Pan Caspase Inhibitor Z-VAD-FMK

The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies
Authors: Ragucci, S;Landi, N;Citores, L;Iglesias, R;Russo, R;Clemente, A;Saviano, M;Pedone, PV;Chambery, A;Ferreras, JM;Di Maro, A;
International journal of molecular sciences  2023-09-22

KMU-191 Induces Apoptosis in Human Clear Cell Renal Cell Carcinoma Caki Cells Through Modulation of Bcl-xL, Mcl-1 (L), c-FLIP (L), and p53 Proteins
Authors: Kim, S;Kim, DE;Kang, H;Hong, VS;Jeon, J;Lee, J;Kim, KS;Park, JW;
Journal of Cancer  2023-07-16

SIRT1 Regulates Hepatocyte Programmed Cell Death via GSDME - IL18 Axis in Human and Mouse Liver Transplantation
Authors: Kadono, K;Kojima, H;Yao, S;Kageyama, S;Nakamura, K;Hirao, H;Ito, T;Dery, K;Farmer, D;Kaldas, F;Li, X;Kupiec-Weglinski, J;
Research square  2023-06-27

Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer Cells
Authors: M Montagnani, G Beretta, RM Moretti
International Journal of Molecular Sciences, 2023-03-03;24(5):.  2023-03-03

Mechanism of cis-Nerolidol-Induced Bladder Carcinoma Cell Death
Authors: M Glumac, V ?ikeš ?uli, I Marinovi?-, M Radan
Cancers, 2023-02-03;15(3):.  2023-02-03

Dual inhibition of thioredoxin reductase and proteasome is required for auranofin-induced paraptosis in breast cancer cells
Authors: MJ Seo, IY Kim, DM Lee, YJ Park, MY Cho, HJ Jin, KS Choi
Cell Death & Disease, 2023-01-19;14(1):42.  2023-01-19

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells
Authors: CDB Gamage, JH Kim, Y Yang, ? Ta?, SY Park, R Zhou, S Pulat, M Varl?, JS Hur, SJ Nam, H Kim
Cancers, 2023-01-12;15(2):.  2023-01-12

Galectin-9 has non-apoptotic cytotoxic activity towards Acute Myeloid Leukemia independent of cytarabine resistance
Authors: Wiersma, V;Choukrani, G;Visser, N;Avtenyuk, N;Olthuis, M;Marsman, G;Ammatuna, E;Lourens, H;Niki, T;Huls, G;Bremer, E;
Research Square  2023-01-01

JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation
Authors: G Lee, H Ahn, JH Yun, J Park, E Lee, S Oh, GS Lee
Scientific Reports, 2022-12-28;12(1):22484.  2022-12-28

AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology
Authors: L Tilokani, FM Russell, S Hamilton, DM Virga, M Segawa, V Paupe, AV Gruszczyk, M Protasoni, LC Tabara, M Johnson, H Anand, MP Murphy, DG Hardie, F Polleux, J Prudent
Science Advances, 2022-11-11;8(45):eabo7956.  2022-11-11

TRAF3/p38-JNK Signalling Crosstalk with Intracellular-TRAIL/Caspase-10-Induced Apoptosis Accelerates ROS-Driven Cancer Cell-Specific Death by CD40
Authors: K Ibraheem, AMA Yhmed, MM Nasef, NT Georgopoul
Cells, 2022-10-18;11(20):.  2022-10-18

Vitamin C Suppresses Pancreatic Carcinogenesis through the Inhibition of Both Glucose Metabolism and Wnt Signaling
Authors: JH Kim, S Hwang, JH Lee, SS Im, J Son
International Journal of Molecular Sciences, 2022-10-14;23(20):.  2022-10-14

Inhibition of USP1 enhances anticancer drugs-induced cancer cell death through downregulation of survivin and miR-216a-5p-mediated upregulation of DR5
Authors: SM Woo, S Kim, SU Seo, S Kim, JW Park, G Kim, YR Choi, K Hur, TK Kwon
Cell Death & Disease, 2022-09-24;13(9):821.  2022-09-24

DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cells
Authors: YS Michaels, JM Edgar, MC Major, EL Castle, C Zimmerman, T Yin, A Hagner, C Lau, HH Hsu, MI Ibañez-Rio, LJ Durland, DJHF Knapp, PW Zandstra
Science Advances, 2022-08-24;8(34):eabn5522.  2022-08-24

Isolation, Characterization and Biological Action of Type-1 Ribosome-Inactivating Proteins from Tissues of Salsola soda L
Authors: N Landi, S Ragucci, L Citores, A Clemente, HZF Hussain, R Iglesias, JM Ferreras, A Di Maro
Toxins, 2022-08-19;14(8):.  2022-08-19

Magmas Inhibition in Prostate Cancer: A Novel Target for Treatment-Resistant Disease
Authors: J Yang, BC Das, O Aljitawi, A Kumar, S Das, P Van Veldhu
Cancers, 2022-05-31;14(11):.  2022-05-31

Chemotherapy-induced COX-2 upregulation by cancer cells defines their inflammatory properties and limits the efficacy of chemoimmunotherapy combinations
Authors: CR Bell, VS Pelly, A Moeini, SC Chiang, E Flanagan, CP Bromley, C Clark, CH Earnshaw, MA Koufaki, E Bonavita, S Zelenay
Nature Communications, 2022-04-19;13(1):2063.  2022-04-19

Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes
Authors: D Beillevair, F Migneault, J Turgeon, D Gingras, AK Rimbaud, G Marcoux, C Spino, N Thibodeau, E Bonneil, P Thibault, É Boilard, M Dieudé, MJ Hébert
Cell Death & Disease, 2022-02-11;13(2):145.  2022-02-11

Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis
Authors: W Deng, Y Bai, F Deng, Y Pan, S Mei, Z Zheng, R Min, Z Wu, W Li, R Miao, Z Zhang, TS Kupper, J Lieberman, X Liu
Nature, 2022-02-02;0(0):.  2022-02-02

FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury
Authors: B Lee, Y Oh, E Cho, A DiAntonio, V Cavalli, JE Shin, HW Choi, Y Cho
The Journal of Biological Chemistry, 2022-01-29;0(0):101647.  2022-01-29

Galectin-9 Triggers Neutrophil-Mediated Anticancer Immunity
Authors: N Ustyanovsk, G Choukrani, E Ammatuna, T Niki, E Cendrowicz, HJ Lourens, G Huls, VR Wiersma, E Bremer
Biomedicines, 2021-12-29;10(1):.  2021-12-29

Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
International Journal of Molecular Sciences, 2021-12-21;23(1):.  2021-12-21

Apigenin Induces Autophagy and Cell Death by Targeting EZH2 under Hypoxia Conditions in Gastric Cancer Cells
Authors: TW Kim, HG Lee
International Journal of Molecular Sciences, 2021-12-15;22(24):.  2021-12-15

