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Ortho AP 1867

Catalog #: 7787 Datasheet
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7787/10
7787/50
Ortho AP 1867 | CAS No. 2230613-03-1 | FKBP12
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Description: Selective binding ligand for FKBP12F36V; precursor for dTAG compounds

Chemical Name: 2-(2-((R)-3-(3,4-Dimethoxyphenyl)-1-(((S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carbonyl)oxy)propyl)phenoxy)acetic acid

Purity: ≥98%

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ortho AP 1867 is a selective binding ligand for the single point mutant of FKBP12F36V. Functionalized with a carboxylic acid group in the ortho-position to enable onward chemistry. The position of the carboxylic acid group represents an 'exit vector' allowing modification without interfering with compound binding ability. Ortho AP 1867 is a precursor for the dTAG compounds.

Technical Data

M.Wt:
693.79
Formula:
C38H47NO11
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2230613-03-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The dTAG system for immediate and target-specific protein degradation.
    Nabet et al.
    Nat.Chem.Biol., 2018;14:431

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