ProINDY
Chemical Name: (1Z)-1-(5-Acetyloxy3-ethyl-2(3H)-benzothiazolylidene)-2-propanone
Purity: ≥98%
Biological Activity
ProINDY is a DYRK1A/B inhibitor; prodrug form of INDY (Cat. No. 4997). Cell permeable. Inhibits phosphorylation of tau protein and rescues repressed calcineurin/NFAT signaling. Recovers Xenopus embryos from head malformation induced by DYRK1A overexpression in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A.
Ogawa et al.
Nat.Commun., 2010;1:86
Product Datasheets
Citations for ProINDY
The citations listed below are publications that use Tocris products. Selected citations for ProINDY include:
2 Citations: Showing 1 - 2
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A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibition.
Authors: Kim Et al.
Dis Model Mech 2016;9:839
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Stable Phenotypic Changes of the Host T Cells Are Essential to the Long-Term Stability of Latent HIV-1 Infection.
Authors: Seu Et al.
Sci Rep 2015;89:6656
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