Pregnenolone sulfate sodium salt

Biological Activity

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular Ca²⁺ upon NMDA receptor-mediated synaptic activity (EC₅₀ ~ 2 pM) and potentiates NMDA responses. Inhibitor at GABA_A receptors (IC₅₀ values are 0.4 to >300 μM, depending on specific subunit conformation). Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Neuroactive steroids and human recombinant rho1 GABA_C receptors.
   Li et al.
   J.Pharmacol.Exp.Ther., 2007;323:236
2. Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels.
   Majeed et al.
   Br.J.Pharmacol., 2010;161:430
3. A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2⁺ signaling and CREB activation.
   Smith et al.
   Mol.Pharmacol., 2014;86:390
4. Probing GABA_A receptors with inhibitory neurosteroids.
   Seljeset et al.
   Neuropharmacology, 2018;136:23

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