Home / Casein Kinase 1 Inhibitors / PF 4800567 hydrochloride

PF 4800567 hydrochloride

Catalog #: 4281
5 Citations Datasheet
Catalog # Availability Size / Price Qty
4281/10
4281/50
PF 4800567 hydrochloride | CAS No. 1391052-28-0 | Casein Kinase 1 Inhibitors
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Description: Selective casein kinase 1ε inhibitor

Chemical Name: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine hydrochloride

Purity: ≥99%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 4800567 hydrochloride is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 4800567 is reviewed on the chemical probes website.

Technical Data

M.Wt:
396.27
Formula:
C17H18ClN5O2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
1391052-28-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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Citations for PF 4800567 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for PF 4800567 hydrochloride include:

5 Citations: Showing 1 - 5

  1. Methods for High-throughput Drug Combination Screening and Synergy Scoring.
    Authors: Jing Et al.
    Methods Mol Biol  2018;1711:351-398
  2. Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis.
    Authors: Oren Et al.
    Mol Biol Cell  2015;5:11418
  3. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
    Authors: Cheong Et al.
    J Clin Invest  2015;125:1401
  4. CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.
    Authors: Zemp Et al.
    J Cell Sci  2014;127:1242
  5. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra.
    Authors: Zhang Et al.
    Curr Biol  2013;23:1863

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