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preQ1-alkyne

Catalog #: 7806 Datasheet
Catalog # Availability Size / Price Qty
7806/10
preQ1-alkyne | CAS No. 2771096-76-3 | CRISPR Reagents
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Description: preQ1 with alkyne handle for click chemistry

Chemical Name: N-[6-[[(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]amino]hexyl]-3-(2-propyn-1-yloxy)propanamide

Purity: ≥95%

Product Details
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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

preQ1-alkyne is a modified analog of the natural substrate prequeosine1 (preQ1). It contains alkyne handle that enables users to attach additional groups to preQ1 via Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It can be used to generate photoactivatable probes that can control CRISPR gene editing via the RNA-TAG method.

Other RNA-TAG toolbox compounds include preQ1-biotin (Cat. No. 7804)

Plasmids for expression of the E.coli TGT enzyme (#138201) and for cloning an RNA of interest into a vector containing the recognition motif at the 3' end (#138209) are available from Addgene.

Technical Data

M.Wt:
388.47
Formula:
C19H28N6O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2771096-76-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from The Regents of the University of California.

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