NVP 231
Chemical Name: N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide
Purity: ≥98%
Biological Activity
NVP 231 is a potent, selective and reversible ceramide kinase (CerK) inhibitor (IC50 = 12 nM in vitro). Displays selectivity for CerK over sphingosine kinases (IC50 ≥100 μM) and other lipid kinases.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.
Graf et al.
Anal.Biochem., 2009;384:166 -
Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro.
Niwa et al.
Microvasc.Res., 2009;77:389
Product Datasheets
Citation for NVP 231
The citations listed below are publications that use Tocris products. Selected citations for NVP 231 include:
1 Citation: Showing 1 - 1
-
Cellular stress promotes NOD1/2-dependent inflammation via the endogenous metabolite sphingosine-1-phosphate.
Authors: Mikhail Et al.
EMBO J 2021;40:e106272
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for NVP 231
There are currently no reviews for this product. Be the first to review NVP 231 and earn rewards!
Have you used NVP 231?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
