Polybrene
Chemical Name: 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
Purity: ≥95%
Biological Activity
Polybrene is a cationic polymer that improves lentiviral and adenoviral transduction efficiency in mammalian cells in vitro. It also enhances DNA transfection in many types of cells. It has a neutralizing effect on negatively charged DNA and viral particles which facilitates their attachment and entry into host cells. Polybrene is suitable for use with CRISPR/Cas9 protocols.Polybrene is a lyophilized solid and can be prepared as a stock solution by adding 1 mL of sterile ultra-pure water directly to the vial (final stock concentration 10 mg/mL).
For further information view the product protocol.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets
Citation for Polybrene
The citations listed below are publications that use Tocris products. Selected citations for Polybrene include:
1 Citation: Showing 1 - 1
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Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
Authors: Yoshitasu Et al.
iScience 2023;26:106623
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