Porcine IL-8/CXCL8 Biotinylated Antibody Summary
Ala26-Gln104
Accession # CAA43461
Applications
Porcine IL-8/CXCL8 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-8/CXCL8
Interleukin 8 was originally discovered and purified independently by a number of laboratories as a neutrophil chemotactic and activating factor. It was also referred to as neutrophil chemotactic factor (NCF), neutrophil activating protein (NAP), monocyte-derived neutrophil chemotactic factor (MDNCF), T-lymphocyte chemotactic factor (TCF), granulocyte chemotactic protein (GCP) and leukocyte adhesion inhibitor (LAI). Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce IL-8 in response to a wide variety of
pro‑inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. IL-8 is a member of the alpha (C-X-C) subfamily of chemokines, which also includes platelet factor 4, GRO, IP-10, etc.
IL-8 is a potent chemoattractant for neutrophils. In addition, IL-8 also has a wide range of other pro-inflammatory effects. IL-8 causes degranulation of neutrophil specific granules and azurophilic granules. IL-8 induces expression of the cell adhesion molecules CD11/CD18 and enhances the adherence of neutrophils to endothelial cells and sub-endothelial matrix proteins. Besides neutrophils, IL-8 is also chemotactic for basophils, T cells and eosinophils. IL-8 has been reported to be a co-mitogen for keratinocytes and was also shown to be an autocrine growth factor for melanoma cells. IL-8 has also been reported to be angiogenic both in vivo and in vitro.
- Van Damme, J. et al. (1998) in The Cytokine Handbook, A.W. Thomson ed., Academic Press, New York. p. 271.
Product Datasheets
Citations for Porcine IL-8/CXCL8 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes
Authors: DE Marin, CV Bulgaru, CA Anghel, GC Pistol, MI Dore, ML Palade, I Taranu
Toxins, 2020-12-15;12(12):.
Species: Porcine
Sample Types: Tissue Homogenates
Applications: ELISA Detection -
Development and validation of a multiplex fluorescent microsphere immunoassay assay for detection of porcine cytokines
Authors: SA Hall, SH Ison, C Owles, J Coe, DA Sandercock, AJ Zanella
MethodsX, 2019-05-17;6(0):1218-1227.
Species: Porcine
Sample Types: Tissue Homogenates
Applications: ELISA Detection -
Protective Role of Passively Transferred Maternal Cytokines against Bordetella pertussis Infection in Newborn Piglets
Authors: S Elahi, DR Thompson, J Van Kessel, LA Babiuk, V Gerdts
Infect. Immun., 2017-03-23;85(4):.
Species: Porcine
Sample Types: Serum
Applications: ELISA Development (Detection) -
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model
Authors: P Maisonnasse, E Bouguyon, G Piton, A Ezquerra, C Urien, C Deloizy et al.
Mucosal Immunology
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The effect of activated protein C on plasma cytokine levels in a porcine model of acute endotoxemia.
Authors: Nielsen JS, Larsson A, Rix T, Nyboe R, Gjedsted J, Krog J, Ledet T, Tonnesen E
Intensive Care Med, 2007-04-25;33(6):1085-93.
Species: Human
Sample Types: Plasma
Applications: ELISA Development -
Simultaneous detection of porcine proinflammatory cytokines using multiplex flow cytometry by the xMAP technology.
Authors: Johannisson A, Jonasson R, Dernfalk J, Jensen-Waern M
Cytometry A, 2006-05-01;69(5):391-5.
Species: Porcine
Sample Types: Serum
Applications: Luminex Development -
Acute hyperinsulinemia restrains endotoxin-induced systemic inflammatory response: an experimental study in a porcine model.
Authors: Brix-Christensen V, Andersen SK, Andersen R, Mengel A, Dyhr T, Andersen NT, Schmitz O, Orskov H, Tonnesen E
Anesthesiology, 2004-04-01;100(4):861-70.
Species: Porcine
Sample Types: Plasma
Applications: ELISA Development -
Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells.
Authors: Bensaude E, Turner JL, Wakeley PR, Sweetman DA, Pardieu C, Drew TW, Wileman T, Powell PP
J. Gen. Virol., 2004-04-01;85(0):1029-37.
Species: Porcine
Sample Types: Cell Culture Supernates
Applications: ELISA Development
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