OG-L002
Chemical Name: 4'-((1R,2S)-2-aminocyclopropyl)biphenyl-3-ol
Purity: ≥98%
Biological Activity
OG-L002 is a potent LSD1 inhibitor (IC50 = 20 nM). Exhibits some selectivity for LSD1 over MAO-B and MAO-A (IC50 values are 0.72 and 1.38 μM, respectively). Inhibits herpes simplex virus (HSV) immediate early gene expression and viral yield in vitro. Suppresses HSV primary infection in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.
Liang et al.
MBio., 2013;4:e00558
Product Datasheets
Citation for OG-L002
The citations listed below are publications that use Tocris products. Selected citations for OG-L002 include:
1 Citation: Showing 1 - 1
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Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
Authors: Chris Et al.
Elife 2020;9
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