Pam2CSK4
Purity: ≥95%
Biological Activity
Pam2CSK4 is a toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.Technical Data
(Modifications: Cys-1 = S-[2,3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells.
Boeglin et al.
PLoS One, 2011;6:e25542 -
Domain exchange between human Toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination.
Omueti et al.
J.Biol.Chem., 2005;280:36616 -
Physiochemical and biological analysis of synthetic bacterial lipopeptides: validity of the concept of endotoxic conformation.
Schromm et al.
J.Biol.Chem., 2007;282:11030
Product Datasheets
Citations for Pam2CSK4
The citations listed below are publications that use Tocris products. Selected citations for Pam2CSK4 include:
3 Citations: Showing 1 - 3
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Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cells.
Authors: Alexa Et al.
Heliyon 2023;9:e15202
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Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence.
Authors: Valerie G Et al.
Cell Death Differ 2022;29:1267-1282
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The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype.
Authors: Hari Et al.
Sci Adv 2019;5:eaaw0254
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