AKF-D52, a Synthetic Phenoxypyrimidine-Urea Derivative, Triggers Extrinsic/Intrinsic Apoptosis and Cytoprotective Autophagy in Human Non-Small Cell Lung Cancer Cells
Authors: HS Gil, JH Lee, AK Farag, AHE Hassan, KS Chung, JH Choi, EJ Roh, KT Lee
Oncogene, 2021-11-22;13(22):.  2021-11-22

LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
Authors: P Li, Q Li, N Biswas, H Xin, T Diemer, L Liu, L Perez Guti, G Paternostr, C Piermarocc, S Domanskyi, RK Wang, N Ferrara
Embo Molecular Medicine, 2021-11-15;0(0):e14511.  2021-11-15

Apoptosis Enhances the Replication of Human Coronavirus OC43
Authors: S Maharjan, M Kang, J Kim, D Kim, S Park, M Kim, K Baek, Y Lee, HJ Kwon
Viruses, 2021-11-01;13(11):.  2021-11-01

Species-Specific Inhibition of Necroptosis by HCMV UL36
Authors: E Muscolino, C Castiglion, R Brixel, G Frascaroli, W Brune
Viruses, 2021-10-22;13(11):.  2021-10-22

PI3Kdelta coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T�cells at the expense of central memory
Authors: JL Cannons, AV Villarino, SM Kapnick, S Preite, HY Shih, J Gomez-Rodr, Z Kaul, H Shibata, JM Reilley, B Huang, R Handon, IT McBain, S Gossa, T Wu, HC Su, DB McGavern, JJ O'Shea, PJ McGuire, G Uzel, PL Schwartzbe
Cell Reports, 2021-10-12;37(2):109804.  2021-10-12

Charting the N-Terminal Acetylome: A Comprehensive Map of Human NatA Substrates
Authors: P Van Damme
International Journal of Molecular Sciences, 2021-10-02;22(19):.  2021-10-02

Parabens disrupt non-canonical inflammasome activation
Authors: H Ahn, H Lee, G Lee, J Park, HW Sung, E Lee, GS Lee
International immunopharmacology, 2021-09-30;101(0):108196.  2021-09-30

Caspase-Dependent HMGB1 Release from Macrophages Participates in Peripheral Neuropathy Caused by Bortezomib, a Proteasome-Inhibiting Chemotherapeutic Agent, in Mice
Authors: M Tsubota, T Miyazaki, Y Ikeda, Y Hayashi, Y Aokiba, S Tomita, F Sekiguchi, D Wang, M Nishibori, A Kawabata
Cells, 2021-09-27;10(10):.  2021-09-27

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization
Authors: K Wu, SM Woo, SU Seo, TK Kwon
International Journal of Molecular Sciences, 2021-09-18;22(18):.  2021-09-18

Selenium-GPX4 axis protects follicular helper T cells from ferroptosis
Authors: Y Yao, Z Chen, H Zhang, C Chen, M Zeng, J Yunis, Y Wei, Y Wan, N Wang, M Zhou, C Qiu, Q Zeng, HS Ong, H Wang, FV Makota, Y Yang, Z Yang, N Wang, J Deng, C Shen, Y Xia, L Yuan, Z Lian, Y Deng, C Guo, A Huang, P Zhou, H Shi, W Zhang, H Yi, D Li, M Xia, J Fu, N Wu, JB de Haan, N Shen, W Zhang, Z Liu, D Yu
Nature Immunology, 2021-08-19;22(9):1127-1139.  2021-08-19

Synergistic Antitumor Activity of SH003 and Docetaxel via EGFR Signaling Inhibition in Non-Small Cell Lung Cancer
Authors: MS Jeong, KW Lee, YJ Choi, YG Kim, HH Hwang, SY Lee, SE Jung, SA Park, JH Lee, YJ Joo, SG Cho, SG Ko
International Journal of Molecular Sciences, 2021-08-05;22(16):.  2021-08-05

The exon-junction complex helicase eIF4A3 controls cell fate via coordinated regulation of ribosome biogenesis and translational output
Authors: DC Kanellis, JA Espinoza, A Zisi, E Sakkas, J Bartkova, AM Katsori, J Boström, L Dyrskjøt, H Broholm, M Altun, SJ Elsässer, MS Lindström, J Bartek
Science Advances, 2021-08-04;7(32):.  2021-08-04

N-3-Hydroxy Dodecanoyl-DL-homoserine Lactone (OH-dDHL) Triggers Apoptosis of Bone Marrow-Derived Macrophages through the ER- and Mitochondria-Mediated Pathways
Authors: K Woo, DH Kim, MH Oh, HS Park, CH Choi
International Journal of Molecular Sciences, 2021-07-15;22(14):.  2021-07-15

3-Methyladenine prevents energy stress-induced necrotic death of melanoma cells through autophagy-independent mechanisms
Authors: M Kosic, V Paunovic, B Ristic, A Mircic, M Bosnjak, D Stevanovic, T Kravic-Ste, V Trajkovic, L Harhaji-Tr
Journal of pharmacological sciences, 2021-06-11;147(1):156-167.  2021-06-11

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer
Authors: C Mao, X Liu, Y Zhang, G Lei, Y Yan, H Lee, P Koppula, S Wu, L Zhuang, B Fang, MV Poyurovsky, K Olszewski, B Gan
Nature, 2021-05-12;0(0):.  2021-05-12

Characterization of HIV-induced remodeling reveals differences in infection susceptibility of memory CD4+ T�cell subsets in�vivo
Authors: G Xie, X Luo, T Ma, J Frouard, J Neidleman, R Hoh, SG Deeks, WC Greene, NR Roan
Cell Reports, 2021-04-27;35(4):109038.  2021-04-27

Netrin-1 receptor UNC5C cleavage by active &delta-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies
Authors: G Chen, SS Kang, Z Wang, EH Ahn, Y Xia, X Liu, IM Sandoval, FP Manfredsso, Z Zhang, K Ye
Science Advances, 2021-04-16;7(16):.  2021-04-16

Selective Anti-Cancer Effects of Plasma-Activated Medium and Its High Efficacy with Cisplatin on Hepatocellular Carcinoma with Cancer Stem Cell Characteristics
Authors: Y Li, T Tang, HJ Lee, K Song
International Journal of Molecular Sciences, 2021-04-12;22(8):.  2021-04-12

ABT?737, a Bcl?2 family inhibitor, has a synergistic effect with apoptosis by inducing urothelial carcinoma cell necroptosis
Authors: R Cheng, X Liu, Z Wang, K Tang
Molecular Medicine Reports, 2021-03-31;23(6):.  2021-03-31

Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells
Authors: Q Zhong, TI Roumelioti, Z Kozik, M Cepeda-Mol, LÁ Fernández, AR Shenoy, C Bakal, G Frankel, JS Choudhary
PloS Biology, 2020-12-30;18(12):e3000986.  2020-12-30

Novel Small Molecular Compound AE-848 Potently Induces Human Multiple Myeloma Cell Apoptosis by Modulating the NF-&kappaB and PI3K/Akt/mTOR Signaling Pathways
Authors: Y Xu, X Feng, Q Zhou, W Jiang, Y Dai, Y Jiang, X Liu, S Li, Y Wang, F Wang, A Li, C Zheng
OncoTargets and Therapy, 2020-12-22;13(0):13063-13075.  2020-12-22

Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
Authors: KM Lee, H Lee, D Han, WK Moon, K Kim, HJ Oh, J Choi, EH Hwang, SE Kang, SA Im, KH Lee, HS Ryu
Breast Cancer Res, 2020-11-25;22(1):130.  2020-11-25

Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells
Authors: KJ Min, TK Kwon
Cancers (Basel), 2020-11-16;12(11):.  2020-11-16

Synergistic apoptotic effects in cancer cells by the combination of CLK and Bcl-2 family inhibitors
Authors: A Murai, S Ebara, S Sasaki, T Ohashi, T Miyazaki, T Nomura, S Araki
PLoS ONE, 2020-10-16;15(10):e0240718.  2020-10-16

Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines
Authors: CA Iannuzzi, P Indovina, IM Forte, S Di Somma, AM Malfitano, M Bruno, G Portella, F Pentimalli, A Giordano
Int J Mol Sci, 2020-10-04;21(19):.  2020-10-04

The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
EBioMedicine, 2020-09-23;60(0):102984.  2020-09-23

Reduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death
Authors: SY Park, HH Park, SY Park, SM Hong, S Yoon, MJ Morgan, YS Kim
Cell Death Dis, 2020-09-11;11(9):744.  2020-09-11

Cryptotanshinone chemosensitivity potentiation by TW-37 in human oral cancer cell lines by targeting STAT3-Mcl-1 signaling
Authors: IH Yang, SH Hong, M Jung, CH Ahn, HJ Yoon, SD Hong, SD Cho, JA Shin
Cancer Cell Int., 2020-08-26;20(0):405.  2020-08-26

Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
Authors: SA Shahriyar, SU Seo, KJ Min, P Kubatka, DS Min, JS Chang, DE Kim, SM Woo, TK Kwon
Cancers (Basel), 2020-08-21;12(9):.  2020-08-21

Involvement of the NF-&kappaB signaling pathway in proliferation and invasion inhibited by Zwint-1 deficiency in Pancreatic Cancer Cells
Authors: JH Kim, Y Youn, JC Lee, J Kim, JH Hwang
Journal of Cancer, 2020-07-25;11(19):5601-5611.  2020-07-25

Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma
Authors: J Wang, K Sato, E O'Donnell, A Singla, S Yaguare, O Aldahamshe, B Batko, H Borjihan, J Tingling, J Zhang, DA Weiser, DM Loeb, R Gorlick, EL Schwartz, R Yang, X Zi, H Zhao, DS Geller, BH Hoang
Transl Oncol, 2020-07-02;13(10):100809.  2020-07-02

Dual role of phosphatidylserine and its receptors in osteoclastogenesis
Authors: JH Kang, HM Ko, GD Han, SY Lee, JS Moon, MS Kim, JT Koh, SH Kim
Cell Death Dis, 2020-07-01;11(7):497.  2020-07-01

Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid beta-Protein-Induced Synapse Loss in Alzheimer's Disease
Authors: G Park, HS Nhan, SH Tyan, Y Kawakatsu, C Zhang, M Navarro, EH Koo
Cell Rep, 2020-06-30;31(13):107839.  2020-06-30

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and beta-catenin induction in mesothelium
Authors: F Ito, I Yanatori, Y Maeda, K Nimura, S Ito, T Hirayama, H Nagasawa, N Kohyama, Y Okazaki, S Akatsuka, S Toyokuni
Redox Biol, 2020-06-24;36(0):101616.  2020-06-24

Chrysophanol Regulates Cell Death, Metastasis, and Reactive Oxygen Species Production in Oral Cancer Cell Lines
Authors: PC Hsu, CF Cheng, PC Hsieh, YH Chen, CY Kuo, HK Sytwu
Evid Based Complement Alternat Med, 2020-05-26;2020(0):5867064.  2020-05-26

Monoglyceride lipase mediates tumor-suppressive effects by promoting degradation of X-linked inhibitor of apoptosis protein
Authors: R Liu, X Wang, C Curtiss, MS Sheikh, Y Huang
Cell Death Differ., 2020-05-06;0(0):.  2020-05-06

Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells
Authors: A Kratochvíl, B Veselá, V Ledvina, E Švandová, K Klepárník, K Dadáková, P Beneš, E Matalová
Sci Rep, 2020-05-04;10(1):7489.  2020-05-04

PERK/NRF2 and autophagy form a resistance mechanism against G9a inhibition in leukemia stem cells
Authors: JE Jang, JI Eom, HK Jeung, H Chung, YR Kim, JS Kim, JW Cheong, YH Min
J. Exp. Clin. Cancer Res., 2020-04-15;39(1):66.  2020-04-15

Combination of Arsenic Trioxide and Valproic Acid Efficiently Inhibits Growth of Lung Cancer Cells via G2/M-Phase Arrest and Apoptotic Cell Death
Authors: HK Park, BR Han, WH Park
Int J Mol Sci, 2020-04-10;21(7):.  2020-04-10

Activation of JNK signaling promotes all-trans retinal-induced photoreceptor apoptosis in mice
Authors: C Liao, B Cai, Y Feng, J Chen, Y Wu, J Zhuang, Z Liu, Y Wu
J. Biol. Chem., 2020-04-07;0(0):.  2020-04-07

Energy-stress-mediated AMPK activation inhibits ferroptosis
Authors: H Lee, F Zandkarimi, Y Zhang, JK Meena, J Kim, L Zhuang, S Tyagi, L Ma, TF Westbrook, GR Steinberg, D Nakada, BR Stockwell, B Gan
Nat. Cell Biol., 2020-02-06;22(2):225-234.  2020-02-06

BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis
Authors: J Mann, N Yang, R Montpetit, R Kirschenma, H Lemieux, IS Goping
Sci Rep, 2020-01-15;10(1):355.  2020-01-15

Regulation of Eosinophil Recruitment and Allergic Airway Inflammation by Tropomyosin Receptor Kinase A
Authors: M Dileepan, XN Ge, I Bastan, YG Greenberg, Y Liang, P Sriramarao, SP Rao
J. Immunol., 2019-12-23;0(0):.  2019-12-23

