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PI 828

Catalog #: 2814
5 Citations Datasheet
Catalog # Availability Size / Price Qty
2814/1
PI 828 | CAS No. 942289-87-4 | PI 3-Kinase Inhibitors
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Description: PI 3-kinase inhibitor, more potent than LY 294002 (Cat. No. 1130)

Chemical Name: 2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one

Purity: ≥98%

Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PI 828 is a PI 3-Kinase inhibitor (IC50 values are 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively) that displays higher potency than LY 294002 (Cat No. 1130). Can be immobilized onto a solid phase.

Technical Data

M.Wt:
322.36
Formula:
C19H18N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
942289-87-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1? and VEGF receptors
    N Mahfouz, R Tahtouh, N Alaaeddine, J El Hajj, R Sarkis, R Hachem, I Raad, G Hilal
    PLoS ONE, 2017;12(6):e0179202.
  2. Multiple roles of the SO4(2-)/Cl-/OH- exchanger protein Slc26a2 in chondrocyte functions.
    Park, Meeyoung, Ohana, Ehud, Choi, Soo Youn, Lee, Myeong-S, Park, Jong Hoo, Muallem, Shmuel
    J Biol Chem, 2014;289(4):1993-2001.
  3. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy.
    Kulkarni A, Roy B, Rao P, Wyant G, Mahmoud A, Ramachandran M, Sengupta P, Goldman A, Kotamraju V, Basu S, Mashelkar R, Ruoslahti E, Dinulescu D, Sengupta S
    Cancer Res, 2013;73(23):6987-97.
  4. Exploring the specificity of the PI3K family inhibitor LY294002.
    Gharbi et al.
    Biochem.J., 2007;404:15

Product Datasheets

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Citations for PI 828

The citations listed below are publications that use Tocris products. Selected citations for PI 828 include:

5 Citations: Showing 1 - 5

  1. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
    Authors: Liddell Et al.
    J Neuroinflammation  2016;13:49
  2. Upregulation of Nicotinic Acetylcholine Receptor α4+β2 through a Ligand-Independent PI3Kβ Mechanism That Is Enhanced by TNFα and the Jak2/p38Mapk Pathways.
    Authors: Rogers and Gahring
    J Neurosci  2015;10:e0143319
  3. Functional kinomics identifies candidate therapeutic targets in head and neck cancer.
    Authors: Moser Et al.
    Clin Cancer Res  2014;20:4274
  4. The expression and relaxant effect of bitter taste receptors in human bronchi.
    Authors: Grassin-Delyle Et al.
    Respir Res  2013;14:134
  5. TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles.
    Authors: Li Et al.
    Environ Health Perspect  2011;119:784

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