. Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells.
    Authors: Oliveras-Ferraros C, Cufi S, Queralt B, Vazquez-Martin A, Martin-Castillo B, de Llorens R, Bosch-Barrera J, Brunet J, Menendez JA
    Br. J. Cancer, 2012-04-10;106(8):1406-14.  2012-04-10
  213. Phosphoproteomics identifies driver tyrosine kinases in sarcoma cell lines and tumors.
    Authors: Bai Y, Li J, Fang B, Edwards A, Zhang G, Bui M, Eschrich S, Altiok S, Koomen J, Haura E
    Cancer Res, 2012-03-29;72(10):2501-11.  2012-03-29
  214. Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition.
    Authors: Gowrishankar K, Snoyman S, Pupo GM, Becker TM, Kefford RF, Rizos H
    J. Invest. Dermatol., 2012-03-22;132(7):1850-9.  2012-03-22
  215. Inhibition of platelet-derived growth factor receptor signaling regulates Oct4 and Nanog expression, cell shape, and mesenchymal stem cell potency.
    Authors: Ball SG, Shuttleworth A, Kielty CM
    Stem Cells, 2012-03-01;30(3):548-60.  2012-03-01
  216. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).
    Authors: Poulikakos PI, Persaud Y, Janakiraman M
    Nature, 2011-11-23;480(7377):387-90.  2011-11-23
  217. MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway.
    Authors: Lorenzon E, Colladel R, Andreuzzi E, Marastoni S, Todaro F, Schiappacassi M, Ligresti G, Colombatti A, Mongiat M
    Oncogene, 2011-10-24;31(26):3136-47.  2011-10-24
  218. Glucose and collagen regulate human platelet activity through aldose reductase induction of thromboxane.
    Authors: Tang WH, Stitham J, Gleim S, Di Febbo C, Porreca E, Fava C, Tacconelli S, Capone M, Evangelista V, Levantesi G, Wen L, Martin K, Minuz P, Rade J, Patrignani P, Hwa J
    J. Clin. Invest., 2011-10-17;121(11):4462-76.  2011-10-17
  219. Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation.
    Authors: Jiao Y, Ou W, Meng F
    Mol. Cancer, 2011-09-30;10(0):125.  2011-09-30
  220. Differential roles of trans-phosphorylated EGFR, HER2, HER3, and RET as heterodimerisation partners of MET in lung cancer with MET amplification.
    Authors: Tanizaki J, Okamoto I, Sakai K
    Br. J. Cancer, 2011-08-16;105(6):807-13.  2011-08-16
  221. EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy.
    Authors: Lupberger J, Zeisel MB, Xiao F, Thumann C, Fofana I, Zona L, Davis C, Mee CJ, Turek M, Gorke S, Royer C, Fischer B, Zahid MN, Lavillette D, Fresquet J, Cosset FL, Rothenberg SM, Pietschmann T, Patel AH, Pessaux P, Doffoel M, Raffelsberger W, Poch O, McKeating JA, Brino L, Baumert TF
    Nat. Med., 2011-04-24;17(5):589-95.  2011-04-24
  222. Sesamin induces autophagy in colon cancer cells by reducing tyrosine phosphorylation of EphA1 and EphB2.
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    Int. J. Oncol., 2011-04-18;39(1):33-40.  2011-04-18
  223. The MARCH family E3 ubiquitin ligase K5 alters monocyte metabolism and proliferation through receptor tyrosine kinase modulation.
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  224. Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
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  225. Tyrosine phosphorylation profiling in FGF-2 stimulated human embryonic stem cells.
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  226. Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion.
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  227. Feedback upregulation of HER3 (ErbB3) expression and activity attenuates antitumor effect of PI3K inhibitors.
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  228. 18FDG-PET Predicts Pharmacodynamic Response to OSI-906, a Dual IGF-1R/IR Inhibitor, in Preclinical Mouse Models of Lung Cancer.
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  229. Targeted inhibition of multiple receptor tyrosine kinases in mesothelioma.
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  230. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K.
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  231. A Variant in a MicroRNA complementary site in the 3' UTR of the KIT oncogene increases risk of acral melanoma.
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  232. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation.
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  233. Somatic cell plasticity and Niemann-Pick type C2 protein: fibroblast activation.
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  234. Reciprocal and complementary role of MET amplification and EGFR T790M mutation in acquired resistance to kinase inhibitors in lung cancer.
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  235. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
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  236. Pathway-focused proteomic signatures in HER2-overexpressing breast cancer with a basal-like phenotype: new insights into de novo resistance to trastuzumab (Herceptin).
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  237. Coactivated platelet-derived growth factor receptor alpha and epidermal growth factor receptor are potential therapeutic targets in intimal sarcoma.
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    Cancer Res., 2010-08-04;70(18):7304-14.  2010-08-04
  238. Somatic cell plasticity and Niemann-pick type C2 protein: adipocyte differentiation and function.
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    J. Biol. Chem., 2010-07-22;285(39):30347-54.  2010-07-22
  239. Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch.
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    Blood, 2010-07-06;116(16):2984-93.  2010-07-06
  240. Sunitinib in metastatic thymic carcinomas: laboratory findings and initial clinical experience.
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    Br. J. Cancer, 2010-06-22;103(2):196-200.  2010-06-22
  241. Functional mapping of receptor tyrosine kinases in myxoid liposarcoma.
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    Clin. Cancer Res., 2010-06-03;16(14):3581-93.  2010-06-03