Lercanidipine Synergistically Enhances Bortezomib Cytotoxicity in Cancer Cells via Enhanced Endoplasmic Reticulum Stress and Mitochondrial Ca2+ Overload
Authors: AR Lee, MJ Seo, J Kim, DM Lee, IY Kim, MJ Yoon, H Hoon, KS Choi
Int J Mol Sci, 2019-12-04;20(24):.  2019-12-04

Non-SMC condensin I complex subunit H mediates mature chromosome condensation and DNA damage in pancreatic cancer cells
Authors: JH Kim, Y Youn, KT Kim, G Jang, JH Hwang
Sci Rep, 2019-11-29;9(1):17889.  2019-11-29

Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin
Authors: DE Kim, MET Dollé, WP Vermeij, A Gyenis, K Vogel, JHJ Hoeijmaker, CD Wiley, AR Davalos, P Hasty, PY Desprez, J Campisi
Aging Cell, 2019-11-18;0(0):e13072.  2019-11-18

PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
Authors: S Yan, N Zhou, D Zhang, K Zhang, W Zheng, Y Bao, W Yang
Int J Mol Sci, 2019-10-30;20(21):.  2019-10-30

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1
Authors: SP O'Hara, PL Splinter, CE Trussoni, E Guicciardi, NP Splinter, MS Al Suraih, N Nasser-Gho, D Stollenwer, GJ Gores, NF LaRusso
J. Biol. Chem., 2019-10-28;0(0):.  2019-10-28

Pseudolaric Acid B Induces Growth Inhibition and Caspase-Dependent Apoptosis on Head and Neck Cancer Cell lines through Death Receptor 5
Authors: SJ Choi, CH Ahn, IH Yang, B Jin, WW Lee, JH Kim, MH Ahn, N Swarup, KO Hong, JA Shin, NT Woo, SD Hong, JI Lee, SD Cho
Molecules, 2019-10-16;24(20):.  2019-10-16

Platelet IP6K1 regulates neutrophil extracellular trap-microparticle complex formation in acute pancreatitis
Authors: R Madhi, M Rahman, D Taha, J Linders, M Merza, Y Wang, M Mörgelin, H Thorlacius
JCI Insight, 2019-10-07;0(0):.  2019-10-07

Evidence of necroptosis in osteoarthritic disease: investigation of blunt mechanical impact as possible trigger in regulated necrosis
Authors: J Riegger, RE Brenner
Cell Death Dis, 2019-09-17;10(10):683.  2019-09-17

Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77
Authors: PR Mittelstad, MD Taves, JD Ashwell
J. Immunol., 2019-09-16;0(0):.  2019-09-16

Solid state fermentation process with Aspergillus kawachii enhances the cancer-suppressive potential of silkworm larva in hepatocellular carcinoma cells
Authors: HD Cho, HJ Min, YS Won, HY Ahn, YS Cho, KI Seo
BMC Complement Altern Med, 2019-09-05;19(1):241.  2019-09-05

Axl Inhibitor R428 Enhances TRAIL-Mediated Apoptosis Through Downregulation of c-FLIP and Survivin Expression in Renal Carcinoma
Authors: SM Woo, KJ Min, SU Seo, S Kim, P Kubatka, JW Park, TK Kwon
Int J Mol Sci, 2019-07-02;20(13):.  2019-07-02

N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation
Authors: D Yamasoba, K Sato, T Ichinose, T Imamura, L Koepke, S Joas, E Reith, D Hotter, N Misawa, K Akaki, T Uehata, T Mino, S Miyamoto, T Noda, A Yamashita, DM Standley, F Kirchhoff, D Sauter, Y Koyanagi, O Takeuchi
Nat Microbiol, 2019-05-27;0(0):.  2019-05-27

Caspase-1 initiates apoptosis in the absence of gasdermin D
Authors: K Tsuchiya, S Nakajima, S Hosojima, D Thi Nguyen, T Hattori, T Manh Le, O Hori, MR Mahib, Y Yamaguchi, M Miura, T Kinoshita, H Kushiyama, M Sakurai, T Shiroishi, T Suda
Nat Commun, 2019-05-07;10(1):2091.  2019-05-07

Therapeutic efficacy of a novel ?III/?IV-tubulin inhibitor (VERU-111) in pancreatic cancer
Authors: VK Kashyap, Q Wang, S Setua, PKB Nagesh, N Chauhan, S Kumari, P Chowdhury, DD Miller, MM Yallapu, W Li, M Jaggi, BB Hafeez, SC Chauhan
J. Exp. Clin. Cancer Res., 2019-01-23;38(1):29.  2019-01-23

Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease
Authors: WK Saeed, DW Jun, K Jang, SB Ahn, JH Oh, YJ Chae, JS Lee, HT Kang
World J. Gastroenterol., 2018-12-28;24(48):5477-5490.  2018-12-28

Induction of immunosuppressive functions and NF-?B by FLIP in monocytes
Authors: A Fiore, S Ugel, F De Sanctis, S Sandri, G Fracasso, R Trovato, S Sartoris, S Solito, S Mandruzzat, F Vascotto, KL Hippen, G Mondanelli, U Grohmann, G Piro, C Carbone, D Melisi, RT Lawlor, A Scarpa, A Lamolinara, M Iezzi, M Fassan, S Bicciato, BR Blazar, U Sahin, PJ Murray, V Bronte
Nat Commun, 2018-12-05;9(1):5193.  2018-12-05

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human
Authors: BN Singh, N Koyano-Nak, W Gong, IP Moskowitz, CV Weaver, E Braunlin, S Das, JH van Berlo, MG Garry, DJ Garry
Nat Commun, 2018-10-12;9(1):4237.  2018-10-12

Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury
Authors: Z Zhang, X Shao, N Jiang, S Mou, L Gu, S Li, Q Lin, Y He, M Zhang, W Zhou, Z Ni
Cell Death Dis, 2018-09-24;9(10):983.  2018-09-24

BAP1 links metabolic regulation of ferroptosis to tumour suppression
Authors: Y Zhang, J Shi, X Liu, L Feng, Z Gong, P Koppula, K Sirohi, X Li, Y Wei, H Lee, L Zhuang, G Chen, ZD Xiao, MC Hung, J Chen, P Huang, W Li, B Gan
Nat. Cell Biol., 2018-09-10;0(0):.  2018-09-10

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death
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Cell Death Dis, 2018-09-05;9(9):904.  2018-09-05

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells
Authors: JM Yun, SM Woo, SU Seo, KJ Min, DE Kim, TK Kwon
Molecules, 2018-09-05;23(9):.  2018-09-05

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells
Authors: TW Kim, SY Lee, M Kim, C Cheon, SG Ko
Cell Death Dis, 2018-08-29;9(9):875.  2018-08-29

Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress
Authors: SU Seo, KJ Min, SM Woo, TK Kwon
Exp. Mol. Med., 2018-08-17;50(8):107.  2018-08-17

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy
Authors: SU Seo, SM Woo, HS Lee, SH Kim, KJ Min, TK Kwon
Oncogene, 2018-05-30;0(0):.  2018-05-30

Pseudopodium-enriched atypical kinase 1 mediates angiogenesis by modulating GATA2-dependent VEGFR2 transcription
Authors: H Wang, J Lapek, K Fujimura, J Strnadel, B Liu, DJ Gonzalez, W Zhang, F Watson, V Yu, C Liu, CM Melo, YI Miller, KC Elliott, DA Cheresh, RL Klemke
Cell Discov, 2018-05-29;4(0):26.  2018-05-29

Integrin ?6?4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues
Authors: SH Jung, M Lee, HA Park, HC Lee, D Kang, HJ Hwang, C Park, DM Yu, YR Jung, MN Hong, YN Kim, HJ Park, YG Ko, JS Lee
Cell Death Differ., 2018-05-21;0(0):.  2018-05-21

P53 and mTOR signalling determine fitness selection through cell competition during early mouse embryonic development
Authors: S Bowling, A Di Gregori, M Sancho, S Pozzi, M Aarts, M Signore, M D Schneide, JPM Barbera, J Gil, TA Rodríguez
Nat Commun, 2018-05-02;9(1):1763.  2018-05-02

BCI induces apoptosis via generation of reactive oxygen species and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells
Authors: JW Shin, SB Kwon, Y Bak, SK Lee, DY Yoon
Sci China Life Sci, 2018-03-28;0(0):.  2018-03-28

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice
Authors: Y Wang, L Luo, OÖ Braun, J Westman, R Madhi, H Herwald, M Mörgelin, H Thorlacius
Sci Rep, 2018-03-05;8(1):4020.  2018-03-05

Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes
Authors: AJ Lakhter, RE Pratt, RE Moore, KK Doucette, BF Maier, LA DiMeglio, EK Sims
Diabetologia, 2018-02-14;0(0):.  2018-02-14

7-Oxygenated cholesterol molecules differentially affect the expression of zonula occludens-1 in vascular smooth muscle cells and monocyte/macrophage cells
Authors: HR Cho, K Kim, WG An, SK Eo, SS Bae, CD Kim, Y Son
Biochem. Biophys. Res. Commun., 2018-02-08;0(0):.  2018-02-08

Herbal formula YGJDSJ inhibits anchorage-independent growth and induces anoikis in hepatocellular carcinoma Bel-7402 cells
Authors: B Hu, T Zhang, HM An, JL Zheng, X Yan, XW Huang
BMC Complement Altern Med, 2018-01-16;18(1):17.  2018-01-16

Ophiobolin A kills human glioblastoma cells by inducing endoplasmic reticulum stress via disruption of thiol proteostasis
Authors: IY Kim, M Kwon, MK Choi, D Lee, DM Lee, MJ Seo, KS Choi
Oncotarget, 2017-11-20;8(63):106740-106752.  2017-11-20

Elevated humoral response to cytomegalovirus in HIV-infected individuals with poor CD4+ T-cell immune recovery
Authors: E Gómez-Mora, M Massanella, E García, D Giles, M Bernadó, V Urrea, J Carrillo, D Ouchi, J Puig, E Negredo, B Clotet, J Blanco, C Cabrera
PLoS ONE, 2017-09-21;12(9):e0184433.  2017-09-21

MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation
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EMBO Mol Med, 2017-09-01;0(0):.  2017-09-01

Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
Authors: Y Shlyakhtin, V Pavet, H Gronemeyer
Cell Death Dis, 2017-08-31;8(8):e3025.  2017-08-31

Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma
Authors: RM Stammer, S Kleinsimon, J Rolff, S Jäger, A Eggert, G Seifert, CI Delebinski
J Immunol Res, 2017-07-16;2017(0):4874280.  2017-07-16

Distinct Mechanisms Underlying Resveratrol-Mediated Protection from Types of Cellular Stress in C6 Glioma Cells
Authors: JC Means, BC Gerdes, P Koulen
Int J Mol Sci, 2017-07-14;18(7):.  2017-07-14

PP2A inhibition from LB100 therapy enhances daunorubicin cytotoxicity in secondary acute myeloid leukemia via miR-181b-1 upregulation
Authors: C Hu, M Yu, Y Ren, K Li, DM Maggio, C Mei, L Ye, J Wei, J Jin, Z Zhuang, H Tong
Sci Rep, 2017-06-06;7(1):2894.  2017-06-06

Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins
Authors: XH Wang, SF Zhang, JT Bao, FY Liu
Tumour Biol., 2017-06-01;39(6):1010428317701.  2017-06-01

Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Authors: HJ Kim, KE Hwang, DS Park, SH Oh, HY Jun, KH Yoon, ET Jeong, HR Kim, YS Kim
J Transl Med, 2017-05-31;15(1):123.  2017-05-31

Lentinan from shiitake selectively attenuates AIM2 and non-canonical inflammasome activation while inducing pro-inflammatory cytokine production
Authors: H Ahn, E Jeon, JC Kim, SG Kang, SI Yoon, HJ Ko, PH Kim, GS Lee
Sci Rep, 2017-05-02;7(1):1314.  2017-05-02

Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1-localization
Authors: K Kobbenes S, TV Kalvik, G Bjørkøy, T Arnesen
Biosci. Rep., 2017-04-28;0(0):.  2017-04-28

Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis
Authors: MJ Mitchell, J Webster, A Chung, PP Guimarães, OF Khan, R Langer
Nat Commun, 2017-03-20;8(0):14179.  2017-03-20

Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-? through up-regulation of TNF receptor 1 in lung cancer cells.
Authors: Bo Ra You, Bo Ram Han, Woo Hyun Park
Oncotarget, 2017-03-14;0(0):1949-2553.  2017-03-14

The cyanobacterial metabolite nocuolin a is a natural oxadiazine that triggers apoptosis in human cancer cells
Authors: K Vorá?ová, J Hájek, J Mareš, P Urajová, M Kuzma, J Cheel, A Villunger, A Kapuscik, M Bally, P Novák, M Kabelá?, G Krumschnab, M Lukeš, L Voloshko, J Kopecký, P Hrouzek
PLoS ONE, 2017-03-02;12(3):e0172850.  2017-03-02

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress
PLoS ONE, 2016-12-19;11(12):e0168641.  2016-12-19

Hepatitis C Virus Infection of Cultured Human Hepatoma Cells Causes Apoptosis and Pyroptosis in Both Infected and Bystander Cells
Sci Rep, 2016-12-15;6(0):37433.  2016-12-15

