PEAQX tetrasodium salt
Chemical Name: [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Purity: ≥98%
Biological Activity
PEAQX tetrasodium salt is a potent NMDA receptor antagonist (IC50 = 8 nM). Exhibits >100-fold selectivity for hGluN2A (formally hNR2A) containing receptors over hGluN2B (hNR2B). Anticonvulsant in vivo.Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
Auberson et al.
Bioorg.Med.Chem.Lett., 2002;12:1099
Product Datasheets
Citations for PEAQX tetrasodium salt
The citations listed below are publications that use Tocris products. Selected citations for PEAQX tetrasodium salt include:
2 Citations: Showing 1 - 2
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Ca2+ signaling in postsynaptic neurons: Neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors.
Authors: Eckart D Et al.
Cell Calcium 2022;106:102623
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Anticonvulsant Action of GluN2A-Preferring Antagonist PEAQX in Developing Rats.
Authors: Pavel Et al.
Pharmaceutics 2021;13
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