PF 3845
Chemical Name: N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Purity: ≥99%
Biological Activity
PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders.
Ahn et al.
Expert Opin.Drug Discov., 2009;4:763 -
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Ahn et al.
Chem.Biol., 2009;16:411
Product Datasheets
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