PACAP 1-38
Purity: ≥95%
Biological Activity
PACAP 1-38 is a potent endogenous neuropeptide (IC50 = 2 nM) showing considerable homology with vasoactive intestinal peptide (VIP) but with a greater potency for stimulation of adenylyl cyclase. PACAP 1-38 induces phosphorylation of NR2B and enhances NMDA receptor potentials.Technical Data
(Modifications: Lys-38 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist.
Robberecht et al.
Eur.J.Biochem., 1992;207:239 -
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
Michel et al.
Pharmacol.Rev., 1998;50:143 -
The 38-amino-acid form of pituitary adenylate cyclase-activating polypeptide induces neurite outgrowth in PC12 cells that is dependent on protein kinase C and extracellular signal-regulated kinase but not on protein kinase A, nerve growth factor receptor
Lazarovici et al.
Mol.Pharmacol., 1998;54:547 -
Pituitary adenylate cyclase-activating polypeptide increase [Ca2+]i in rat gonadotrophs through an inositol trisphosphate-dependent mechanism.
Rawlings et al.
J.Biol.Chem., 1994;269:5680
Product Datasheets
Citations for PACAP 1-38
The citations listed below are publications that use Tocris products. Selected citations for PACAP 1-38 include:
3 Citations: Showing 1 - 3
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PACAP ameliorates hepatic metabolism and inflammation through up-regulating FAIM in obesity.
Authors: Xiao Et al.
J Cell Mol Med 2019;
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Pituitary adenylate cyclase-activating polypeptide protects glomerular podocytes from inflammatory injuries.
Authors: Sakamoto Et al.
J Diabetes Res 2015;2015:727152
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Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
Authors: Nostramo Et al.
J Cereb Blood Flow Metab 2012;215:291
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