  242. Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response.
    Authors: Stacchiotti S, Negri T, Palassini E, Conca E, Gronchi A, Morosi C, Messina A, Pastorino U, Pierotti MA, Casali PG, Pilotti S
    Mol. Cancer Ther., 2010-05-01;9(5):1286-97.  2010-05-01
  243. Inhibition of the insulin-like growth factor I receptor by epigallocatechin gallate blocks proliferation and induces the death of Ewing tumor cells.
    Authors: Kang HG, Jenabi JM, Liu XF, Reynolds CP, Triche TJ, Sorensen PH
    Mol. Cancer Ther., 2010-04-27;9(5):1396-407.  2010-04-27
  244. VEGF-A promotes lymphoma tumour growth by activation of STAT proteins and inhibition of p27(KIP1) via paracrine mechanisms.
    Authors: Roorda BD, Ter Elst A, Scherpen FJ, Meeuwsen-de Boer TG, Kamps WA, de Bont ES
    Eur. J. Cancer, 2010-01-22;46(5):974-82.  2010-01-22
  245. Human cancers converge at the HIF-2alpha oncogenic axis.
    Authors: Franovic A, Holterman CE, Payette J, Lee S
    Proc. Natl. Acad. Sci. U.S.A., 2009-12-02;106(50):21306-11.  2009-12-02
  246. Abnormal myocardial insulin signalling in type 2 diabetes and left-ventricular dysfunction.
    Authors: Cook SA, Varela-Carver A, Mongillo M
    Eur. Heart J., 2009-10-01;31(1):100-11.  2009-10-01
  247. Combination of EGFR and MEK1/2 inhibitor shows synergistic effects by suppressing EGFR/HER3-dependent AKT activation in human gastric cancer cells.
    Authors: Yoon YK, Kim HP, Han SW, Hur HS, Oh do Y, Im SA, Bang YJ, Kim TY
    Mol. Cancer Ther., 2009-09-15;8(9):2526-36.  2009-09-15
  248. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.
    Authors: Bax DA, Gaspar N, Little SE, Marshall L, Perryman L, Regairaz M, Viana-Pereira M, Vuononvirta R, Sharp SY, Reis-Filho JS, Stavale JN, Al-Sarraj S, Reis RM, Vassal G, Pearson AD, Hargrave D, Ellison DW, Workman P, Jones C
    Clin. Cancer Res., 2009-09-08;15(18):5753-61.  2009-09-08
  249. A complex role for FGF-2 in self-renewal, survival, and adhesion of human embryonic stem cells.
    Authors: Eiselleova L, Matulka K, Kriz V, Kunova M, Schmidtova Z, Neradil J, Tichy B, Dvorakova D, Pospisilova S, Hampl A, Dvorak P
    Stem Cells, 2009-08-01;27(8):1847-57.  2009-08-01
  250. Decorin is a novel antagonistic ligand of the Met receptor.
    Authors: Goldoni S, Humphries A, Nystrom A, Sattar S, Owens RT, McQuillan DJ, Ireton K, Iozzo RV
    J. Cell Biol., 2009-05-11;185(4):743-54.  2009-05-11
  251. Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells.
    Authors: Kawaguchi K, Murakami H, Taniguchi T, Fujii M, Kawata S, Fukui T, Kondo Y, Osada H, Usami N, Yokoi K, Ueda Y, Yatabe Y, Ito M, Horio Y, Hida T, Sekido Y
    Carcinogenesis, 2009-04-20;30(7):1097-105.  2009-04-20
  252. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
    Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
    Cancer Res., 2009-03-24;69(7):2996-3003.  2009-03-24
  253. Transactivation of RON receptor tyrosine kinase by interaction with PDGF receptor beta during steady-state growth of human mesangial cells.
    Authors: Kobayashi T, Furukawa Y, Kikuchi J, Ito C, Miyata Y, Muto S, Tanaka A, Kusano E
    Kidney Int., 2009-02-25;75(11):1173-83.  2009-02-25
  254. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells.
    Authors: Agarwal S, Zerillo C, Kolmakova J, Christensen JG, Harris LN, Rimm DL, Digiovanna MP, Stern DF
    Br. J. Cancer, 2009-02-24;100(6):941-9.  2009-02-24
  255. A redox-silent analogue of tocotrienol acts as a potential cytotoxic agent against human mesothelioma cells.
    Authors: Kashiwagi K, Virgona N, Harada K, Kido W, Yano Y, Ando A, Hagiwara K, Yano T
    Life Sci., 2009-02-14;84(19):650-6.  2009-02-14
  256. Response to sunitinib malate in advanced alveolar soft part sarcoma.
    Authors: Stacchiotti S, Tamborini E, Marrari A, Brich S, Rota SA, Orsenigo M, Crippa F, Morosi C, Gronchi A, Pierotti MA, Casali PG, Pilotti S
    Clin. Cancer Res., 2009-02-01;15(3):1096-104.  2009-02-01
  257. Stratification of pediatric ALL by in vitro cellular responses to DNA double-strand breaks provides insight into the molecular mechanisms underlying clinical response.
    Authors: Marston E, Weston V, Jesson J, Maina E, McConville C, Agathanggelou A, Skowronska A, Mapp K, Sameith K, Powell JE, Lawson S, Kearns P, Falciani F, Taylor M, Stankovic T
    Blood, 2008-10-21;113(1):117-26.  2008-10-21
  258. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors.
    Authors: Buck E, Eyzaguirre A, Rosenfeld-Franklin M, Thomson S, Mulvihill M, Barr S, Brown E, O'Connor M, Yao Y, Pachter J, Miglarese M, Epstein D, Iwata KK, Haley JD, Gibson NW, Ji QS
    Cancer Res., 2008-10-15;68(20):8322-32.  2008-10-15
  259. Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.
    Authors: Shimamura T, Li D, Ji H, Haringsma HJ, Liniker E, Borgman CL, Lowell AM, Minami Y, McNamara K, Perera SA, Zaghlul S, Thomas RK, Greulich H, Kobayashi S, Chirieac LR, Padera RF, Kubo S, Takahashi M, Tenen DG, Meyerson M, Wong KK, Shapiro GI
    Cancer Res., 2008-07-15;68(14):5827-38.  2008-07-15
  260. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer.
    Authors: Koivunen JP, Mermel C, Zejnullahu K, Murphy C, Lifshits E, Holmes AJ, Choi HG, Kim J, Chiang D, Thomas R, Lee J, Richards WG, Sugarbaker DJ, Ducko C, Lindeman N, Marcoux JP, Engelman JA, Gray NS, Lee C, Meyerson M, Janne PA
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  261. Molecular characterization of pediatric gastrointestinal stromal tumors.
    Authors: Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P, Antonescu CR
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  263. Differential expression of receptor tyrosine kinases (RTKs) and IGF-I pathway activation in human uterine leiomyomas.
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  264. FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival.
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FAQs

