Perhexiline maleate
Chemical Name: 2-(2,2-Dicyclohexylethyl)piperidine maleate
Purity: ≥99%
Biological Activity
Perhexiline maleate is a carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor. Inhibits palmitate oxidation in rat cardiomyocytes and increases cardiac efficiency in isolated rat hearts. Antianginal.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.
Unger et al.
J.Cardiovasc.Pharmacol., 2005;46:849 -
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.
Yin et al.
J.Mol.Cell.Cardiol., 2013;55:27 -
Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiod.
Kennedy et al.
Biochem.Pharmacol., 1996;52:273
Product Datasheets
Citation for Perhexiline maleate
The citations listed below are publications that use Tocris products. Selected citations for Perhexiline maleate include:
1 Citation: Showing 1 - 1
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Microglial metabolic flexibility supports immune surveillance of the brain parenchyma.
Authors: Louis-Philippe Et al.
Nat Commun 2020;11:1559
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