Ondansetron hydrochloride

Biological Activity

Ondansetron hydrochloride is a selective 5-HT₃ receptor antagonist (K_i = 6.16 nM). Also an inhibitor of human multidrug and toxin extrusion (MATE) transporter 1 (IC₅₀ = <10-160 nM). Ondansetron blocks 5-HT-evoked transient inward currents (IC₅₀ = 0.1 nM) in human recombinant h5-HT_3A receptors. In an animal model of Parkinson's disease, Ondansetron reduces both the severity of dyskinesia and psychosis-like behaviors. Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Development of high-affinity 5-HT₃ receptor antagonists. 1. Initial structure-activity relationship of novel benzamides.
   Youssefyeh et al.
   J.Med.Chem., 1992;35:895
2. Ondansetron: a selective 5-HT₃ receptor antagonist and its applications in CNS-related disorders.
   Ye et al.
   CNS Drug Rev., 2001;7:199
3. Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice.
   Ginawi et al.
   Pharmacol.Res., 2005;51:255

Product Datasheets