  1. What are the phosphorylation site(s) of the 49 different tyrosine residues on the RTKs?

    • This kit uses a pan anti-phospho-tyrosine antibody as the detection antibody, which means it is capable of detecting phosphorylation at any available tyrosine. It is not designed to be specific for one phosphorylation site on each molecule. For instance, PDGF R alpha has multiple sites of tyrosine phosphorylation (see the “PTM/Processing” section of http://www.uniprot.org/uniprot/P16234 for a list of the currently identified sites). 

  2. Can the Human Phospho-RTK Array be used for measuring the relative levels of total RTKs present in a sample?

    • No. Although the array kit uses capture antibodies that recognize both phosphorylated and unphosphorylated RTKs, the detection antibody is a pan anti-phospho-tyrosine antibody which only detects phosphorylated tyrosines on activated RTKs.

  3. To confirm positive signal for an RTK by IP-Western blot, are the capture antibodies from the Human Phospho-RTK Array Kit offered separately?

    • The identities of the capture antibodies on the Human Phospho-RTK Array are considered proprietary. However, to help investigators confirm their array results, Bio-Techne offers antibodies for each RTK detectable in the array kit. These antibodies are validated for Western blot and can be found in our catalog. A pan anti-phospho-tyrosine-HRP detection antibody is also available (Catalog # HAM1676).

  4. Are the capture antibodies from the Human Phospho-RTK Array Kit offered serparately to allow confirmation of positive signal by other methods?

    • The identities of the capture antibodies in the Human Phospho-RTK Array are considered proprietary. It can be challenging to directly compare Western Blot results of the linearized and reduced protein to Array detection of the native form. In ELISA, the protein will also be in the native form. ELISA kits are offered for many of the analytes targeted by the Array. These options are listed in a table on the product webpage.

View all Proteome Profiler Antibody Array FAQs
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Proteome Profiler Human Phospho-RTK Array Kit
By Adam Guess on 10/20/2017
Proteome Profiler Human Phospho-RTK Array Kit ARY001B