OPC 21268

Catalog #: 3924
3 Citations Datasheet

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OPC 21268 | CAS No. 131631-89-5 | Vasopressin Receptor Agonists

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Description: Orally active vasopressin V1 antagonist

Chemical Name: N-[3-[4-[[4-(3,4-Dihydro-2-oxo-1(2H)quinolinyl)-1-piperidinyl]carbonyl]phenoxy]propyl]-acetamide

Purity: ≥98%

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Product Details

Citations (3)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

OPC 21268 is a nonpeptide vasopressin V₁ receptor antagonist. Displays greater affinity for rat V₁ than human V₁ (K_i values are 25 and 8800 nM respectively). Exhibits 1000-fold selectivity for V₁ receptors over V₂ receptors. Orally active.

Technical Data

M.Wt:

449.54

Formula:

C₂₆H₃₁N₃O₄

Solubility:

Soluble to 100 mM in DMSO and to 25 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

131631-89-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist.
Yamamura et al.
Science, 1991;252:572
Effects of OPC-21268, an orally effective vasopressin V₁ receptor antagonist in humans.
Imaizumi et al.
Hypertension, 1992;20:54
A molecular model of agonist and nonpeptide antagonist binding to the human V₁ vascular vasopressin receptor.
Thibonnier et al.
J.Pharmacol.Exp.Ther., 2000;294:195

Product Datasheets

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SDS

Citations for OPC 21268

The citations listed below are publications that use Tocris products. Selected citations for OPC 21268 include:

3 Citations: Showing 1 - 3

Evidence for a Prehypertensive Water Dysregulation Affecting the Development of Hypertension: Results of Very Early Treatment of Vasopressin V1 and V2 Antagonism in Spontaneously Hypertensive Rats.
Authors: Gallia Et al.
Front Cardiovasc Med 2022;9:897244
Reduced VIP Expression Affects Circadian Clock Function in VIP-IRES-CRE Mice (JAX 010908).
Authors: Harshida Et al.
J Biol Rhythms 2020;35:340-352
Asymmetric vasopressin signaling spatially organizes the master circadian clock.
Authors: Amita Et al.
J Comp Neurol 2018;526:2048-2067

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