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Prazosin hydrochloride

Catalog #: 0623
12 Citations Datasheet
Catalog # Availability Size / Price Qty
0623/100
Prazosin hydrochloride | CAS No. 19237-84-4 | Adrenergic alpha-1 Receptor Antagonists
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Description: α1 and α2B antagonist; also MT3 antagonist

Chemical Name: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride

Purity: ≥99%

Product Details
Citations (12)
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Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Prazosin hydrochloride is an α1 and α2B-adrenoceptor antagonist. Also a potent antagonist at the melatonin MT3 receptor (Ki = 10.2 nM). In prostate cancer cells, Prazosin induces DNA damage stress, Cdk1 inactivation, G2 checkpoint arrest and apoptosis. In mice bearing prostate cancer xenografts, oral administration of Prazosin reduces tumor mass.

Technical Data

M.Wt:
419.87
Formula:
C19H21N5O4.HCl
Solubility:
Soluble to 25 mM in DMSO and to 5 mM in ethanol
Purity:
≥99%
Storage:
Store at RT
CAS No:
19237-84-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Neuroendocrine Modulation of IL-27 in Macrophages
    J Roewe, M Higer, DR Riehl, A Gericke, MP Radsak, M Bosmann
    J. Immunol., 2017;0(0):.
  3. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats.
    Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, Morton G, Schwartz M, Baskin D, Appleyard S, Blevins J
    Endocrinology, 2014;155(8):2845-57.
  4. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  5. Characterisation of 2-[125I]iodomelatonin binding sites in syrian hamster peripheral organs.
    Paul et al.
    J.Pharmacol.Exp.Ther., 1999;290:334
  6. Prazosin inhibits MK-801-induced hyperlocomotion and DA release in the nucleus accumbens.
    Mathe et al.
    Eur.J.Pharmacol., 1996;309:1
  7. Pharmacological characterization of melatonin binding sites in Syrian hamster hypothalamus.
    Pickering and Niles
    Eur.J.Pharmacol., 1990;175:71
  8. Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle.
    Lin et al.
    Neoplasia, 2007;9:830

Product Datasheets

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Citations for Prazosin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Prazosin hydrochloride include:

12 Citations: Showing 1 - 10

  1. The anti-hypertensive drug pra. inhibits glioblastoma growth via the PKCδ-dependent inhibition of the AKT pathway.
    Authors: Kahn Et al.
    EMBO Mol Med  2016;8:511
  2. Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channels.
    Authors: Delaney and Crane
    Sci Rep  2016;6:19255
  3. Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.
    Authors: Skelly and Weiner
    Brain Behav  2014;4:468
  4. Dual effects of 5-HT(1a) receptor activation on breathing in neonatal mice.
    Authors: Corcoran Et al.
    Pain  2014;34:51
  5. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury.
    Authors: Hughes Et al.
    J Clin Invest  2013;154:1680
  6. Central and peripheral mechanisms underlying gastric distention inhibitory reflex responses in hypercapnic-acidotic rats.
    Authors: Tjen-A-Looi Et al.
    Am J Physiol Heart Circ Physiol  2011;300:H1003
  7. NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology  2011;152:3842
  8. Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex.
    Authors: Huang Et al.
    Neuropsychopharmacology  2009;34:1979
  9. Blockade of adrenoreceptors inhibits the splenic response to stroke.
    Authors: Ajmo Et al.
    Cell Rep  2009;218:47
  10. Tyramine excites rat subthalamic neurons in vitro by a DA-dependent mechanism.
    Authors: Zhu Et al.
    Neuropharmacology  2007;52:1169

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