Pentylenetetrazole
Chemical Name: 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine
Purity: ≥99%
Biological Activity
Pentylenetetrazole is a cNS stimulant that induces kindling in vivo. Causes alterations in excitatory and inhibitory neurotransmitter systems.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Hartman A, Santos P, Dolce A, Hardwick J
PLoS ONE, 2012;7(9):e45156. -
Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems.
Rocha et al.
Epilepsy Res., 1996;26:105 -
Acute pentylenetetrazol injection reduces rat GABAA receptor mRNA levels and GABA stimulation of benzodiazepine binding with no effect on benzodiazepine binding site density.
Walsh et al.
J.Pharmacol.Exp.Ther., 1999;289:1626 -
Effect of cyclooxygenase inhibitors on pentylenetetrazol (PTZ)-induced convulsions: possible mechanism of action.
Dhir et al.
Prog.Neuro-Psychopharm.Biol.Psychiat., 2006;30:1478
Product Datasheets
Citation for Pentylenetetrazole
The citations listed below are publications that use Tocris products. Selected citations for Pentylenetetrazole include:
1 Citation: Showing 1 - 1
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2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors.
Authors: Karim Et al.
Br J Pharmacol 2012;165:880
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