Home / Ubiquitin Ligase (E3) Inhibitors / PFI 7

PFI 7

Catalog #: 7960 Datasheet
Catalog # Availability Size / Price Qty
7960/10
7960/50
PFI 7 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective GID4 antagonist

Chemical Name: N-((1s,4s)-4-(1H-Benzo[d]imidazol-2-yl)cyclohexyl)-2-(((1H-indol-2-yl)methyl)amino)acetamide dihydrochloride

Purity: ≥98%

Product Details
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Biological Activity Technical Data Additional Information Product Datasheets Calculators

Biological Activity

PFI 7 is a selective GID4 antagonist (Kd = 80 nM by SPR assays and EC50 = 0.6 μM by cell-based NanoBRET). PFI 7 binds within the �-barrel of GID4 substrate binding pocket, disrupting its interaction with the canonical Pro/N-degron peptide in live cells. It alters protein levels of several proteins including RNA helicases as measured by quantitative proteomics.

Technical Data

M.Wt:
474.43
Formula:
C24H27N5O.2HCl
Solubility:
Soluble to 100 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the PFI 7 probe summary on the SGC website.

Product Datasheets

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