Targeted inhibition of Polo-like kinase 1 by a novel small-molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells
J. Cell. Mol. Med, 2016-11-23;0(0):.  2016-11-23

A Subpopulation of the K562 Cells Are Killed by Curcumin Treatment after G2/M Arrest and Mitotic Catastrophe
PLoS ONE, 2016-11-10;11(11):e0165971.  2016-11-10

The multi-target drug BAI induces apoptosis in various human cancer cells through modulation of Bcl-xL protein
Authors: Jong-Wook Park
Int. J. Oncol., 2016-11-03;49(6):2620-2628.  2016-11-03

Knockdown of RIPK1 Markedly Exacerbates Murine Immune-Mediated Liver Injury through Massive Apoptosis of Hepatocytes, Independent of Necroptosis and Inhibition of NF-?B
J Immunol, 2016-09-07;0(0):.  2016-09-07

New derivatives of the antimalarial drug Pyrimethamine in the control of melanoma tumor growth: an in vitro and in vivo study
J Exp Clin Cancer Res, 2016-09-06;35(1):137.  2016-09-06

Multiple Active Compounds from Viscum album L. Synergistically Converge to Promote Apoptosis in Ewing Sarcoma
PLoS ONE, 2016-09-02;11(9):e0159749.  2016-09-02

IL-1? is an innate immune sensor of microbial proteolysis
Authors: CN LaRock, J Todd, DL LaRock, J Olson, AJ O'Donoghue, AA Robertson, MA Cooper, HM Hoffman, V Nizet
Sci Immunol, 2016-08-19;1(2):.  2016-08-19

Inhibiting Mitochondrial DNA Ligase III? Activates Caspase 1-Dependent Apoptosis in Cancer Cells
Authors: A Sallmyr, Y Matsumoto, V Roginskaya, B Van Houten, AE Tomkinson
Cancer Res., 2016-08-08;76(18):5431-41.  2016-08-08

Induction of apoptosis by Armillaria mellea constituent armillarikin in human hepatocellular carcinoma
Onco Targets Ther, 2016-08-01;9(0):4773-83.  2016-08-01

Lapatinib induces autophagic cell death and differentiation in acute myeloblastic leukemia
Onco Targets Ther, 2016-07-20;9(0):4453-64.  2016-07-20

Anti-apoptotic Effects of Human Wharton's Jelly-derived Mesenchymal Stem Cells on Skeletal Muscle Cells Mediated via Secretion of XCL1
Mol Ther, 2016-06-23;0(0):.  2016-06-23

A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Authors: Jing Fang
Nat Med, 2016-06-13;0(0):.  2016-06-13

Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells
Authors: Marie-Claude Gaudreau
Sci Rep, 2016-06-07;6(0):27379.  2016-06-07

Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016-05-24;0(0):.  2016-05-24

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL.
Authors: French R, Hayward O, Jones S, Yang W, Clarkson R
Mol Cancer, 2015-12-15;14(0):209.  2015-12-15

Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
Authors: Hernandez-Corbacho M, Canals D, Adada M, Liu M, Senkal C, Yi J, Mao C, Luberto C, Hannun Y, Obeid L
J Biol Chem, 2015-08-28;290(42):25356-73.  2015-08-28

Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015-08-24;10(8):e0136708.  2015-08-24

Cold Atmospheric Plasma Induces a Predominantly Necrotic Cell Death via the Microenvironment.
Authors: Virard F, Cousty S, Cambus J, Valentin A, Kemoun P, Clement F
PLoS ONE, 2015-08-14;10(8):e0133120.  2015-08-14

Calpain Determines the Propensity of Adult Hippocampal Neural Stem Cells to Autophagic Cell Death Following Insulin Withdrawal.
Authors: Chung K, Park H, Jung S, Ha S, Yoo S, Woo H, Lee H, Kim S, Kim E, Moon C, Yu S
Stem Cells, 2015-07-14;33(10):3052-64.  2015-07-14

Wee-1 Kinase Inhibition Sensitizes High-Risk HPV+ HNSCC to Apoptosis Accompanied by Downregulation of MCl-1 and XIAP Antiapoptotic Proteins.
Authors: Tanaka N, Patel A, Wang J, Frederick M, Kalu N, Zhao M, Fitzgerald A, Xie T, Silver N, Caulin C, Zhou G, Skinner H, Johnson F, Myers J, Osman A
Clin Cancer Res, 2015-06-29;21(21):4831-44.  2015-06-29

Metformin Causes G1-Phase Arrest via Down-Regulation of MiR-221 and Enhances TRAIL Sensitivity through DR5 Up-Regulation in Pancreatic Cancer Cells.
Authors: Tanaka R, Tomosugi M, Horinaka M, Sowa Y, Sakai T
PLoS ONE, 2015-05-08;10(5):e0125779.  2015-05-08

Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
Stem Cells, 2015-05-01;33(5):1670-81.  2015-05-01

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.
Authors: Martelli M, Gionfriddo I, Mezzasoma F, Milano F, Pierangeli S, Mulas F, Pacini R, Tabarrini A, Pettirossi V, Rossi R, Vetro C, Brunetti L, Sportoletti P, Tiacci E, Di Raimondo F, Falini B
Blood, 2015-03-20;125(22):3455-65.  2015-03-20

Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis.
Authors: Braun F, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F
PLoS ONE, 2015-03-04;10(3):e0117994.  2015-03-04

Non-thermal plasma with 2-deoxy-D-glucose synergistically induces cell death by targeting glycolysis in blood cancer cells.
Authors: Kaushik, Neha, Lee, Su Jae, Choi, Tae Gyu, Baik, Ku Youn, Uhm, Han Sup, Kim, Chung Hy, Kaushik, Nagendra, Choi, Eun Ha
Sci Rep, 2015-03-04;5(0):8726.  2015-03-04

A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response.
Authors: Sanyal A, Chen A, Nakayasu E, Lazar C, Zbornik E, Worby C, Koller A, Mattoo S
J Biol Chem, 2015-01-19;290(13):8482-99.  2015-01-19

Nlrx1 regulates neuronal cell death.
Authors: Imbeault E, Mahvelati T, Braun R, Gris P, Gris D
Mol Brain, 2014-12-24;7(0):90.  2014-12-24

IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth.
Authors: Sanz R, Ferraro G, Fournier A
J Biol Chem, 2014-12-23;290(7):4330-42.  2014-12-23

Modulation of specificity protein 1 by mithramycin A as a novel therapeutic strategy for cervical cancer.
Authors: Choi, Eun-Sun, Nam, Jeong-Se, Jung, Ji-Youn, Cho, Nam-Pyo, Cho, Sung-Dae
Sci Rep, 2014-11-24;4(0):7162.  2014-11-24

