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Pramipexole dihydrochloride

Catalog #: 4174
3 Citations Datasheet
Catalog # Availability Size / Price Qty
4174/10
4174/50
Pramipexole dihydrochloride | CAS No. 104632-25-9 | Dopamine D3 Receptor Agonists
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Description: Selective D3 agonist

Chemical Name: (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride

Purity: ≥99%

Product Details
Citations (3)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pramipexole dihydrochloride is a dopamine receptor agonist exhibiting selectivity for the D3 receptor (Ki values are 0.5, 3.3, 3.9 and 3.9 nM for D3, D2S, D2L and D4 receptors respectively). Exhibits negligible affinity for D1 and D5 receptors. Displays activity in the treatment of Parkinson's disease.

Technical Data

M.Wt:
284.25
Formula:
C10H17N3S.2HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
104632-25-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Pramipexole binding and activation of cloned and expressed DA D2, D3 and D4 receptors.
    Mierau et al.
    Eur.J.Pharmacol., 1995;290:29

Product Datasheets

Citations for Pramipexole dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Pramipexole dihydrochloride include:

3 Citations: Showing 1 - 3

  1. Pramipexole inhibits astrocytic NLRP3 inflammasome activation via Drd3-dependent autophagy in a mouse model of Parkinson's disease.
    Authors: Fen Et al.
    Acta Pharmacol Sin  2023;44:32-43
  2. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    J Exp Bot  2015;11:2057
  3. A mouse model of non-motor symptoms in Parkinson's disease: focus on pharmacological interventions targeting affective dysfunctions.
    Authors: Bonito-Oliva Et al.
    Front Behav Neurosci  2014;8:290

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