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(+)-JQ1 PA

Catalog #: 6589
1 Citation Datasheet

Discontinued Product

6589 has been discontinued.
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(+)-JQ1 PA | CAS No. 2115701-93-2 | Degrader Building Blocks
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Description: Functionalized BET bromodomain inhibitor; 'click' target ligand for PROTACs

Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-N-2-propyn-1-yl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

Purity: ≥95%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

(+)-JQ1 PA is a click-activated (alkyne) version of the BET bromodomain inhibitor (+)-JQ1 (Cat. No. 4499). Can be used as a precursor to a PROTAC® targeting BET bromodomains. Supplied with an alkyne functionalized handle for click conjugation to a linker/E3 ligase ligand. Can also be conjugated to fluorescent dyes for imaging aplications.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
437.95
Formula:
C22H20ClN5OS
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
2115701-93-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Click chemistry enables preclinical evaluation of targeted epigenetic therapies.
    Tyler et al.
    Science, 2017;356:1397

Product Datasheets

Citation for (+)-JQ1 PA

The citations listed below are publications that use Tocris products. Selected citations for (+)-JQ1 PA include:

1 Citation: Showing 1 - 1

  1. Small molecule JQ1 promotes prostate cancer invasion via BET-independent inactivation of FOXA1.
    Authors: Sophia Y Et al.
    J Clin Invest  2020;130:1782-1792

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