(±)-PPCC oxalate
Chemical Name: (1R,2S)-rel-2-[(4-Hydroxy-4-phenyl-1-piperidinyl)methyl]-1-(4-methylphenyl)-cyclopropanecarboxylic acid methyl ester oxalate
Purity: ≥99%
Biological Activity
(±)-PPCC oxalate is a selective sigma (σ) receptor ligand. Displays high affinity for σ1; also binds at σ2 sites (Ki = 1.5 nM and 50.8 nM respectively). Selective over a range of receptor types including dopaminergic and muscarinic receptors, DAT and SERT.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Novel sigma receptor ligands: synthesis and biological profile.
Prezzavento et al.
J.Med.Chem., 2007;50:951 -
A new sigma ligand, (±)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect.
Prezzavento et al.
Life Sci., 2008;82:549 -
Anti-amnesic properties of (±)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.
Antonini et al.
J.Neurochem., 2009;109:744
Product Datasheets
Citations for (±)-PPCC oxalate
The citations listed below are publications that use Tocris products. Selected citations for (±)-PPCC oxalate include:
6 Citations: Showing 1 - 6
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αN-Acetyl β-Endorphin Is an Endogenous Ligand of ς1Rs That Regulates Mu-Opioid Receptor Signaling by Exchanging G Proteins for ς2Rs in ς1R Oligomers.
Authors: María Et al.
Int J Mol Sci 2022;24
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The ALS-related ς1R E102Q Mutant Eludes Ligand Control and Exhibits Anomalous Response to Calcium.
Authors: María Et al.
Int J Mol Sci 2020;21
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Fenfluramine diminishes NMDA receptor-mediated seizures via its mixed activity at serotonin 5HT2A and type 1 sigma receptors.
Authors: Rodríguez-Muñoz Et al.
Oncotarget 2018;9:23373
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Sigma 1 Receptor Antagonists Inhibit Manic-Like Behaviors in Two Congenital Strains of Mice.
Authors: Sánchez-Blázquez Et al.
Int J Neuropsychopharmacol 2018;21:938
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Cannabidiol enhances MOR antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.
Authors: Rodríguez-Muñoz Et al.
Mol Brain 2018;11:51
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The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice.
Authors: Malik Et al.
J Biol Chem 2015;172:2519
FAQs
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