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Olanzapine

Catalog #: 4349
4 Citations Datasheet
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4349/50
Olanzapine | CAS No. 132539-06-1 | Non-selective 5-HT2 Receptor Antagonists
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Description: 5-HT2A antagonist; also D2 antagonist; atypical antipsychotic

Chemical Name: 2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine

Purity: ≥99%

Product Details
Citations (4)
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Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Olanzapine is an antagonist of 5-HT2A and dopamine D2 receptors (Ki values are 4 and 11 nM respectively). Also displays affinity for a range of other receptors including D1 and D4, 5-HT2C, α1, H1 and M1-4 receptors (Ki values range between 1.9 and 31 nM). Atypical antipsychotic. Displays anticholinergic properties. Also a highly potent activator of hM4Di DREADDs (EC50 values are 5 nM in vitro and 7 nM in vivo).

Technical Data

M.Wt:
312.43
Formula:
C17H20N4S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
132539-06-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

  1. Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
    Tollefson and Taylor
    CNS Drug Reviews, 2000;6:303
  2. The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.
    Moore et al.
    J.Pharmacol.Exp.Ther., 1992;262:545
  3. Radioreceptor binding profile of the atypical antipsychotic olanz.
    Bymaster et al.
    Neuropsychopharmacology, 1996;14:87

Product Datasheets

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Citations for Olanzapine

The citations listed below are publications that use Tocris products. Selected citations for Olanzapine include:

4 Citations: Showing 1 - 4

  1. Serotonin 2A (5-HT2A) receptor affects cell-matrix adhesion and the formation and maintenance of stress fibers in HEK293 cells.
    Authors: Mitradas M Et al.
    Sci Rep  2020;10:21675
  2. Identifying the In Vivo Cellular Correlates of Antipsychotic Drugs.
    Authors: Joshi and Panicker
    Eneuro  2019;5
  3. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia.
    Authors: Pérez-G?mez Et al.
    Nat Commun  2018;9:5272
  4. Lateral diffusion of Gαs in the plasma membrane is decreased after chronic but not acute antidepressant treatment: role of lipid raft and non-raft membrane microdomains.
    Authors: Czysz Et al.
    Nat Methods  2015;40:766

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