OICR 9429
Chemical Name: N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
Purity: ≥98%
Biological Activity
OICR 9429 is a high affinity WDR5 antagonist (Kd = 93 nM; IC50 = 64 nM); disrupts WDR5-MLL interaction. Exhibits selectivity for WDR5 over 22 methyltransferases and a panel of kinases, GPCRs, ion channels, and transporters. Reduces viability of acute myeloid leukemia cells in vitro. Also disrupts MLL1-RbBP5 interaction.To request the negative control for OICR 9429, please fill out the OICR 0547 request form on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of OICR 9429 is reviewed on the chemical probes website.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1).
Getlik et al.
J.Med.Chem., 2016;59:2478 -
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Grebien et al.
Nat.Chem.Biol., 2015;11:571
Product Datasheets
Citations for OICR 9429
The citations listed below are publications that use Tocris products. Selected citations for OICR 9429 include:
2 Citations: Showing 1 - 2
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Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation.
Authors: Ying Et al.
Nat Commun 2023;14:1694
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Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish.
Authors: Wolfgang Et al.
Front Genet 2020;11:80
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