Rose Bengal acetate photodynamic therapy (RBAc-PDT) induces exposure and release of Damage-Associated Molecular Patterns (DAMPs) in human HeLa cells.
Authors: Panzarini, Elisa, Inguscio, Valentin, Fimia, Gian Mar, Dini, Luciana
PLoS ONE, 2014-08-20;9(8):e105778.  2014-08-20

Myeloid zinc finger 1 mediates sulindac sulfide-induced upregulation of death receptor 5 of human colon cancer cells.
Authors: Horinaka, Mano, Yoshida, Tatsushi, Tomosugi, Mitsuhir, Yasuda, Shusuke, Sowa, Yoshihir, Sakai, Toshiyuk
Sci Rep, 2014-08-08;4(0):6000.  2014-08-08

Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.
Authors: Teigler J, Kagan J, Barouch D
J Virol, 2014-07-02;88(18):10354-63.  2014-07-02

The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis.
Authors: Mueller-Ortiz S, Morales J, Wetsel R
J Immunol, 2014-06-30;193(3):1278-89.  2014-06-30

TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications.
Authors: Jang, Jae Youn, Kim, Seong-Ju, Cho, Eun Kyun, Jeong, Soung Wo, Park, Eui Ju, Lee, Woong Ch, Lee, Sae Hwan, Kim, Sang Gyu, Kim, Young Se, Kim, Hong Soo, Kim, Boo Sung, Lin, Wenyu, Chung, Raymond
PLoS ONE, 2014-06-13;9(6):e98171.  2014-06-13

Apoptosis and pro-inflammatory cytokine response of mast cells induced by influenza A viruses.
Authors: Liu B, Meng D, Wei T, Zhang S, Hu Y, Wang M
PLoS ONE, 2014-06-12;9(6):e100109.  2014-06-12

5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-delta
Authors: Mhaidat N, Bouklihacene M, Thorne R
Oncol Lett, 2014-06-02;8(2):699-704.  2014-06-02

The PPARgamma agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells.
Authors: Yan S, Yang X, Chen T, Xi Z, Jiang X
Cancer Gene Ther, 2014-05-23;21(5):188-93.  2014-05-23

Soluble CEACAM8 interacts with CEACAM1 inhibiting TLR2-triggered immune responses.
Authors: Singer B, Opp L, Heinrich A, Schreiber F, Binding-Liermann R, Berrocal-Almanza L, Heyl K, Muller M, Weimann A, Zweigner J, Slevogt H
PLoS ONE, 2014-04-17;9(4):e94106.  2014-04-17

Interleukin 17A promotes pneumococcal clearance by recruiting neutrophils and inducing apoptosis through a p38 mitogen-activated protein kinase-dependent mechanism in acute otitis media.
Authors: Wang, Wei, Zhou, Aie, Zhang, Xuemei, Xiang, Yun, Huang, Yifei, Wang, Lei, Zhang, Shuai, Liu, Yusi, Yin, Yibing, He, Yujuan
Infect Immun, 2014-03-24;82(6):2368-77.  2014-03-24

Anti-apoptotic effect of caspase inhibitors on H(2)O(2)-treated HeLa cells through early suppression of its oxidative stress.
Authors: Park W
Oncol Rep, 2014-03-12;31(5):2413-21.  2014-03-12

Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014-03-12;44(5):1745-55.  2014-03-12

Inhibition of ANKRD1 sensitizes human ovarian cancer cells to endoplasmic reticulum stress-induced apoptosis.
Authors: Lei, Y, Henderson, B R, Emmanuel, C, Harnett, P R, deFazio, A
Oncogene, 2014-02-17;34(4):485-95.  2014-02-17

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses.
Authors: Bulau A, Nold M, Li S, Nold-Petry C, Fink M, Mansell A, Schwerd T, Hong J, Rubartelli A, Dinarello C, Bufler P
Proc Natl Acad Sci U S A, 2014-01-30;111(7):2650-5.  2014-01-30

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.
Authors: Shi Y, Nikulenkov F, Zawacka-Pankau J, Li H, Gabdoulline R, Xu J, Eriksson S, Hedstrom E, Issaeva N, Kel A, Arner E, Selivanova G
Cell Death Differ, 2014-01-10;21(4):612-23.  2014-01-10

Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis.
Authors: Bielaszewska M, Ruter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim K, Mellmann A, Schmidt M, Karch H
PLoS Pathog, 2013-12-12;9(12):e1003797.  2013-12-12

Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma.
Authors: Wang, Jian-Gan, Zheng, Xing-Xin, Zeng, Guang-Ya, Zhou, Ying-Jun, Yuan, Hong
Oncol Rep, 2013-11-15;31(1):488-96.  2013-11-15

Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
Authors: McCloy R, Shelley E, Roberts C, Boslem E, Biden T, Nicholson R, Gee J, Sutherland R, Musgrove E, Burgess A, Butt A
Br J Cancer, 2013-10-31;109(12):3034-41.  2013-10-31

PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
Authors: You B, Shin H, Park W
Int J Oncol, 2013-10-29;44(1):301-8.  2013-10-29

Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
Cancer Cell Int, 2013-10-23;13(1):105.  2013-10-23

PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin H, You B, Park W
Oncol Lett, 2013-10-21;6(6):1804-1810.  2013-10-21

Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
Elife, 2013-10-15;2(0):e00999.  2013-10-15

Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
Authors: Han B, You B, Park W
Oncol Rep, 2013-09-20;30(6):2999-3005.  2013-09-20

Hexokinase 1 blocks apoptotic signals at the mitochondria.
Authors: Schindler A, Foley E
Cell Signal, 2013-09-07;25(12):2685-92.  2013-09-07

NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration.
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FASEB J, 2013-08-23;27(12):4712-22.  2013-08-23

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance.
Authors: Zhang, Xiangnan, Yan, Haijing, Yuan, Yang, Gao, Jieqiong, Shen, Zhe, Cheng, Yun, Shen, Yao, Wang, Rong-Ron, Wang, Xiaofen, Hu, Wei-Wei, Wang, Guanghui, Chen, Zhong
Autophagy, 2013-06-12;9(9):1321-33.  2013-06-12

Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
Authors: D'Agnillo, Felice, Williams, Matthew, Moayeri, Mahtab, Warfel, Jason M
PLoS ONE, 2013-04-23;8(4):e62576.  2013-04-23

Activation of the innate signaling molecule MAVS by bunyavirus infection upregulates the adaptor protein SARM1, leading to neuronal death.
Authors: Mukherjee P, Woods T, Moore R, Peterson K
Immunity, 2013-03-14;38(4):705-16.  2013-03-14

Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke.
Authors: Li C, Liu Y, Chen Y, Yu D, Williams K, Liu M
Am J Pathol, 2013-03-13;182(5):1552-62.  2013-03-13

