PF 184

Catalog #: 4238
3 Citations Datasheet

Catalog #	Availability	Size / Price	Qty
4238/10

PF 184 | CAS No. 1187460-81-6 | IkB Kinase Inhibitors

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Description: Potent and selective IKKβ inhibitor

Chemical Name: 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide

Purity: ≥98%

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Product Details

Citations (3)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

PF 184 is a potent and selective IKKβ inhibitor (IC₅₀ = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1β-induced TNF-α production in a steroid-insensitive in vitro model of oxidative stress.

Technical Data

M.Wt:

619.09

Formula:

C₃₂H₃₂ClFN₆O₄

Solubility:

Soluble to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1187460-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc.

Background References

Novel tight-binding inhibitory factor-κB kinase (IKK-2) inhibitors demostrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation.
Sommers et al.
J.Pharmacol.Exp.Ther., 2009;330:377

Product Datasheets

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Citations for PF 184

The citations listed below are publications that use Tocris products. Selected citations for PF 184 include:

3 Citations: Showing 1 - 3

In vitro benchmarking of NF-κB inhibitors.
Authors: Charles Et al.
Eur J Pharmacol 2020;873:172981
Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING.
Authors: Michael Et al.
Mol Cell 2019;74:801-815.e6
Bindarit: an anti-inflammatory small molecule that modulates the NFκB pathway.
Authors: Mora Et al.
Cell Cycle 2012;11:159

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