Prostaglandin E₂

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Prediction of DNA Repair Inhibitor Response in Short Term Patient-Derived Ovarian Cancer Organoids
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   Cancer Discov, 2018;0(0):.
2. Cardiosphere-derived cells suppress allogeneic lymphocytes by production of PGE2 acting via the EP4 receptor
   LC Dutton, J Dudhia, B Catchpole, H Hodgkiss-G, D Werling, DJ Connolly
   Sci Rep, 2018;8(1):13351.
3. Autophagy gene ATG7 regulates ultraviolet radiation-induced inflammation and skin tumorigenesis
   L Qiang, A Sample, CR Shea, K Soltani, KF Macleod, YY He
   Autophagy, 2017;0(0):0.
4. IgE receptor-mediated mast-cell renin release.
   Aldi S, Robador P, Tomita K, Di Lorenzo A, Levi R
   Am J Pathol, 2014;184(2):376-81.
5. Patient derived organoids to model rare prostate cancer phenotypes
   L Puca, R Bareja, D Prandi, R Shaw, M Benelli, WR Karthaus, J Hess, M Sigouros, A Donoghue, M Kossai, D Gao, J Cyrta, V Sailer, A Vosoughi, C Pauli, Y Churakova, C Cheung, LD Deonarine, TJ McNary, R Rosati, ST Tagawa, DM Nanus, JM Mosquera, CL Sawyers, Y Chen, G Inghirami, RA Rao, C Grandori, O Elemento, A Sboner, F Demichelis, MA Rubin, H Beltran
   Nat Commun, 2018;9(1):2404.
6. Classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes.
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   Pharmacol.Rev., 1994;46:205
7. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis.
   North et al.
   Nature., 2007;447:1007
8. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation.
   Hata and Breyer
   Pharm.Ther., 2004;103:147
9. Identification of multipotent luminal progenitor cells in human prostate organoid cultures.
   Karthaus et al.
   Cell, 2014;159:163
10. SnapShot: Growing Organoids from Stem Cells.
    Sato et al.
    Cell, 2015;161:1700
11. Prostaglandin E₂ increases lentiviral vector transduction efficiency of adult human hematopoietic stem and progenitor cells.
    Heffner et al.
    Mol.Ther, 2018;26:320
12. New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses
    A Gutjahr, L Papagno, F Vernejoul, T Lioux, F Jospin, B Chanut, E Perouzel, N Rochereau, V Appay, B Verrier, S Paul
    EBioMedicine, 2020;58(0):102922.
13. RSPO3 is important for trabecular bone and fracture risk in mice and humans
    KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson
    Nature Communications, 2021;12(1):4923.
14. Ewing Sarcoma-Derived Extracellular Vesicles Impair Dendritic Cell Maturation and Function
    H Gassmann, K Schneider, V Evdokimova, P Ruzanov, SJ Schober, B Xue, K von Heykin, M Thiede, GHS Richter, MW Pfaffl, E Noessner, LD Stein, PH Sorensen, SEG Burdach, U Thiel
    Cells, 2021;10(8):.

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