PDEδ ATTEC 12C New

Catalog #: 8824 Datasheet

Catalog #	Availability	Size / Price	Qty
8824/5

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Description: PDEδ autophagy-tethering compound (ATTEC) Degrader

Chemical Name: N-(6-(2-(2,6-Dibromo-4-((5-iodo-2-oxoindolin-3-ylidene)methyl)phenoxy)acetamido)hexyl)-4-(3,4-dimethyl-7-oxo-2-(p-tolyl)-2,7-dihydro-6H-pyrazolo[3,4-d]pyridazin-6-yl)butanamide

Purity: ≥98%

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Biological Activity

PDEδ ATTEC 12C is a selective PDEδ autophagy-tethering compound (ATTEC) Degrader (DC₅₀ = 1.7 μM; D_max = 85%; K_d = 56 nM). Degrades PDEδ through lysosome-mediated autophagy. Inhibits proliferation of KRAS mutant Capan-1 and MiaPaCa-2 pancreatic cancer cells (IC₅₀ values are 0.8 μM and 1.4 μM respectively); dose- and time-dependently induces apoptosis.

Technical Data

M.Wt:

999.54

Formula:

C₄₁H₄₂Br₂IN₇O₅

Solubility:

Soluble to 20 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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