Ex vivo modeling of chemical synergy in prenatal kidney cystogenesis.
Authors: Anders, Corina, Ashton, Nick, Ranjzad, Parisa, Dilworth, Mark R, Woolf, Adrian S
PLoS ONE, 2013-03-12;8(3):e57797.  2013-03-12

Regulation of hepatitis C virus replication by nuclear translocation of nonstructural 5A protein and transcriptional activation of host genes.
Authors: Maqbool M, Imache M, Higgs M, Carmouse S, Pawlotsky J, Lerat H
J Virol, 2013-03-06;87(10):5523-39.  2013-03-06

Bombesin analogue-mediated delivery preferentially enhances the cytotoxicity of a mitochondria-disrupting peptide in tumor cells.
Authors: Yang H, Cai H, Wan L, Liu S, Li S, Cheng J, Lu X
PLoS ONE, 2013-02-25;8(2):e57358.  2013-02-25

The interplays between autophagy and apoptosis induced by enterovirus 71.
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PLoS ONE, 2013-02-20;8(2):e56966.  2013-02-20

Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
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Int J Oncol, 2012-12-12;42(2):525-34.  2012-12-12

TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
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Mol Cell Biol, 2012-11-19;33(3):582-95.  2012-11-19

dsRNA induces apoptosis through an atypical death complex associating TLR3 to caspase-8.
Cell Death Differ., 2012-03-16;19(9):1482-94.  2012-03-16

TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8.
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J. Biol. Chem., 2011-04-27;286(24):21546-54.  2011-04-27

Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010-03-25;115(24):5041-52.  2010-03-25

Sensitization of imatinib-resistant CML cells to TRAIL-induced apoptosis is mediated through down-regulation of Bcr-Abl as well as c-FLIP.
Authors: Park SJ, Kim MJ, Kim HB, Kang CD, Kim SH
Biochem. J., 2009-04-28;420(1):73-81.  2009-04-28

Effects of erythropoietin in skin wound healing are dose related.
Authors: Sorg H, Krueger C, Schulz T, Menger MD, Schmitz F, Vollmar B
FASEB J., 2009-04-27;23(9):3049-58.  2009-04-27

AMP-activated protein kinase-dependent and -independent mechanisms underlying in vitro antiglioma action of compound C.
Authors: Vucicevic L, Misirkic M, Janjetovic K, Harhaji-Trajkovic L, Prica M, Stevanovic D, Isenovic E, Sudar E, Sumarac-Dumanovic M, Micic D, Trajkovic V
Biochem. Pharmacol., 2009-03-14;77(11):1684-93.  2009-03-14

Trichostatin A sensitizes human ovarian cancer cells to TRAIL-induced apoptosis by down-regulation of c-FLIPL via inhibition of EGFR pathway.
Authors: Park SJ, Kim MJ, Kim HB, Sohn HY, Bae JH, Kang CD, Kim SH
Biochem. Pharmacol., 2009-01-24;77(8):1328-36.  2009-01-24

Active caspase-1-mediated secretion of retinoic acid inducible gene-I.
Authors: Kim, Min-Jung, Yoo, Joo-Yeon
J Immunol, 2008-11-15;181(10):7324-31.  2008-11-15

Caspase inhibitor infusion protects an avian song control circuit from seasonal-like neurodegeneration.
Authors: Thompson CK, Brenowitz EA
J. Neurosci., 2008-07-09;28(28):7130-6.  2008-07-09

Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons.
Authors: Ladewig J, Koch P, Endl E, Meiners B, Opitz T, Couillard-Despres S, Aigner L, Brustle O
Stem Cells, 2008-04-17;26(7):1705-12.  2008-04-17

Theiler's virus-induced intrinsic apoptosis in M1-D macrophages is Bax mediated and restricts virus infectivity: a mechanism for persistence of a cytolytic virus.
Authors: Son KN, Becker RP, Kallio P, Lipton HL
J. Virol., 2008-02-20;82(9):4502-10.  2008-02-20

The microtubule-targeting agent CA4P regresses leukemic xenografts by disrupting interaction with vascular cells and mitochondrial-dependent cell death.
Authors: Petit I, Karajannis MA, Vincent L, Young L, Butler J, Hooper AT, Shido K, Steller H, Chaplin DJ, Feldman E, Rafii S
Blood, 2007-11-16;111(4):1951-61.  2007-11-16

Regulation of the extrinsic apoptotic pathway by the extracellular matrix glycoprotein EMILIN2.
Authors: Mongiat M, Ligresti G, Marastoni S, Lorenzon E, Doliana R, Colombatti A
Mol. Cell. Biol., 2007-08-13;27(20):7176-87.  2007-08-13

Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells.
Authors: Plachta N, Annaheim C, Bissiere S, Lin S, Ruegg M, Hoving S, Muller D, Poirier F, Bibel M, Barde YA
Nat. Neurosci., 2007-05-07;10(6):712-9.  2007-05-07

Bakuchiol-induced caspase-3-dependent apoptosis occurs through c-Jun NH2-terminal kinase-mediated mitochondrial translocation of Bax in rat liver myofibroblasts.
Authors: Park EJ, Zhao YZ, Kim YC, Sohn DH
Eur. J. Pharmacol., 2007-01-23;559(2):115-23.  2007-01-23

Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
Mol. Cancer Ther., 2006-12-01;5(12):2977-90.  2006-12-01

Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction.
Authors: Karrar A, Broome U, Uzunel M, Qureshi AR, Sumitran-Holgersson S
Gut, 2006-07-13;56(2):243-52.  2006-07-13

Embryonic stem cell-derived neuron models of Parkinson's disease exhibit delayed neuronal death.
Authors: Yamashita H, Nakamura T, Takahashi T, Nagano Y, Hiji M, Hirabayashi T, Amano T, Yagi T, Sakai N, Kohriyama T, Matsumoto M
J. Neurochem., 2006-07-01;98(1):45-56.  2006-07-01

Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006-06-13;281(32):22503-16.  2006-06-13

TLR3 can directly trigger apoptosis in human cancer cells.
Authors: Salaun B, Coste I, Rissoan MC, Lebecque SJ, Renno T
J. Immunol., 2006-04-15;176(8):4894-901.  2006-04-15

Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Authors: Lee SC, Chan J, Clement MV, Pervaiz S
Proteomics, 2006-04-01;6(8):2386-94.  2006-04-01

Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
Cancer Lett., 2004-11-19;222(2):183-93.  2004-11-19

Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004-11-01;34(11):3236-45.  2004-11-01

RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004-02-24;103(11):4180-7.  2004-02-24

Apaf-1 is a mediator of E2F-1-induced apoptosis.
Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
J. Biol. Chem., 2002-07-30;277(42):39760-8.  2002-07-30

Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Authors: Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ
Eur. J. Immunol., 2002-05-01;32(5):1464-71.  2002-05-01