PKUMDL WQ 2201

Catalog #: 6581 Datasheet

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PKUMDL WQ 2201 | CAS No. 592474-91-4 | Dehydrogenase Inhibitors

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Description: Negative allosteric modulator of 3-Phosphoglycerate dehydrogenase (PHGDH)

Chemical Name: 2-Chloro-4-[5-[[2-[(ethylamino)thioxomethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PKUMDL WQ 2201 is a negative allosteric modulator of phosphoglycerate dehydrogenase (PHGDH) (IC₅₀ = 35.7 μM). Displays dose-dependent suppression of cell viability in a range of cancer cell lines. Inhibits tumor growth in a xenograft mouse model.

Technical Data

M.Wt:

351.81

Formula:

C₁₅H₁₄ClN₃O₃S

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

592474-91-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Rational design of selective allosteric inhibitors of PHGDH and serine synthesis with anti-tumor activity.
Wang et al.
Cell Chem.Biol., 2017;24:55

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